About the Authors

Frank P. Diekstra

Contributed equally to this work with: Frank P. Diekstra, Christiaan G. J. Saris, Leonard H. van den Berg, Jan H. Veldink

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Christiaan G. J. Saris

Contributed equally to this work with: Frank P. Diekstra, Christiaan G. J. Saris, Leonard H. van den Berg, Jan H. Veldink

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Wouter van Rheenen

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Lude Franke

Affiliation Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands

Ritsert C. Jansen

Affiliations Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands, Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

Michael A. van Es

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Paul W. J. van Vught

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Hylke M. Blauw

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Ewout J. N. Groen

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Steve Horvath

Affiliations Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biostatistics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Karol Estrada

Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

Fernando Rivadeneira

Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

Albert Hofman

Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

Andre G. Uitterlinden

Affiliation Department of Epidemiology and Biostatistics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

Wim Robberecht

Affiliations Department of Neurology, University Hospital Leuven, University of Leuven, Leuven, Belgium, Laboratory for Neurobiology, Vesalius Research Centre, Flanders Institute for Biotechnology (VIB), Leuven, Belgium

Peter M. Andersen

Affiliation Department of Clinical Neuroscience, Umeå University, Umeå, Sweden

Judith Melki

Affiliation Department of Neuropediatrics, University of Paris, Bicetre Hospital, Paris, France

Vincent Meininger

Affiliation Department of Neurology, Université Pierre et Marie Curie, Hôpital de la Salpêtrière, Paris, France

Orla Hardiman

Affiliations Department of Neurology, Beaumont Hospital, Dublin, Ireland, Department of Neurology, Trinity College, Dublin, Ireland

John E. Landers

Affiliations Department of Neurology, University of Massachusetts School of Medicine, Worcester, Massachusetts, United States of America, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Robert H. Brown Jr.

Affiliations Department of Neurology, University of Massachusetts School of Medicine, Worcester, Massachusetts, United States of America, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Aleksey Shatunov

Affiliation Medical Research Council Centre for Neurodegeneration Research, King’s College London, Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

Christopher E. Shaw

Affiliation Medical Research Council Centre for Neurodegeneration Research, King’s College London, Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

P. Nigel Leigh

Affiliation Medical Research Council Centre for Neurodegeneration Research, King’s College London, Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

Ammar Al-Chalabi

Affiliation Medical Research Council Centre for Neurodegeneration Research, King’s College London, Department of Clinical Neuroscience, Institute of Psychiatry, London, United Kingdom

Roel A. Ophoff

Affiliations Department of Medical Genetics, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands, Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America

Leonard H. van den Berg

Contributed equally to this work with: Frank P. Diekstra, Christiaan G. J. Saris, Leonard H. van den Berg, Jan H. Veldink

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Jan H. Veldink

Contributed equally to this work with: Frank P. Diekstra, Christiaan G. J. Saris, Leonard H. van den Berg, Jan H. Veldink

j.h.veldink@umcutrecht.nl

Affiliation Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JHV LHB FPD CGJS. Performed the experiments: MAE PWJV HMB EJNG. Analyzed the data: FPD CGJS JHV LF RCJ SH. Contributed reagents/materials/analysis tools: WR PMA KE FR AH AGU JM VM OH JEL RHB AS CES PNL AAC RAO. Wrote the paper: FPD JHV CGJS.