About the Authors

Rexford D. Newbould

rexford.newbould@imanova.co.uk

Affiliation Imanova Centre for Imaging Sciences, Hammersmith Hospital, Imperial College London, London, United Kingdom

Sam R. Miller

Affiliation GlaxoSmithKline, Brentford, United Kingdom

Neil Upadhyay

Affiliation Department of Imaging, Charing Cross Hospital, Imperial College London, London, United Kingdom

Anil W. Rao

Affiliation GlaxoSmithKline, Brentford, United Kingdom

Peter Swann

Affiliation Department of Medicine, University of Oxford Medical School, Oxford, United Kingdom

Garry E. Gold

Affiliation Department of Radiology, Stanford University, Stanford, California, United States of America

Robin K. Strachan

Affiliation Department of Orthopaedic Surgery, Charing Cross Hospital, Imperial College London, London, United Kingdom

Paul M. Matthews

Affiliation Centre for Clinical Neurosciences, Department of Medicine, Imperial College, London, United Kingdom

Peter C. Taylor

Affiliation Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

Andrew P. Brown

Affiliation Imanova Centre for Imaging Sciences, Hammersmith Hospital, Imperial College London, London, United Kingdom

Competing Interests

The following authors were employees of GlaxoSmithKline and hold shares in the company; RDN, SRM, ARW, PMM and APB. The following authors were visiting research fellows at the GlaxoSmithKline Clinical Imaging Centre: PS. The following authors received research support from GlaxoSmithKline: PCT and RKS. GSK has a policy that all research study results, negative or positive, must be published. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: APB RDN PMM PCT GEG. Performed the experiments: APB RDN PCT RKS PS NU. Analyzed the data: RDN APB PS SRM NU AWR. Contributed reagents/materials/analysis tools: SRM AWR PMM. Wrote the manuscript: APB RDN SRM. Critical revision of the article for important intellectual content: PMM RKS GEG PCT. Provision of patients: RKS PCT. Statistical expertise: SRM. Obtaining of funding: APB PMM.