About the Authors
- Selina Wray
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Affiliation Department of Molecular Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Matthew Self
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Affiliation Coriell Institute for Medical Research, Camden, New Jersey, United States of America
- NINDS Parkinson's Disease iPSC Consortium
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Affiliation For a full list of the members of the NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, and NINDS ALS iPSC Consortium please see the Acknowledgments section
- NINDS Huntington's Disease iPSC Consortium
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Affiliation For a full list of the members of the NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, and NINDS ALS iPSC Consortium please see the Acknowledgments section
- NINDS ALS iPSC Consortium
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Affiliation For a full list of the members of the NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, and NINDS ALS iPSC Consortium please see the Acknowledgments section
- Patrick A. Lewis
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Affiliation Department of Molecular Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Jan-Willem Taanman
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Affiliation Department of Clinical Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Natalie S. Ryan
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Affiliation Dementia Research Centre, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom
- Colin J. Mahoney
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Affiliation Dementia Research Centre, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom
- Yuying Liang
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Affiliation Dementia Research Centre, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom
- Michael J. Devine
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Affiliation Department of Molecular Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Una-Marie Sheerin
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Affiliation Department of Molecular Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Henry Houlden
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Affiliation Department of Molecular Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Huw R. Morris
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Affiliation Cardiff University School of Medicine, University of Cardiff, Cardiff, United Kingdom
- Daniel Healy
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Affiliation Department of Clinical Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Jose-Felix Marti-Masso
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Affiliation Hospital Donastia, San Sebastian, Spain
- Elisavet Preza
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Affiliation Department of Molecular Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Suzanne Barker
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Affiliation Dementia Research Centre, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom
- Margaret Sutherland
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Affiliation National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
- Roderick A. Corriveau
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Affiliation National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
- Michael D'Andrea
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Affiliation Coriell Institute for Medical Research, Camden, New Jersey, United States of America
- Anthony H. V. Schapira
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Affiliation Department of Clinical Neuroscience, University College London Institute of Neurology, London, United Kingdom
- Ryan J. Uitti
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Affiliation Departments of Neurology and Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America
- Mark Guttman
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Affiliation Department of Neurology, Center for Movement Disorders, Ontario, Canada
- Grzegorz Opala
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Affiliation Department of Neurology, Medical University of Silesia, Katowice, Poland
- Barbara Jasinska-Myga
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Affiliation Department of Neurology, Medical University of Silesia, Katowice, Poland
- Andreas Puschmann
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Affiliation Department of Geriatric Psychiatry, Lund University, Lund, Sweden
- Christer Nilsson
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Affiliation Department of Geriatric Psychiatry, Lund University, Lund, Sweden
- Alberto J. Espay
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Affiliation Department of Neurology, University of Cincinnati, Cincinnati, Ohio, United States of America
- Jaroslaw Slawek
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Affiliation Department of Neurological and Psychiatric Nursing, Medical University of Gdansk, Gdansk, Poland
- Ludwig Gutmann
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Affiliation Department of Neurology , West Virginia University, West Virginia, United States of America
- Bradley F. Boeve
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Affiliation Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
- Kevin Boylan
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Affiliation Departments of Neurology and Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America
- A. Jon Stoessl
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Affiliation Division of Neurology, Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
- Owen A. Ross
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Affiliation Departments of Neurology and Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America
- Nicholas J. Maragakis
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Affiliation Department of Neurology and Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
- Jay Van Gerpen
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Affiliation Departments of Neurology and Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America
- Melissa Gerstenhaber
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Affiliation Department of Psychiatry and Behavioural Sciences, John Hopkins University School of Medicine, Baltimore, Maryland, United States of America
- Katrina Gwinn
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Affiliation Baylor College of Medicine, Department of Genetics, Houston, Texas, United States of America
- Ted M. Dawson
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Affiliation Neuroregeneration Program, Institute of Cell Engineering, Department of Neurology and the Solomon H. Snyder Department of Neuroscience, John Hopkins University, Baltimore, Maryland, United States of America
- Ole Isacson
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Affiliation Center for Neuroregeneration Research, Harvard Medical School, Belmont, Massachusetts, United States of America
- Karen S. Marder
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Affiliation Department of Neurology, Psychiatry, Sergievsky Center, and Taub Institute, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
- Lorraine N. Clark
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Affiliation Department of Neurology, Psychiatry, Sergievsky Center, and Taub Institute, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
- Serge E. Przedborski
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Affiliation Center for Motor Neuron Biology and Diseases, Departments of Neurology, Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
- Steven Finkbeiner
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Affiliation Gladstone Institute of Neurological Disease, Taube-Koret Center for Huntington's Disease Research, Departments of Neurology and Physiology, University of California San Francisco, San Francisco, California, United States of America
- Jeffrey D. Rothstein
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Affiliation Department of Psychiatry and Behavioural Sciences, John Hopkins University School of Medicine, Baltimore, Maryland, United States of America
- Zbigniew K. Wszolek
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Affiliation Departments of Neurology and Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America
- Martin N. Rossor
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Affiliation Dementia Research Centre, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom
- John Hardy
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* E-mail: j.hardy@ucl.ac.uk
Affiliation Department of Molecular Neuroscience, University College London Institute of Neurology, London, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: JH MNR ZKW TMD KSM OI KG M. Self M. Sutherland SB. Performed the experiments: SW M. Self PAL JWT EP MJD LNC OAR. Analyzed the data: SW M. Self PAL JWT EP MJD LNC OAR. Contributed reagents/materials/analysis tools: NSR CJM UMS HH HRM DH JFMM AHVS RJU M. Guttman M. Gerstenhaber GO BJM AP CN AJE JS LG BB KB AJS NJM JVG TMD OI KSM SP SF JDR ZKW MNR YL. Wrote the paper: SW JH. Project management at NINDS repository: M. Sutherland RAC MD KG.