The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures

Ashwini Kamath-Loeb; Lawrence A. Loeb; Michael Fry

doi:10.1371/journal.pone.0030189

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Open Access

Peer-reviewed

Research Article

The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures

Ashwini Kamath-Loeb,

Affiliation Department of Pathology, The Gottstein Memorial Cancer Research Center, University of Washington, Seattle, Washington, United States of America
⨯
Lawrence A. Loeb,

Affiliation Department of Pathology, The Gottstein Memorial Cancer Research Center, University of Washington, Seattle, Washington, United States of America
⨯
Michael Fry

* E-mail: mickey@tx.technion.ac.il

Affiliation Department of Biochemistry, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel
⨯

The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA Structures

Ashwini Kamath-Loeb,
Lawrence A. Loeb,
Michael Fry

Published: January 17, 2012
https://doi.org/10.1371/journal.pone.0030189

About the Authors

Ashwini Kamath-Loeb

Affiliation Department of Pathology, The Gottstein Memorial Cancer Research Center, University of Washington, Seattle, Washington, United States of America

Lawrence A. Loeb

Affiliation Department of Pathology, The Gottstein Memorial Cancer Research Center, University of Washington, Seattle, Washington, United States of America

Michael Fry

* E-mail: mickey@tx.technion.ac.il

Affiliation Department of Biochemistry, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MF. Performed the experiments: MF AK-L. Analyzed the data: MF AK-L LAL. Wrote the paper: MF AK-L LAL.

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DNA structure
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Helicases
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DNA-binding proteins
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DNA electrophoresis
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Oligomers
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DNA annealing
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Gel electrophoresis
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DNA binding assay
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