About the Authors

Jiangang Liu

Affiliations Translational Science, Lilly Research Laboratories, a Division of Eli Lilly & Co., Indianapolis, Indiana, United States of America, School of Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

Robert A. Jolly

Affiliation Toxicology, Lilly Research Laboratories, a Division of Eli Lilly & Co., Indianapolis, Indiana, United States of America

Aaron T. Smith

Affiliation Toxicology, Lilly Research Laboratories, a Division of Eli Lilly & Co., Indianapolis, Indiana, United States of America

George H. Searfoss

Affiliation Toxicology, Lilly Research Laboratories, a Division of Eli Lilly & Co., Indianapolis, Indiana, United States of America

Keith M. Goldstein

Affiliation Toxicology, Lilly Research Laboratories, a Division of Eli Lilly & Co., Indianapolis, Indiana, United States of America

Vladimir N. Uversky

Affiliations Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, Department of Molecular Medicine, University of South Florida, Tampa, Florida, United States of America, Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

Keith Dunker

Affiliations School of Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America, Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

Shuyu Li

Affiliation Translational Science, Lilly Research Laboratories, a Division of Eli Lilly & Co., Indianapolis, Indiana, United States of America

Craig E. Thomas

weita@lilly.com (TW); cthomas@lilly.com (CET)

Affiliation Toxicology, Lilly Research Laboratories, a Division of Eli Lilly & Co., Indianapolis, Indiana, United States of America

Tao Wei

weita@lilly.com (TW); cthomas@lilly.com (CET)

Affiliation Translational Science, Lilly Research Laboratories, a Division of Eli Lilly & Co., Indianapolis, Indiana, United States of America

Competing Interests

JL, RAJ, AKS, GHS, KMG, SL, CET, and TW are employees of Eli Lilly and Company. This employment does not alter the authors' adherence to PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JL TW SL CET VNU KD. Performed the experiments: JL TW RAJ ATS GHS KMG. Analyzed the data: JL TW SL CET VNU KD RAJ ATS. Wrote the paper: JL TW CET.