About the Authors

Chunlei Zhang

Contributed equally to this work with: Chunlei Zhang, Chunsheng Zhang, Shengpei Chen, Xuyang Yin

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China

Chunsheng Zhang

Contributed equally to this work with: Chunlei Zhang, Chunsheng Zhang, Shengpei Chen, Xuyang Yin

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China

Shengpei Chen

Contributed equally to this work with: Chunlei Zhang, Chunsheng Zhang, Shengpei Chen, Xuyang Yin

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China, State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China

Xuyang Yin

Contributed equally to this work with: Chunlei Zhang, Chunsheng Zhang, Shengpei Chen, Xuyang Yin

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China

Xiaoyu Pan

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China

Ge Lin

Affiliations Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China, Key laboratory of Stem Cell and Reproductive Engineering, Ministry of Health, Changsha, China

Yueqiu Tan

Affiliations Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China, Key laboratory of Stem Cell and Reproductive Engineering, Ministry of Health, Changsha, China

Ke Tan

Affiliation Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China

Zhengfeng Xu

Affiliation Center of Prenatal Diagnosis, Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, China

Ping Hu

Affiliation Center of Prenatal Diagnosis, Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, China

Xuchao Li

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China

Fang Chen

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China, Department of Biology, University of Copenhagen, Copenhagen, Denmark

Xun Xu

Affiliation Science and Technology, BGI-Shenzhen, Shenzhen, China

Yingrui Li

Affiliation Science and Technology, BGI-Shenzhen, Shenzhen, China

Xiuqing Zhang

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China

Hui Jiang

jianghui@genomics.cn (HJ); wangw@genomics.cn (WW)

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China, Department of Biology, University of Copenhagen, Copenhagen, Denmark

Wei Wang

jianghui@genomics.cn (HJ); wangw@genomics.cn (WW)

Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China

Competing Interests

Chunlei Zhang, Chunsheng Zhang, Xuyang Yin, Xiaoyu Pan, Shengpei Chen, Hui Jiang and Xiuqing Zhang have filed patent applications on the method for copy number variation analysis by low coverage massively parallel sequencing at single cell level. The patent number is PCT/CN2012/070680 and the date is 2012-1-20. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: Chunlei Zhang SC XY. Performed the experiments: Chunlei Zhang Chunsheng Zhang XP. Analyzed the data: Chunlei Zhang Chunsheng Zhang. Contributed reagents/materials/analysis tools: GL YT KT ZX PH. Wrote the paper: Chunlei Zhang Chunsheng Zhang SC XY XL FC HJ. Supplied the direction for this study: FC HJ XX YL XZ WW.