Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques

Joonhoon Kim; Jennifer L. Reed; Christos T. Maravelias

doi:10.1371/journal.pone.0024162

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Peer-reviewed

Research Article

Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques

Joonhoon Kim,

Affiliations Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Jennifer L. Reed ,

* E-mail: reed@engr.wisc.edu (JLR); christos@engr.wisc.edu (CTM)

Affiliations Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Christos T. Maravelias

* E-mail: reed@engr.wisc.edu (JLR); christos@engr.wisc.edu (CTM)

Affiliations Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯

Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques

Joonhoon Kim,
Jennifer L. Reed,
Christos T. Maravelias

Published: September 9, 2011
https://doi.org/10.1371/journal.pone.0024162

About the Authors

Joonhoon Kim

Affiliations Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Jennifer L. Reed

* E-mail: reed@engr.wisc.edu (JLR); christos@engr.wisc.edu (CTM)

Christos T. Maravelias

* E-mail: reed@engr.wisc.edu (JLR); christos@engr.wisc.edu (CTM)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JK JLR CTM. Performed the experiments: JK. Analyzed the data: JK JLR CTM. Wrote the paper: JK JLR CTM.

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