About the Authors
- Ellen Weisberg
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Contributed equally to this work with: Ellen Weisberg, Qingsong Liu
* E-mail: ellen_weisberg@dfci.harvard.edu (EW); james_griffin@dfci.harvard.edu (JDG)
Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Qingsong Liu
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Contributed equally to this work with: Ellen Weisberg, Qingsong Liu
Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
- Xin Zhang
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Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
- Erik Nelson
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Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Martin Sattler
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Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Feiyang Liu
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Affiliation High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, P.R. China
- Maria Nicolais
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Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Jianming Zhang
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Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
- Constantine Mitsiades
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Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Robert W. Smith
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Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Richard Stone
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Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Ilene Galinsky
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Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Atsushi Nonami
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Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- James D. Griffin
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* E-mail: ellen_weisberg@dfci.harvard.edu (EW); james_griffin@dfci.harvard.edu (JDG)
Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
- Nathanael Gray
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Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
Competing Interests
JDG has a financial interest with Novartis Pharma AG. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Responsible for generation of research findings reported in paper (design/performance of experiments), integrity and analysis of the data, writing of the manuscript: EW. Responsible for generation of research findings reported in paper (design/performance of experiments), integrity and analysis of the data, editing of the manuscript: QL. Performed Akt, GSKbeta, tubulin immunoblotting experiments: XZ. Assisted with proliferation studies: EN. Offered valuable scientific feedback and helped with conception of research reported in paper: MS. Assisted with the chemical screening: FL MN JZ AN. Offered valuable scientific feedback and helped with conception of research reported in paper: CM. Carried out flow cytometry analysis and helped with cell cycle and apoptosis studies: RWS. Provided AML patient samples used in this study as well as patient information: RS IG. Responsible for conception of research reported in paper, integrity and analysis of the data: JDG NG. Conceived and designed the experiments: EW QL MS CM AN JDG NG. Performed the experiments: EW XZ EN FL MN. Analyzed the data: EW QL RWS. Contributed reagents/materials/analysis tools: JZ RS IG. Wrote the paper: EW QL MS.