File created with BiNGO (c) on Mar 13, 2010 at 1:18:43 PM ontology: process curator: GO Selected ontology file : jar:file:/Applications/Scientifici/Systems Biology/Cytoscape_v2.6.3/plugins/GOlorize2-4.jar!/GO_Biological_Process Selected annotation file : jar:file:/Applications/Scientifici/Systems Biology/Cytoscape_v2.6.3/plugins/GOlorize2-4.jar!/H_sapiens_default Discarded evidence codes : Overrepresentation Selected statistical test : Hypergeometric test Selected correction : Benjamini & Hochberg False Discovery Rate (FDR) correction Selected significance level : 0.05 Testing option : Test cluster versus whole annotation The selected cluster : MAP4K2 PRKDC AURKA FER AURKB TTN EPHB4 SRC EPHB2 PDPK1 CSNK2A1 PTK2B MAP3K2 PAK4 CAMK2D PRKAA1 CAMK2B YES1 CSK TEC PRKCA LYN BRAF CDC2 TGFBR1 HCK CDK5 CDK2 WEE1 TYK2 MAPK1 RPS6KA3 CSNK1D FYN GSK3B MAPK14 ARAF MAPK3 TNK1 ABL1 ABL2 No annotations were retrieved for the following entities: GO-ID p-value corr p-value x nX N Description Genes in test set 6468 3.8880E-54 2.0839E-51 40 607 41 13953 protein amino acid phosphorylation MAP4K2|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|TGFBR1|HCK|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 16310 4.6546E-51 1.2474E-48 40 721 41 13953 phosphorylation MAP4K2|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|TGFBR1|HCK|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 6796 2.4716E-47 3.3119E-45 40 889 41 13953 phosphate metabolism MAP4K2|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|TGFBR1|HCK|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 6793 2.4716E-47 3.3119E-45 40 889 41 13953 phosphorus metabolism MAP4K2|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|TGFBR1|HCK|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 6464 5.5883E-40 5.9906E-38 41 1557 41 13953 protein modification MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 43412 2.6184E-39 2.3391E-37 41 1616 41 13953 biopolymer modification MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 44267 8.4522E-28 6.4719E-26 41 3066 41 13953 cellular protein metabolism MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 44260 1.5627E-27 1.0470E-25 41 3112 41 13953 cellular macromolecule metabolism MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 19538 3.9292E-26 2.3401E-24 41 3365 41 13953 protein metabolism MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 43283 4.5468E-20 2.4371E-18 41 4722 41 13953 biopolymer metabolism MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 43170 1.5264E-14 7.4375E-13 41 6433 41 13953 macromolecule metabolism MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 7165 4.9000E-14 2.1887E-12 33 3381 41 13953 signal transduction MAP4K2|AURKA|FER|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2B|PRKAA1|YES1|CSK|TEC|PRKCA|LYN|BRAF|TGFBR1|HCK|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 7154 9.9131E-13 4.0872E-11 33 3731 41 13953 cell communication MAP4K2|AURKA|FER|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2B|PRKAA1|YES1|CSK|TEC|PRKCA|LYN|BRAF|TGFBR1|HCK|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 44238 5.1688E-12 1.9789E-10 41 7412 41 13953 primary metabolism MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 7242 6.4391E-12 2.3009E-10 21 1282 41 13953 intracellular signaling cascade PRKCA|LYN|BRAF|HCK|MAP4K2|AURKA|FER|SRC|TYK2|MAPK1|FYN|MAP3K2|MAPK14|ARAF|TNK1|PRKAA1|ABL1|YES1|CSK|ABL2|TEC 44237 1.5612E-11 5.2299E-10 41 7614 41 13953 cellular metabolism MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 8152 2.7865E-10 8.7858E-9 41 8167 41 13953 metabolism MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 7049 4.3516E-10 1.2958E-8 16 818 41 13953 cell cycle PRKCA|CDC2|AURKA|AURKB|TTN|CDK5|CDK2|WEE1|MAPK1|CSNK2A1|MAPK14|MAPK3|CAMK2D|CAMK2B|ABL1|CSK 278 5.5967E-8 1.5788E-6 9 264 41 13953 mitotic cell cycle CDC2|CAMK2D|CAMK2B|AURKA|AURKB|ABL1|TTN|WEE1|CDK2 7243 6.0222E-8 1.6140E-6 10 358 41 13953 protein kinase cascade PRKCA|MAPK1|LYN|FYN|MAP3K2|MAPK14|MAP4K2|PRKAA1|SRC|TEC 46777 2.1354E-7 5.4505E-6 5 46 41 13953 protein amino acid autophosphorylation CAMK2D|TNK1|CAMK2B|FER|TTN 16540 2.3845E-7 5.8096E-6 5 47 41 13953 protein autoprocessing CAMK2D|TNK1|CAMK2B|FER|TTN 18108 2.6561E-7 6.1898E-6 5 48 41 13953 peptidyl-tyrosine phosphorylation PRKCA|LYN|FYN|ABL1|ABL2 18212 3.2724E-7 7.3084E-6 5 50 41 13953 peptidyl-tyrosine modification PRKCA|LYN|FYN|ABL1|ABL2 48518 6.1853E-7 1.3261E-5 14 1020 41 13953 positive regulation of biological process PRKCA|LYN|TGFBR1|EPHB4|CDK5|CDK2|EPHB2|MAPK1|PTK2B|MAP3K2|FYN|MAPK14|PRKAA1|ABL1 48856 1.8913E-6 3.8991E-5 18 1885 41 13953 anatomical structure development LYN|BRAF|TGFBR1|HCK|MAP4K2|TTN|EPHB4|CDK5|EPHB2|MAPK1|RPS6KA3|FYN|MAPK14|PAK4|MAPK3|CAMK2D|TNK1|TEC 9719 3.3854E-6 6.6631E-5 8 319 41 13953 response to endogenous stimulus MAPK1|CSNK1D|LYN|CDC2|MAPK14|MAPK3|PRKDC|ABL1 16485 3.4807E-6 6.6631E-5 5 80 41 13953 protein processing CAMK2D|TNK1|CAMK2B|FER|TTN 51329 3.7018E-6 6.8419E-5 5 81 41 13953 interphase of mitotic cell cycle CDC2|CAMK2D|CAMK2B|ABL1|CDK2 51325 4.1768E-6 7.4626E-5 5 83 41 13953 interphase CDC2|CAMK2D|CAMK2B|ABL1|CDK2 6950 8.4245E-6 1.4228E-4 12 921 41 13953 response to stress PRKCA|MAPK1|CSNK1D|CDC2|PTK2B|MAPK14|MAPK3|MAP4K2|PRKDC|PRKAA1|ABL1|TTN 51674 8.7600E-6 1.4228E-4 8 363 41 13953 localization of cell PRKCA|FYN|MAPK14|TGFBR1|PAK4|CDK5|EPHB4|EPHB2 6928 8.7600E-6 1.4228E-4 8 363 41 13953 cell motility PRKCA|FYN|MAPK14|TGFBR1|PAK4|CDK5|EPHB4|EPHB2 40011 9.4895E-6 1.4960E-4 8 367 41 13953 locomotion PRKCA|FYN|MAPK14|TGFBR1|PAK4|CDK5|EPHB4|EPHB2 18193 1.0441E-5 1.5593E-4 5 100 41 13953 peptidyl-amino acid modification PRKCA|LYN|FYN|ABL1|ABL2 48468 1.0473E-5 1.5593E-4 8 372 41 13953 cell development CSNK2A1|FYN|TGFBR1|MAP4K2|TTN|CDK5|EPHB4|EPHB2 7167 1.1193E-5 1.6214E-4 7 267 41 13953 enzyme linked receptor protein signaling pathway PRKCA|PDPK1|PTK2B|TGFBR1|EPHB4|SRC|EPHB2 43119 1.1662E-5 1.6366E-4 11 789 41 13953 positive regulation of physiological process PRKCA|MAPK1|LYN|FYN|PTK2B|MAPK14|TGFBR1|PRKAA1|ABL1|CDK5|CDK2 7169 1.1908E-5 1.6366E-4 6 177 41 13953 transmembrane receptor protein tyrosine kinase signaling pathway PRKCA|PDPK1|PTK2B|EPHB4|SRC|EPHB2 7067 1.2297E-5 1.6478E-4 6 178 41 13953 mitosis CDC2|AURKA|AURKB|TTN|WEE1|CDK2 87 1.3105E-5 1.7133E-4 6 180 41 13953 M phase of mitotic cell cycle CDC2|AURKA|AURKB|TTN|WEE1|CDK2 74 1.3797E-5 1.7607E-4 9 512 41 13953 regulation of progression through cell cycle PRKCA|CSNK2A1|CDC2|MAPK14|MAPK3|ABL1|CSK|WEE1|CDK2 51726 1.4233E-5 1.7742E-4 9 514 41 13953 regulation of cell cycle PRKCA|CSNK2A1|CDC2|MAPK14|MAPK3|ABL1|CSK|WEE1|CDK2 7275 1.4649E-5 1.7845E-4 19 2404 41 13953 development LYN|BRAF|TGFBR1|HCK|MAP4K2|TTN|EPHB4|CDK5|EPHB2|MAPK1|RPS6KA3|CSNK2A1|FYN|MAPK14|PAK4|MAPK3|CAMK2D|TNK1|TEC 8151 1.6299E-5 1.9414E-4 41 10668 41 13953 cellular physiological process MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 6974 1.7876E-5 2.0829E-4 7 287 41 13953 response to DNA damage stimulus MAPK1|CSNK1D|CDC2|MAPK14|MAPK3|PRKDC|ABL1 7612 1.8637E-5 2.1254E-4 3 18 41 13953 learning FYN|EPHB4|EPHB2 9653 2.0791E-5 2.3199E-4 12 1007 41 13953 morphogenesis MAPK1|BRAF|FYN|MAPK14|PAK4|MAPK3|CAMK2D|TNK1|CDK5|EPHB4|TEC|EPHB2 48513 2.1208E-5 2.3199E-4 12 1009 41 13953 organ development MAPK1|RPS6KA3|BRAF|LYN|FYN|MAPK14|MAPK3|MAP4K2|TTN|CDK5|EPHB4|EPHB2 7610 2.3778E-5 2.5490E-4 7 300 41 13953 behavior PRKCA|MAPK1|FYN|MAPK14|FER|EPHB4|EPHB2 48170 2.5226E-5 2.6512E-4 2 3 41 13953 positive regulation of long-term neuronal synaptic plasticity EPHB4|EPHB2 51242 2.8060E-5 2.8923E-4 10 707 41 13953 positive regulation of cellular physiological process PRKCA|MAPK1|LYN|PTK2B|MAPK14|TGFBR1|PRKAA1|ABL1|CDK5|CDK2 50896 3.5905E-5 3.6311E-4 17 2084 41 13953 response to stimulus PRKCA|LYN|CDC2|MAP4K2|PRKDC|FER|TTN|EPHB4|EPHB2|MAPK1|CSNK1D|FYN|PTK2B|MAPK14|MAPK3|PRKAA1|ABL1 16477 3.8667E-5 3.8380E-4 6 218 41 13953 cell migration PRKCA|FYN|TGFBR1|CDK5|EPHB4|EPHB2 165 5.3057E-5 5.1707E-4 5 140 41 13953 MAPKKK cascade PRKCA|MAPK1|MAP3K2|MAP4K2|PRKAA1 50789 5.6380E-5 5.3964E-4 25 4276 41 13953 regulation of biological process AURKA|AURKB|EPHB4|EPHB2|CSNK2A1|MAP3K2|PTK2B|CAMK2D|PRKAA1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|TGFBR1|CDK5|CDK2|WEE1|MAPK1|FYN|MAPK14|MAPK3|TNK1|ABL1 279 6.1616E-5 5.7941E-4 6 237 41 13953 M phase CDC2|AURKA|AURKB|TTN|WEE1|CDK2 50791 8.7767E-5 8.1109E-4 23 3794 41 13953 regulation of physiological process PRKCA|LYN|BRAF|CDC2|TGFBR1|AURKA|CDK5|EPHB4|WEE1|CDK2|EPHB2|MAPK1|CSNK2A1|FYN|PTK2B|MAPK14|MAPK3|CAMK2D|TNK1|PRKAA1|ABL1|CSK|TEC 48522 9.7411E-5 8.8496E-4 10 819 41 13953 positive regulation of cellular process PRKCA|MAPK1|LYN|PTK2B|MAPK14|TGFBR1|PRKAA1|ABL1|CDK5|CDK2 6915 1.2091E-4 1.0801E-3 9 676 41 13953 apoptosis PRKCA|MAPK1|BRAF|CDC2|PTK2B|PRKDC|PRKAA1|ABL1|CDK5 48169 1.2543E-4 1.1021E-3 2 6 41 13953 regulation of long-term neuronal synaptic plasticity EPHB4|EPHB2 12501 1.3076E-4 1.1305E-3 9 683 41 13953 programmed cell death PRKCA|MAPK1|BRAF|CDC2|PTK2B|PRKDC|PRKAA1|ABL1|CDK5 51301 1.4834E-4 1.2621E-3 5 174 41 13953 cell division CDC2|AURKB|CDK5|WEE1|CDK2 81 1.7527E-4 1.4234E-3 2 7 41 13953 traversing start control point of mitotic cell cycle CDC2|CDK2 46324 1.7527E-4 1.4234E-3 2 7 41 13953 regulation of glucose import PRKCA|PRKAA1 46323 1.7527E-4 1.4234E-3 2 7 41 13953 glucose import PRKCA|PRKAA1 7148 1.9749E-4 1.5554E-3 7 420 41 13953 cell morphogenesis FYN|PAK4|CAMK2D|TNK1|CDK5|EPHB4|EPHB2 42770 1.9997E-4 1.5554E-3 3 39 41 13953 DNA damage response, signal transduction CDC2|MAPK14|ABL1 16265 2.0313E-4 1.5554E-3 9 724 41 13953 death PRKCA|MAPK1|BRAF|CDC2|PTK2B|PRKDC|PRKAA1|ABL1|CDK5 8219 2.0313E-4 1.5554E-3 9 724 41 13953 cell death PRKCA|MAPK1|BRAF|CDC2|PTK2B|PRKDC|PRKAA1|ABL1|CDK5 7172 2.9935E-4 2.2599E-3 2 9 41 13953 signal complex formation PTK2B|SRC 30154 3.0684E-4 2.2842E-3 10 942 41 13953 cell differentiation CSNK2A1|LYN|FYN|MAPK14|TGFBR1|MAP4K2|TTN|CDK5|EPHB4|EPHB2 42981 3.6718E-4 2.6692E-3 7 465 41 13953 regulation of apoptosis PRKCA|MAPK1|BRAF|CDC2|PRKAA1|ABL1|CDK5 7611 3.7158E-4 2.6692E-3 3 48 41 13953 learning and/or memory FYN|EPHB4|EPHB2 48168 3.7349E-4 2.6692E-3 2 10 41 13953 regulation of neuronal synaptic plasticity EPHB4|EPHB2 43067 3.9671E-4 2.7979E-3 7 471 41 13953 regulation of programmed cell death PRKCA|MAPK1|BRAF|CDC2|PRKAA1|ABL1|CDK5 84 5.4574E-4 3.7502E-3 2 12 41 13953 S phase of mitotic cell cycle CDC2|ABL1 51320 5.4574E-4 3.7502E-3 2 12 41 13953 S phase CDC2|ABL1 51094 6.1718E-4 4.1875E-3 3 57 41 13953 positive regulation of development MAPK14|EPHB4|EPHB2 48699 6.5293E-4 4.3746E-3 5 240 41 13953 generation of neurons FYN|TGFBR1|CDK5|EPHB4|EPHB2 42330 6.9840E-4 4.5652E-3 4 138 41 13953 taxis PRKCA|MAPK1|MAPK14|FER 6935 6.9840E-4 4.5652E-3 4 138 41 13953 chemotaxis PRKCA|MAPK1|MAPK14|FER 22008 8.5818E-4 5.5420E-3 5 255 41 13953 neurogenesis FYN|TGFBR1|CDK5|EPHB4|EPHB2 48167 1.1141E-3 7.0257E-3 2 17 41 13953 regulation of synaptic plasticity EPHB4|EPHB2 50769 1.1141E-3 7.0257E-3 2 17 41 13953 positive regulation of neurogenesis EPHB4|EPHB2 51244 1.2742E-3 7.9417E-3 20 3597 41 13953 regulation of cellular physiological process PRKCA|LYN|BRAF|CDC2|TGFBR1|AURKA|CDK5|WEE1|CDK2|MAPK1|CSNK2A1|PTK2B|MAPK14|MAPK3|CAMK2D|TNK1|PRKAA1|ABL1|CSK|TEC 80 1.3957E-3 8.5986E-3 2 19 41 13953 G1 phase of mitotic cell cycle CDC2|CDK2 7519 1.5950E-3 9.7151E-3 3 79 41 13953 striated muscle development MAPK14|TTN|CDK5 43405 1.6538E-3 9.9599E-3 3 80 41 13953 regulation of MAPK activity PRKCA|MAP3K2|PRKAA1 42221 1.6947E-3 1.0093E-2 6 441 41 13953 response to chemical stimulus PRKCA|MAPK1|LYN|MAPK14|FER|TTN 45764 1.8749E-3 1.0806E-2 2 22 41 13953 positive regulation of amino acid metabolism PRKCA|LYN 51318 1.8749E-3 1.0806E-2 2 22 41 13953 G1 phase CDC2|CDK2 1934 1.8749E-3 1.0806E-2 2 22 41 13953 positive regulation of protein amino acid phosphorylation PRKCA|LYN 7626 1.9072E-3 1.0875E-2 4 181 41 13953 locomotory behavior PRKCA|MAPK1|MAPK14|FER 16043 1.9858E-3 1.1204E-2 13 1871 41 13953 cell organization and biogenesis PRKDC|AURKA|TTN|EPHB4|CDK5|EPHB2|PDPK1|FYN|PAK4|CAMK2D|TNK1|ABL1|ABL2 8284 2.0251E-3 1.1307E-2 4 184 41 13953 positive regulation of cell proliferation LYN|PTK2B|TGFBR1|CDK2 30218 2.2318E-3 1.2083E-2 2 24 41 13953 erythrocyte differentiation LYN|MAPK14 51969 2.2318E-3 1.2083E-2 2 24 41 13953 regulation of transmission of nerve impulse EPHB4|EPHB2 50804 2.2318E-3 1.2083E-2 2 24 41 13953 regulation of synaptic transmission EPHB4|EPHB2 50770 2.4214E-3 1.2979E-2 2 25 41 13953 regulation of axonogenesis EPHB4|EPHB2 77 2.6183E-3 1.3578E-2 2 26 41 13953 DNA damage checkpoint CDC2|MAPK14 31644 2.6183E-3 1.3578E-2 2 26 41 13953 regulation of neurophysiological process EPHB4|EPHB2 15758 2.6183E-3 1.3578E-2 2 26 41 13953 glucose transport PRKCA|PRKAA1 9887 2.6789E-3 1.3578E-2 6 483 41 13953 organ morphogenesis MAPK1|BRAF|MAPK14|MAPK3|EPHB4|EPHB2 6263 2.7026E-3 1.3578E-2 3 95 41 13953 DNA-dependent DNA replication CDC2|ABL1|CDK2 30029 2.7899E-3 1.3578E-2 4 201 41 13953 actin filament-based process PDPK1|ABL1|TTN|ABL2 15749 2.8225E-3 1.3578E-2 2 27 41 13953 monosaccharide transport PRKCA|PRKAA1 50803 2.8225E-3 1.3578E-2 2 27 41 13953 regulation of synapse structure and function EPHB4|EPHB2 8645 2.8225E-3 1.3578E-2 2 27 41 13953 hexose transport PRKCA|PRKAA1 7582 2.8380E-3 1.3578E-2 41 12096 41 13953 physiological process MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 6816 2.8671E-3 1.3578E-2 3 97 41 13953 calcium ion transport FYN|CAMK2D|CAMK2B 45004 2.9384E-3 1.3578E-2 1 1 41 13953 DNA replication proofreading CDC2 115 2.9384E-3 1.3578E-2 1 1 41 13953 S-phase-specific transcription in mitotic cell cycle ABL1 46317 2.9384E-3 1.3578E-2 1 1 41 13953 regulation of glucosylceramide biosynthesis PRKAA1 46318 2.9384E-3 1.3578E-2 1 1 41 13953 negative regulation of glucosylceramide biosynthesis PRKAA1 45542 2.9384E-3 1.3578E-2 1 1 41 13953 positive regulation of cholesterol biosynthesis PRKAA1 31570 3.2527E-3 1.4775E-2 2 29 41 13953 DNA integrity checkpoint CDC2|MAPK14 7346 3.2527E-3 1.4775E-2 2 29 41 13953 regulation of progression through mitotic cell cycle CDC2|CDK2 30182 3.3787E-3 1.5218E-2 4 212 41 13953 neuron differentiation TGFBR1|CDK5|EPHB4|EPHB2 45005 3.4786E-3 1.5538E-2 2 30 41 13953 maintenance of fidelity during DNA-dependent DNA replication CDC2|ABL1 43065 3.6123E-3 1.5881E-2 4 216 41 13953 positive regulation of apoptosis PRKCA|MAPK1|ABL1|CDK5 8286 3.7116E-3 1.5881E-2 2 31 41 13953 insulin receptor signaling pathway PRKCA|PDPK1 19395 3.7116E-3 1.5881E-2 2 31 41 13953 fatty acid oxidation MAPK14|PRKAA1 8629 3.7116E-3 1.5881E-2 2 31 41 13953 induction of apoptosis by intracellular signals PRKCA|ABL1 51239 3.7332E-3 1.5881E-2 4 218 41 13953 regulation of organismal physiological process PRKCA|FYN|EPHB4|EPHB2 43068 3.7332E-3 1.5881E-2 4 218 41 13953 positive regulation of programmed cell death PRKCA|MAPK1|ABL1|CDK5 50794 3.8237E-3 1.6138E-2 20 3914 41 13953 regulation of cellular process PRKCA|LYN|BRAF|CDC2|TGFBR1|AURKA|CDK5|WEE1|CDK2|MAPK1|CSNK2A1|PTK2B|MAPK14|MAPK3|CAMK2D|TNK1|PRKAA1|ABL1|CSK|TEC 50730 3.9517E-3 1.6548E-2 2 32 41 13953 regulation of peptidyl-tyrosine phosphorylation PRKCA|LYN 8283 4.0520E-3 1.6836E-2 7 704 41 13953 cell proliferation LYN|PTK2B|TGFBR1|CSK|CDK5|EPHB4|CDK2 50767 4.1988E-3 1.7312E-2 2 33 41 13953 regulation of neurogenesis EPHB4|EPHB2 16055 4.5176E-3 1.8484E-2 3 114 41 13953 Wnt receptor signaling pathway CSNK2A1|CSNK1D|GSK3B 82 4.7141E-3 1.9142E-2 2 35 41 13953 G1/S transition of mitotic cell cycle CAMK2D|CAMK2B 6281 5.2490E-3 2.1028E-2 4 240 41 13953 DNA repair CSNK1D|CDC2|PRKDC|ABL1 1932 5.2571E-3 2.1028E-2 2 37 41 13953 regulation of protein amino acid phosphorylation PRKCA|LYN 6521 5.5389E-3 2.1991E-2 2 38 41 13953 regulation of amino acid metabolism PRKCA|LYN 7409 5.7095E-3 2.2308E-2 3 124 41 13953 axonogenesis CDK5|EPHB4|EPHB2 45940 5.8684E-3 2.2308E-2 1 2 41 13953 positive regulation of steroid metabolism PRKAA1 46889 5.8684E-3 2.2308E-2 1 2 41 13953 positive regulation of lipid biosynthesis PRKAA1 51055 5.8684E-3 2.2308E-2 1 2 41 13953 negative regulation of lipid biosynthesis PRKAA1 6679 5.8684E-3 2.2308E-2 1 2 41 13953 glucosylceramide biosynthesis PRKAA1 2026 5.8684E-3 2.2308E-2 1 2 41 13953 cardiac inotropy PRKCA 48812 6.2342E-3 2.3205E-2 3 128 41 13953 neurite morphogenesis CDK5|EPHB4|EPHB2 48858 6.2342E-3 2.3205E-2 3 128 41 13953 cell projection morphogenesis CDK5|EPHB4|EPHB2 48667 6.2342E-3 2.3205E-2 3 128 41 13953 neuron morphogenesis during differentiation CDK5|EPHB4|EPHB2 42127 7.0549E-3 2.6079E-2 5 415 41 13953 regulation of cell proliferation LYN|PTK2B|TGFBR1|CSK|CDK2 7498 7.3711E-3 2.7061E-2 2 44 41 13953 mesoderm development HCK|TEC 904 7.9778E-3 2.9089E-2 3 140 41 13953 cellular morphogenesis during differentiation CDK5|EPHB4|EPHB2 42325 8.0348E-3 2.9099E-2 2 46 41 13953 regulation of phosphorylation PRKCA|LYN 7166 8.0996E-3 2.9137E-2 11 1694 41 13953 cell surface receptor linked signal transduction PRKCA|PDPK1|CSNK2A1|CSNK1D|PTK2B|MAPK14|GSK3B|TGFBR1|EPHB4|SRC|EPHB2 15674 8.7809E-3 2.9819E-2 3 145 41 13953 di-, tri-valent inorganic cation transport FYN|CAMK2D|CAMK2B 31175 8.7809E-3 2.9819E-2 3 145 41 13953 neurite development CDK5|EPHB4|EPHB2 45722 8.7901E-3 2.9819E-2 1 3 41 13953 positive regulation of gluconeogenesis PRKAA1 45833 8.7901E-3 2.9819E-2 1 3 41 13953 negative regulation of lipid metabolism PRKAA1 43525 8.7901E-3 2.9819E-2 1 3 41 13953 positive regulation of neuron apoptosis CDK5 46325 8.7901E-3 2.9819E-2 1 3 41 13953 negative regulation of glucose import PRKCA 6678 8.7901E-3 2.9819E-2 1 3 41 13953 glucosylceramide metabolism PRKAA1 45540 8.7901E-3 2.9819E-2 1 3 41 13953 regulation of cholesterol biosynthesis PRKAA1 46476 8.7901E-3 2.9819E-2 1 3 41 13953 glycosylceramide biosynthesis PRKAA1 187 9.0788E-3 3.0225E-2 2 49 41 13953 activation of MAPK activity MAP3K2|PRKAA1 51174 9.0788E-3 3.0225E-2 2 49 41 13953 regulation of phosphorus metabolism PRKCA|LYN 19220 9.0788E-3 3.0225E-2 2 49 41 13953 regulation of phosphate metabolism PRKCA|LYN 8643 9.8068E-3 3.2447E-2 2 51 41 13953 carbohydrate transport PRKCA|PRKAA1 7517 1.0526E-2 3.4513E-2 3 155 41 13953 muscle development MAPK14|TTN|CDK5 43406 1.0560E-2 3.4513E-2 2 53 41 13953 positive regulation of MAPK activity MAP3K2|PRKAA1 75 1.0946E-2 3.5557E-2 2 54 41 13953 cell cycle checkpoint CDC2|MAPK14 7010 1.1029E-2 3.5612E-2 5 463 41 13953 cytoskeleton organization and biogenesis PDPK1|AURKA|ABL1|TTN|ABL2 6916 1.1468E-2 3.5846E-2 3 160 41 13953 anti-apoptosis BRAF|CDC2|PRKAA1 46627 1.1703E-2 3.5846E-2 1 4 41 13953 negative regulation of insulin receptor signaling pathway PRKCA 6287 1.1703E-2 3.5846E-2 1 4 41 13953 base-excision repair, gap-filling CDC2 7181 1.1703E-2 3.5846E-2 1 4 41 13953 transforming growth factor beta receptor complex assembly TGFBR1 7095 1.1703E-2 3.5846E-2 1 4 41 13953 mitotic G2 checkpoint CDC2 6111 1.1703E-2 3.5846E-2 1 4 41 13953 regulation of gluconeogenesis PRKAA1 46326 1.1703E-2 3.5846E-2 1 4 41 13953 positive regulation of glucose import PRKAA1 46321 1.1703E-2 3.5846E-2 1 4 41 13953 positive regulation of fatty acid oxidation PRKAA1 46320 1.1703E-2 3.5846E-2 1 4 41 13953 regulation of fatty acid oxidation PRKAA1 50793 1.1858E-2 3.6114E-2 3 162 41 13953 regulation of development MAPK14|EPHB4|EPHB2 7254 1.2551E-2 3.8007E-2 2 58 41 13953 JNK cascade MAP3K2|MAP4K2 48666 1.2868E-2 3.8747E-2 3 167 41 13953 neuron development CDK5|EPHB4|EPHB2 31098 1.2967E-2 3.8829E-2 2 59 41 13953 stress-activated protein kinase signaling pathway MAP3K2|MAP4K2 7399 1.3109E-2 3.9036E-2 6 673 41 13953 nervous system development RPS6KA3|FYN|TGFBR1|CDK5|EPHB4|EPHB2 19226 1.3817E-2 4.0695E-2 4 318 41 13953 transmission of nerve impulse MAPK1|FYN|EPHB4|EPHB2 8040 1.3818E-2 4.0695E-2 2 61 41 13953 axon guidance EPHB4|EPHB2 31325 1.4110E-2 4.1210E-2 4 320 41 13953 positive regulation of cellular metabolism PRKCA|LYN|MAPK14|PRKAA1 30097 1.4582E-2 4.1210E-2 3 175 41 13953 hemopoiesis LYN|MAPK14|MAP4K2 42541 1.4608E-2 4.1210E-2 1 5 41 13953 hemoglobin biosynthesis LYN 731 1.4608E-2 4.1210E-2 1 5 41 13953 DNA synthesis during DNA repair CDC2 43255 1.4608E-2 4.1210E-2 1 5 41 13953 regulation of carbohydrate biosynthesis PRKAA1 6677 1.4608E-2 4.1210E-2 1 5 41 13953 glycosylceramide metabolism PRKAA1 50810 1.4608E-2 4.1210E-2 1 5 41 13953 regulation of steroid biosynthesis PRKAA1 46580 1.4608E-2 4.1210E-2 1 5 41 13953 negative regulation of Ras protein signal transduction TNK1 48731 1.5469E-2 4.3410E-2 6 698 41 13953 system development RPS6KA3|FYN|TGFBR1|CDK5|EPHB4|EPHB2 30036 1.6421E-2 4.4257E-2 3 183 41 13953 actin cytoskeleton organization and biogenesis PDPK1|ABL1|ABL2 30030 1.6659E-2 4.4257E-2 3 184 41 13953 cell projection organization and biogenesis CDK5|EPHB4|EPHB2 6917 1.6900E-2 4.4257E-2 3 185 41 13953 induction of apoptosis PRKCA|MAPK1|ABL1 12502 1.7142E-2 4.4257E-2 3 186 41 13953 induction of programmed cell death PRKCA|MAPK1|ABL1 6260 1.7387E-2 4.4257E-2 3 187 41 13953 DNA replication CDC2|ABL1|CDK2 48534 1.7387E-2 4.4257E-2 3 187 41 13953 hemopoietic or lymphoid organ development LYN|MAPK14|MAP4K2 9893 1.7431E-2 4.4257E-2 4 341 41 13953 positive regulation of metabolism PRKCA|LYN|MAPK14|PRKAA1 31572 1.7505E-2 4.4257E-2 1 6 41 13953 G2/M transition DNA damage checkpoint CDC2 31576 1.7505E-2 4.4257E-2 1 6 41 13953 G2/M transition checkpoint CDC2 46626 1.7505E-2 4.4257E-2 1 6 41 13953 regulation of insulin receptor signaling pathway PRKCA 45763 1.7505E-2 4.4257E-2 1 6 41 13953 negative regulation of amino acid metabolism PRKCA 45913 1.7505E-2 4.4257E-2 1 6 41 13953 positive regulation of carbohydrate metabolism PRKAA1 45923 1.7505E-2 4.4257E-2 1 6 41 13953 positive regulation of fatty acid metabolism PRKAA1 30239 1.7505E-2 4.4257E-2 1 6 41 13953 myofibril assembly TTN 55001 1.7505E-2 4.4257E-2 1 6 41 13953 muscle cell development TTN 55002 1.7505E-2 4.4257E-2 1 6 41 13953 striated muscle cell development TTN 20027 1.7505E-2 4.4257E-2 1 6 41 13953 hemoglobin metabolism LYN 51058 1.7505E-2 4.4257E-2 1 6 41 13953 negative regulation of small GTPase mediated signal transduction TNK1 8354 1.7505E-2 4.4257E-2 1 6 41 13953 germ cell migration TGFBR1 46513 1.7505E-2 4.4257E-2 1 6 41 13953 ceramide biosynthesis PRKAA1 1933 1.7505E-2 4.4257E-2 1 6 41 13953 negative regulation of protein amino acid phosphorylation PRKCA 6259 1.8002E-2 4.5300E-2 6 722 41 13953 DNA metabolism CSNK1D|CDC2|PRKDC|AURKB|ABL1|CDK2 9987 1.8743E-2 4.6945E-2 41 12665 41 13953 cellular process MAP4K2|PRKDC|AURKA|AURKB|FER|TTN|EPHB4|SRC|EPHB2|PDPK1|CSNK2A1|MAP3K2|PTK2B|PAK4|CAMK2D|PRKAA1|CAMK2B|YES1|CSK|TEC|PRKCA|LYN|BRAF|CDC2|HCK|TGFBR1|CDK5|WEE1|CDK2|TYK2|MAPK1|RPS6KA3|CSNK1D|FYN|MAPK14|GSK3B|MAPK3|ARAF|TNK1|ABL1|ABL2 45859 1.8895E-2 4.7106E-2 3 193 41 13953 regulation of protein kinase activity PRKCA|MAP3K2|PRKAA1 2520 1.9413E-2 4.7713E-2 3 195 41 13953 immune system development LYN|MAPK14|MAP4K2 43066 1.9413E-2 4.7713E-2 3 195 41 13953 negative regulation of apoptosis BRAF|CDC2|PRKAA1 43549 1.9676E-2 4.7713E-2 3 196 41 13953 regulation of kinase activity PRKCA|MAP3K2|PRKAA1 43069 2.0206E-2 4.7713E-2 3 198 41 13953 negative regulation of programmed cell death BRAF|CDC2|PRKAA1 45648 2.0393E-2 4.7713E-2 1 7 41 13953 positive regulation of erythrocyte differentiation MAPK14 42531 2.0393E-2 4.7713E-2 1 7 41 13953 positive regulation of tyrosine phosphorylation of STAT protein LYN 46890 2.0393E-2 4.7713E-2 1 7 41 13953 regulation of lipid biosynthesis PRKAA1 6109 2.0393E-2 4.7713E-2 1 7 41 13953 regulation of carbohydrate metabolism PRKAA1 50927 2.0393E-2 4.7713E-2 1 7 41 13953 positive regulation of positive chemotaxis PRKCA 50926 2.0393E-2 4.7713E-2 1 7 41 13953 regulation of positive chemotaxis PRKCA 50918 2.0393E-2 4.7713E-2 1 7 41 13953 positive chemotaxis PRKCA 50930 2.0393E-2 4.7713E-2 1 7 41 13953 induction of positive chemotaxis PRKCA 46427 2.0393E-2 4.7713E-2 1 7 41 13953 positive regulation of JAK-STAT cascade LYN 46520 2.0393E-2 4.7713E-2 1 7 41 13953 sphingoid biosynthesis PRKAA1 51338 2.0474E-2 4.7713E-2 3 199 41 13953 regulation of transferase activity PRKCA|MAP3K2|PRKAA1