About the Authors

Ellen Weisberg

Contributed equally to this work with: Ellen Weisberg, Qingsong Liu

ellen_weisberg@dfci.harvard.edu (EW); james_griffin@dfci.harvard.edu (JDG)

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Qingsong Liu

Contributed equally to this work with: Ellen Weisberg, Qingsong Liu

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

Xin Zhang

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

Erik Nelson

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Martin Sattler

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Feiyang Liu

Affiliation High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, P.R. China

Maria Nicolais

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Jianming Zhang

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

Constantine Mitsiades

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Robert W. Smith

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Richard Stone

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Ilene Galinsky

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Atsushi Nonami

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

James D. Griffin

ellen_weisberg@dfci.harvard.edu (EW); james_griffin@dfci.harvard.edu (JDG)

Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Nathanael Gray

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

JDG has a financial interest with Novartis Pharma AG. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Responsible for generation of research findings reported in paper (design/performance of experiments), integrity and analysis of the data, writing of the manuscript: EW. Responsible for generation of research findings reported in paper (design/performance of experiments), integrity and analysis of the data, editing of the manuscript: QL. Performed Akt, GSKbeta, tubulin immunoblotting experiments: XZ. Assisted with proliferation studies: EN. Offered valuable scientific feedback and helped with conception of research reported in paper: MS. Assisted with the chemical screening: FL MN JZ AN. Offered valuable scientific feedback and helped with conception of research reported in paper: CM. Carried out flow cytometry analysis and helped with cell cycle and apoptosis studies: RWS. Provided AML patient samples used in this study as well as patient information: RS IG. Responsible for conception of research reported in paper, integrity and analysis of the data: JDG NG. Conceived and designed the experiments: EW QL MS CM AN JDG NG. Performed the experiments: EW XZ EN FL MN. Analyzed the data: EW QL RWS. Contributed reagents/materials/analysis tools: JZ RS IG. Wrote the paper: EW QL MS.