About the Authors

Kenta Jounai

Affiliations Central Laboratories for Frontier Technology, Kirin Holdings Co., Ltd., Kanazawa, Yokohama, Japan, Technical Development Center, Koiwai Dairy Foods Co., Ltd., Sayama, Japan

Kumiko Ikado

Affiliation Central Laboratories for Frontier Technology, Kirin Holdings Co., Ltd., Kanazawa, Yokohama, Japan

Tetsu Sugimura

Affiliation Central Laboratories for Frontier Technology, Kirin Holdings Co., Ltd., Kanazawa, Yokohama, Japan

Yasuhisa Ano

Affiliation Central Laboratories for Frontier Technology, Kirin Holdings Co., Ltd., Kanazawa, Yokohama, Japan

Jonathan Braun

Affiliation Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

Daisuke Fujiwara

d-fujiwara@kirin.co.jp

Affiliation Central Laboratories for Frontier Technology, Kirin Holdings Co., Ltd., Kanazawa, Yokohama, Japan

Competing Interests

The authors have read the journal's policy and have the following conflicts: More than one of the authors are employed by Kirin Holdings Co., Ltd. One of the authors is employed by Koiwai Dairy Foods Co., Ltd. However, Koiwai Dairy Foods Co., Ltd. is a subsidiary company of Kirin Holdings Co., Ltd. and whole research was executed at Kirin Holdings Co., Ltd. using Kirin’s sources under joint research agreement between Kirin and Koiwai, therefore this does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DF JB. Performed the experiments: KJ KI TS YA DF. Analyzed the data: KJ KI TS YA DF. Contributed reagents/materials/analysis tools: KJ KI TS YA DF. Wrote the paper: DF JB.