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KEGG pathway 04530

name Description Influence Expected SD z.score colouring Cldn2 claudin 2 1.3e+02 86.38 122.2 0.378 high in KO Pard6b par-6 (partitioning defective 6) homolog beta (C. elegans) 1.2e+02 49.73 70.3 0.928 high in KO Actb actin, beta, cytoplasmic 1.0e+02 20.58 29.1 2.887 high in WT Ppp2r3a protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha 8.1e+01 13.76 19.5 3.429 high in KO Prkcd protein kinase C, delta 7.8e+01 51.24 72.5 0.362 high in KO Gnai3 guanine nucleotide binding protein, alpha inhibiting 3 6.4e+01 12.14 17.2 3.019 high in WT Yes1 Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 6.3e+01 11.34 16.0 3.222 high in WT Cldn4 claudin 4 6.2e+01 16.23 23.0 2.011 high in KO Csnk2a2 casein kinase 2, alpha prime polypeptide 6.1e+01 10.67 15.1 3.332 high in KO B230120H23Rik RIKEN cDNA B230120H23 gene 5.6e+01 12.53 17.7 2.457 high in KO Prkce protein kinase C, epsilon 5.5e+01 22.77 32.2 1 high in KO Prkcb1 protein kinase C, beta 1 5.3e+01 9.68 13.7 3.155 high in KO F11r F11 receptor 5.2e+01 17.57 24.8 1.395 high in KO Myh14 myosin, heavy polypeptide 14 5.0e+01 25.13 35.5 0.707 high in KO Tjp3 tight junction protein 3 4.4e+01 19.33 27.3 0.915 high in KO Akt1 thymoma viral proto-oncogene 1 4.3e+01 9.62 13.6 2.438 high in KO Ctnna1 catenin (cadherin associated protein), alpha 1 4.2e+01 13.65 19.3 1.449 high in KO Nras neuroblastoma ras oncogene 4.2e+01 8.02 11.3 2.955 high in KO Cldn3 claudin 3 4.1e+01 11.85 16.8 1.748 high in KO Myh9 myosin, heavy polypeptide 9, non-muscle 3.7e+01 6.91 9.8 3.051 high in KO Epb4.1 erythrocyte protein band 4.1 3.6e+01 8.02 11.3 2.454 high in KO Prkch protein kinase C, eta 3.5e+01 5.96 8.4 3.502 high in KO Rhoa ras homolog gene family, member A 3.5e+01 34.58 48.9 0.007 high in KO Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform 3.4e+01 6.68 9.4 2.937 high in WT Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 3.4e+01 5.69 8.0 3.511 high in KO Cttn cortactin 3.4e+01 8.82 12.5 1.995 high in KO Prkcc protein kinase C, gamma 3.3e+01 5.55 7.9 3.541 high in WT Csda cold shock domain protein A 3.2e+01 9.20 13.0 1.767 high in KO Actn4 actinin alpha 4 3.1e+01 8.46 12.0 1.844 high in KO Tjp2 tight junction protein 2 2.9e+01 10.92 15.4 1.19 high in KO Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 2.7e+01 24.74 35.0 0.054 high in KO Pten phosphatase and tensin homolog 2.6e+01 6.29 8.9 2.236 high in WT Ppp2r1b protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform 2.6e+01 6.32 8.9 2.189 high in KO Cldn23 claudin 23 2.6e+01 15.80 22.3 0.449 high in KO Llgl1 lethal giant larvae homolog 1 (Drosophila) 2.5e+01 5.87 8.3 2.296 high in KO Gnai2 guanine nucleotide binding protein, alpha inhibiting 2 2.5e+01 6.89 9.7 1.844 high in KO Csnk2a1 casein kinase 2, alpha 1 polypeptide 2.5e+01 4.68 6.6 3.028 high in WT Inadl InaD-like (Drosophila) 2.3e+01 7.46 10.5 1.481 high in KO Jam2 junction adhesion molecule 2 2.3e+01 13.63 19.3 0.484 high in WT Spnb2 spectrin beta 2 2.2e+01 6.14 8.7 1.847 high in KO Cdk4 cyclin-dependent kinase 4 2.2e+01 31.08 43.9 -0.217 high in KO Ash1l ash1 (absent, small, or homeotic)-like (Drosophila) 2.1e+01 5.29 7.5 2.164 high in KO Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 1.8e+01 4.83 6.8 1.994 high in KO Cldn7 claudin 7 1.7e+01 5.64 8.0 1.44 high in KO Epb4.1l1 erythrocyte protein band 4.1-like 1 1.7e+01 5.28 7.5 1.52 high in KO Rras2 related RAS viral (r-ras) oncogene homolog 2 1.5e+01 7.60 10.7 0.72 high in WT Sympk symplekin 1.5e+01 3.25 4.6 2.58 high in KO Prkcz protein kinase C, zeta 1.4e+01 12.82 18.1 0.079 high in KO Jam3 junction adhesion molecule 3 1.3e+01 5.66 8.0 0.977 high in WT Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 1.3e+01 3.32 4.7 2.153 high in KO Hcls1 hematopoietic cell specific Lyn substrate 1 1.1e+01 2.44 3.4 2.475 high in KO Akt3 thymoma viral proto-oncogene 3 1.1e+01 6.52 9.2 0.479 high in WT Myh10 myosin, heavy polypeptide 10, non-muscle 1.1e+01 8.50 12.0 0.197 high in KO Cldn15 claudin 15 1.1e+01 3.22 4.5 1.606 high in KO Rab13 RAB13, member RAS oncogene family 8.6e+00 3.76 5.3 0.916 high in WT Cldn1 claudin 1 8.0e+00 2.14 3.0 1.954 high in WT Exoc3 exocyst complex component 3 8.0e+00 5.59 7.9 0.309 high in KO Prkca protein kinase C, alpha 8.0e+00 2.20 3.1 1.868 high in KO Mpp5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 7.3e+00 3.55 5.0 0.754 high in WT Ctnnb1 catenin (cadherin associated protein), beta 1 7.3e+00 1.55 2.2 2.638 high in KO Epb4.1l2 erythrocyte protein band 4.1-like 2 7.0e+00 2.26 3.2 1.47 high in KO Ppp2r2c protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform 6.9e+00 9.20 13.0 -0.178 high in WT Myl6 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle 6.3e+00 2.63 3.7 0.997 high in WT Ppp2r4 protein phosphatase 2A, regulatory subunit B (PR 53) 6.0e+00 2.22 3.1 1.219 high in WT Vapa vesicle-associated membrane protein, associated protein A 5.9e+00 2.72 3.8 0.836 high in WT Crb3 crumbs homolog 3 (Drosophila) 5.1e+00 1.25 1.8 2.173 high in KO Gnai1 guanine nucleotide binding protein, alpha inhibiting 1 4.6e+00 4.01 5.7 0.099 high in WT Tjap1 tight junction associated protein 1 4.3e+00 18.35 26.0 -0.542 high in KO Epb4.1l3 erythrocyte protein band 4.1-like 3 4.3e+00 1.17 1.7 1.86 high in KO Exoc4 exocyst complex component 4 4.1e+00 1.49 2.1 1.228 high in KO Llgl2 lethal giant larvae homolog 2 (Drosophila) 3.7e+00 3.32 4.7 0.071 high in KO Cdc42 cell division cycle 42 homolog (S. cerevisiae) 3.5e+00 0.70 1.0 2.823 high in WT Actg1 actin, gamma, cytoplasmic 1 3.5e+00 1.42 2.0 1.028 high in KO Csnk2b casein kinase 2, beta polypeptide 3.2e+00 1.28 1.8 1.062 high in KO Ppm1j protein phosphatase 1J 3.1e+00 20.01 28.3 -0.596 high in WT Prkci protein kinase C, iota 3.1e+00 1.39 2.0 0.858 high in KO Ppp2r2d protein phosphatase 2, regulatory subunit B, delta isoform 3.0e+00 1.77 2.5 0.48 high in WT Src Rous sarcoma oncogene 3.0e+00 11.98 16.9 -0.532 high in WT Tjp1 tight junction protein 1 2.4e+00 0.82 1.2 1.414 high in KO Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 1.9e+00 1.06 1.5 0.567 high in WT Akt2 thymoma viral proto-oncogene 2 1.7e+00 1.39 2.0 0.166 high in KO Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 1.5e+00 1.25 1.8 0.152 high in KO Jam4 junction adhesion molecule 4 9.9e-01 3.12 4.4 -0.482 high in WT Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 9.4e-01 0.28 0.4 1.629 high in KO 4930412D23Rik RIKEN cDNA 4930412D23 gene 7.4e-01 1.97 2.8 -0.443 high in WT Hras1 Harvey rat sarcoma virus oncogene 1 5.9e-01 1.73 2.5 -0.467 high in KO Rras Harvey rat sarcoma oncogene, subgroup R 4.9e-01 4.09 5.8 -0.622 high in WT Pard6a par-6 (partitioning defective 6,) homolog alpha (C. elegans) 4.5e-01 1.78 2.5 -0.528 high in KO Spna2 spectrin alpha 2 3.1e-01 1.22 1.7 -0.528 high in KO Ocln occludin 1.4e-02 5.48 7.7 -0.705 high in WT Pard6g par-6 partitioning defective 6 homolog gamma (C. elegans) 7.2e-03 1.39 2.0 -0.703 high in KO

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