About the Authors

Hervé Boutin

herve.boutin@manchester.ac.uk

Affiliations Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

Christian Prenant

Affiliation Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

Renaud Maroy

Affiliation Service Hospitalier Frédéric Joliot – Commissariat à l'Energie Atomique, Orsay, France

James Galea

Affiliations Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom, Brain Injury Research Group, Manchester Academic Health Sciences Centre, Salford Royal NHS Foundation Trust, Salford, United Kingdom

Andrew D. Greenhalgh

Current address: Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Quebec, Canada

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Alison Smigova

Affiliation Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

Christopher Cawthorne

Affiliation Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

Peter Julyan

Affiliation North Western Medical Physics, Christie Hospital, Manchester, United Kingdom

Shane M. Wilkinson

Affiliation School of Chemistry, University of Sydney, Sydney, Australia

Samuel D. Banister

Affiliation School of Chemistry, University of Sydney, Sydney, Australia

Gavin Brown

Affiliation Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

Karl Herholz

Affiliation Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

Michael Kassiou

Affiliations School of Chemistry, University of Sydney, Sydney, Australia, Discipline of Medical Radiation Sciences, University of Sydney, Sydney, Australia, Brain and Mind Research Institute, University of Sydney, Sydney, Australia

Nancy J. Rothwell

Affiliation Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Competing Interests

NJR is a non-executive director of AstraZeneca plc but there was no involvement of the company in any aspect of the present study. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

PET imaging support: AS CC. Conceived and designed the experiments: HB MK. Performed the experiments: HB CP JG ADG. Analyzed the data: HB. Contributed reagents/materials/analysis tools: RM PJ SMW SDB GB MK. Wrote the paper: HB MK KH NJR.