About the Authors

Ulrich Thiem

ulrich.thiem@rub.de

Affiliations Department of Geriatrics, University of Bochum, Marienhospital Herne, Herne, Germany, Department of Medical Informatics, Biometry and Epidemiology, University of Bochum, Bochum, Germany

Rainer Lamsfuß

Affiliation Department of Geriatrics, University of Bochum, Marienhospital Herne, Herne, Germany

Sven Günther

Affiliation Department of Geriatrics, University of Bochum, Marienhospital Herne, Herne, Germany

Jochen Schumacher

Affiliation Department of Internal Medicine, Alfried Krupp Krankenhaus Steele, University of Duisburg-Essen, Essen, Germany

Christian Bäker

Affiliation Department of Geriatrics, University of Bochum, Marienhospital Herne, Herne, Germany

Heinz G. Endres

Affiliation Department of Medical Informatics, Biometry and Epidemiology, University of Bochum, Bochum, Germany

Josef Zacher

Affiliation Department of Orthopedics, HELIOS Klinikum Berlin-Buch, Berlin, Germany

Gerd R. Burmester

Affiliation Department of Rheumatology and Clinical Immunology, Charite Berlin, University of Berlin, Berlin, Germany

Ludger Pientka

Affiliation Department of Geriatrics, University of Bochum, Marienhospital Herne, Herne, Germany

Competing Interests

The study was supported by an unrestricted research grant of MSD Sharp & Dohme, Haar, Germany. L. Pientka has received fees from MSD Sharp & Dohme, Haar, Germany, as a consultant and for lectures, and also funding for other research projects. J Zacher is employed by HELIOS Klinikum Berlin-Buch. There are no patents, products in development or marketed products to declare. This does not alter the authors′ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Interpreted the results: UT RL SG CB HGE LP. Revised the manuscript for important intellectual content: HGE RL SG JS CB JZ GRB LP. Conceived and designed the experiments: UT JS LP. Performed the experiments: UT RL SG JS. Analyzed the data: UT RL HGE. Wrote the paper: UT.