About the Authors

Steven M. Rowe

Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Bo Liu

Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Aubrey Hill

Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Heather Hathorne

Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Morty Cohen

Current address: Morty Cohen Research Consulting, Seattle, Washington, United States of America

Affiliation Seattle Children's Hospital, Seattle, Washington, United States of America

John R. Beamer

Current address: ALK Source Materials, Inc., Post Falls, Idaho, United States of America

Affiliation Seattle Children's Hospital, Seattle, Washington, United States of America

Frank J. Accurso

Affiliation University of Colorado Denver, Aurora, Colorado, United States of America

Qunming Dong

Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

Claudia L. Ordoñez

Current address: Biogen, Boston, Massachusetts, United States of America

Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

Anne J. Stone

Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

Eric R. Olson

Affiliation Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America

John P. Clancy

john.clancy@cchmc.org

Affiliation Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio, United States of America

for the VX06-770-101 Study Group

Membership of the VX06-770-101 Study Group is provided in the Acknowledgments.

Competing Interests

Several authors on this manuscript are (or were) employees of Vertex Pharmaceuticals (QD, CLO, AJS, and ERO), Drs. JPC, FJA, and SMR were site investigators for the primary study of interest that was funded by Vertex Pharmaceuticals, and Dr. JPC has served as a consultant for Vertex Pharmaceuticals (member of the CF Global Scientific Advisory Board). This does not alter the authors' adherence to all of the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SMR MC JB FJA CLO ERO JPC. Performed the experiments: SMR HH MC FJA JPC. Analyzed the data: SMR BL AH QD AJS JPC. Contributed reagents/materials/analysis tools: BL AH. Wrote the paper: SMR FJA QD JPC.