About the Authors

Toshihiro Endo

Affiliation Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Masaki Kakeyama

kake@m.u-tokyo.ac.jp

Affiliation Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Yukari Uemura

Affiliation Department of Biostatistics, School of Public Health, The University of Tokyo, Tokyo, Japan

Asahi Haijima

Current address: Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

Affiliation Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Hiroyuki Okuno

Affiliation Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Haruhiko Bito

Affiliation Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Chiharu Tohyama

Affiliation Laboratory of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: TE YU MK. Wrote the paper: TE MK CT. Designed the research: TE HB CT MK. Performed the research: TE AH HO. Prepared arc antibody: HO HB. Prepared the others: MK CT.