About the Authors
- Ian Tietjen
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Contributed equally to this work with: Ian Tietjen, G. Kees Hovingh
Affiliation Xenon Pharmaceuticals Inc., Burnaby, Canada
- G. Kees Hovingh
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Contributed equally to this work with: Ian Tietjen, G. Kees Hovingh
Affiliation Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
- Roshni R. Singaraja
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Affiliations Xenon Pharmaceuticals Inc., Burnaby, Canada, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada
- Chris Radomski
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Affiliation Xenon Pharmaceuticals Inc., Burnaby, Canada
- Amina Barhdadi
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Affiliation Montreal Heart Institute, Montréal, Canada
- Jason McEwen
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Affiliation Xenon Pharmaceuticals Inc., Burnaby, Canada
- Elden Chan
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Affiliation Xenon Pharmaceuticals Inc., Burnaby, Canada
- Maryanne Mattice
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Affiliation Xenon Pharmaceuticals Inc., Burnaby, Canada
- Annick Legendre
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Affiliation Xenon Pharmaceuticals Inc., Burnaby, Canada
- Patrick L. Franchini
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Affiliation Xenon Pharmaceuticals Inc., Burnaby, Canada
- Marie-Pierre Dubé
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Affiliation Montreal Heart Institute, Montréal, Canada
- John J. P. Kastelein
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Affiliation Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
- Michael R. Hayden
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* E-mail: mrh@cmmt.ubc.ca
Affiliation Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada
Competing Interests
Some of the authors of this work were employed by Xenon Pharmaceuticals, Inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: IT RS JJPK MRH. Performed the experiments: CR JM EC MM AL. Analyzed the data: AB EC M-PD IT RS PF. Contributed reagents/materials/analysis tools: GKH JJPK. Wrote the paper: IT JJPK MRH.