About the Authors

Daniel Hain

Affiliation Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, United Kingdom

Brian R. Bettencourt

Affiliation Alnylam Pharmaceuticals, Cambridge, Massachusetts, United States of America

Katsutomo Okamura

Affiliation Sloan-Kettering Institute, Department of Developmental Biology, New York, New York, United States of America

Tibor Csorba

Current address: Agricultural Biotechnology Centre, Godollo, Hungary

Affiliation Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom

Wibke Meyer

Current address: Institute for Reference Materials and Measurements, Joint Research Centre European Commission, Geel, Belgium

Affiliation Institut für Genetik, Heinrich Heine Universität, Düsseldorf, Germany

Zhigang Jin

Affiliation Sloan-Kettering Institute, Department of Developmental Biology, New York, New York, United States of America

Jason Biggerstaff

Affiliation Boston University, Boston, Massachusetts, United States of America

Haruhiko Siomi

Affiliation Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan

Gyorgy Hutvagner

Affiliation Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom

Eric C. Lai

Affiliation Sloan-Kettering Institute, Department of Developmental Biology, New York, New York, United States of America

Michael Welte

Contributed equally to this work with: Michael Welte, H.-Arno J. Müller

Affiliation Department of Biology, University of Rochester, Rochester, New York, United States of America

H.-Arno J. Müller

Contributed equally to this work with: Michael Welte, H.-Arno J. Müller

h.j.muller@dundee.ac.uk

Affiliation Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, United Kingdom

Competing Interests

Dr. Bettencourt's employment with Alnylam does not alter his adherence to the PLoS ONE policies on sharing data and materials, as detailed online in PLoS's guide for authors, http://www.plosone.org/static/policies.action#sharing.

Author Contributions

Conceived and designed the experiments: DH BRB KO HS GH ECL MAW HAM. Performed the experiments: DH BRB KO TC WM ZJ JB MAW. Analyzed the data: DH BRB KO TC ZJ HS GH ECL MAW HAM. Contributed reagents/materials/analysis tools: BRB KO HS MAW HAM. Wrote the paper: BRB GH ECL MAW HAM.