About the Authors

William Hinkle

Affiliations Department of Neuroscience, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America, fMRI Research Center, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America

Michael Cordell

Affiliations Institute of Human Nutrition, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America, fMRI Research Center, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America

Rudy Leibel

Affiliation Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America

Michael Rosenbaum

Affiliation Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America

Joy Hirsch

joy.hirsch@yale.edu

Affiliations Department of Neuroscience, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America, Departments of Radiology and Psychology, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America, fMRI Research Center, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, United States of America

Competing Interests

Recombinant methionyl human leptin was generously provided by Amylin Pharmaceuticals Inc. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RL MR JH. Performed the experiments: MR JH. Analyzed the data: WH MC MR JH. Contributed reagents/materials/analysis tools: WH MC. Wrote the paper: WH MC MR JH.