About the Authors

Jan A. Graw

jan.graw@charite.de

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charité – Universitätsmedizin Berlin, Berlin, Germany

Claudia D. Spies

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charité – Universitätsmedizin Berlin, Berlin, Germany

Klaus-D. Wernecke

Affiliation Institute of Medical Biometry, Campus Charité Mitte, Charité - Universitätsmedizin Berlin and SOSTANA GmbH, Berlin, Germany

Jan-Peter Braun

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charité – Universitätsmedizin Berlin, Berlin, Germany

Competing Interests

KDW is employed by SOSTANA GmbH, Germany. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: JAG JPB. Performed the experiments: JAG. Analyzed the data: JAG KDW. Wrote the paper: JAG CDS KDW JPB. Interpreted the data: JAG CDS JPB.