Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells

Jing Xu; Jun-Ying Zhou; Wei-Zen Wei; Gen Sheng Wu

doi:10.1371/journal.pone.0010226

Loading metrics

Open Access

Peer-reviewed

Research Article

Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells

Jing Xu,

Affiliation Program in Molecular Biology & Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Jun-Ying Zhou,

Affiliation Program in Molecular Biology & Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Wei-Zen Wei,

Affiliation Program in Breast Cancer, Karmanos Cancer Institute, Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Gen Sheng Wu

* E-mail: wug@karmanos.org

Affiliation Program in Molecular Biology & Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯

Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells

Jing Xu,
Jun-Ying Zhou,
Wei-Zen Wei,
Gen Sheng Wu

Published: April 19, 2010
https://doi.org/10.1371/journal.pone.0010226

About the Authors

Jing Xu

Affiliation Program in Molecular Biology & Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Jun-Ying Zhou

Affiliation Program in Molecular Biology & Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Wei-Zen Wei

Affiliation Program in Breast Cancer, Karmanos Cancer Institute, Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Gen Sheng Wu

* E-mail: wug@karmanos.org

Affiliation Program in Molecular Biology & Genetics, Karmanos Cancer Institute, Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JX GSW. Performed the experiments: JX JYZ. Analyzed the data: JX GSW. Contributed reagents/materials/analysis tools: JX JYZ WZW GSW. Wrote the paper: JX WZW GSW.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Adenoviruses
Is the Subject Area "Adenoviruses" applicable to this article?

Thanks for your feedback.
Ovarian cancer
Is the Subject Area "Ovarian cancer" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.
Prostate cancer
Is the Subject Area "Prostate cancer" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.