About the Authors

Vincenzo Calvanese

Affiliation Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Angelica Horrillo

Affiliation Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Seville, Spain

Abdelkrim Hmadcha

Affiliation Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Seville, Spain

Beatriz Suarez-Álvarez

Affiliation Unidad de Histocompatibilidad, HUCA, Oviedo, Spain

Agustín F. Fernandez

Affiliations Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, Cancer Epigenetics and Biology Program (PEBC), Catalan Institute of Oncology (ICO), Barcelona, Spain

Ester Lara

Affiliation Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Sara Casado

Affiliation Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Pablo Menendez

Affiliation Andalusian Stem Cell Bank (BACM)/University of Granada, Instituto de Investigaciones Biomédicas, Parque Tecnológico de la Salud, Granada, Spain

Clara Bueno

Affiliation Andalusian Stem Cell Bank (BACM)/University of Granada, Instituto de Investigaciones Biomédicas, Parque Tecnológico de la Salud, Granada, Spain

Javier Garcia-Castro

Affiliation Andalusian Stem Cell Bank (BACM)/University of Granada, Instituto de Investigaciones Biomédicas, Parque Tecnológico de la Salud, Granada, Spain

Ruth Rubio

Affiliation Andalusian Stem Cell Bank (BACM)/University of Granada, Instituto de Investigaciones Biomédicas, Parque Tecnológico de la Salud, Granada, Spain

Pablo Lapunzina

Affiliation S. de Genética Médica y Molecular, Hospital Universitario La Paz, Madrid y CIBERER, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain

Miguel Alaminos

Affiliation Department of Histology, University of Granada, Granada, Spain

Lodovica Borghese

Affiliation Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany

Stefanie Terstegge

Affiliation Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany

Neil J. Harrison

Affiliation Centre for Stem Cell Biology and the Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom

Harry D. Moore

Affiliation Centre for Stem Cell Biology and the Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom

Oliver Brüstle

Affiliation Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany

Carlos Lopez-Larrea

Affiliation Unidad de Histocompatibilidad, HUCA, Oviedo, Spain

Peter W. Andrews

Affiliation Centre for Stem Cell Biology and the Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom

Bernat Soria

Affiliation Unidad de Histocompatibilidad, HUCA, Oviedo, Spain

Manel Esteller

mffraga@cnio.es (MFF); mesteller@cnio.es (ME)

Affiliations Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, Cancer Epigenetics and Biology Program (PEBC), Catalan Institute of Oncology (ICO), Barcelona, Spain

Mario F. Fraga

mffraga@cnio.es (MFF); mesteller@cnio.es (ME)

Affiliations Cancer Epigenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Darwin 3, Cantoblanco, Madrid, Spain

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MFF. Performed the experiments: VC AH AH BS AFF EL SC CB RR LB ST NJH. Analyzed the data: VC AH AFF MA. Contributed reagents/materials/analysis tools: AH AH BS PM JGC PL LB NJH HM OB CLL PA BS. Wrote the paper: PA BS ME MFF.