Text S3 - Multiple sequence alignment used for CSL sequence partitioning Division into N-terminus, core (NTD+BTD+betaC4 linker) and C-terminus (CTD+tail) based on C. elegans crystal structure (Kovall and Hendrickson, 2004) Alignment coordinates: N 1-829 (...MIDFL) core 830-1756 (SNKEKYE....FFEAMG) C 1757-2134 CLUSTAL 2.0.12 multiple sequence alignment Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 ------------------------------------------------------------ Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 ------------------------------------------------------------ Lb_F2 ------------------------------------------------------------ Pc_F2 ------------------------------------------------------------ Pp_F2 ------------------------------------------------------------ Um_F2 MFQPTWSQEAHAQPPHQLHPQEGSSLPKDMQLPQQIQYDPSQISHQAPVHQLSEYDASIS Ml_F2 ------------------------------------------------------------ Ro_F2_a ------------------------------------------------------------ Ro_F2_b ------------------------------------------------------------ Pb_F2_a ------------------------------------------------------------ Ro_F2_c ------------------------------------------------------------ Pb_F2_c ------------------------------------------------------------ Ro_F2_d ------------------------------------------------------------ Pb_F2_b ------------------------------------------------------------ Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 ------------------------------------------------------------ So_F2 ------------------------------------------------------------ Cn_F2 ------------------------------------------------------------ Sj_F2 ------------------------------------------------------------ Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 ------------------------------------------------------------ Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 ------------------------------------------------------------ Lb_F2 ------------------------------------------------------------ Pc_F2 ------------------------------------------------------------ Pp_F2 ------------------------------------------------------------ Um_F2 QLPNAAPPDPSAYPFSIQPQQHRDTHLAHNDPPYSIAQQHNRFDDPMSASADLSAARPDS Ml_F2 ------------------------------------------------------------ Ro_F2_a ------------------------------------------------------------ Ro_F2_b ------------------------------------------------------------ Pb_F2_a ------------------------------------------------------------ Ro_F2_c ------------------------------------------------------------ Pb_F2_c ------------------------------------------------------------ Ro_F2_d ------------------------------------------------------------ Pb_F2_b ------------------------------------------------------------ Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 ------------------------------------------------------------ So_F2 ------------------------------------------------------------ Cn_F2 ------------------------------------------------------------ Sj_F2 ------------------------------------------------------------ Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 ------------------------------------------------------------ Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 ------------------------------------------------------------ Lb_F2 ------------------------------------------------------------ Pc_F2 ------------------------------------------------------------ Pp_F2 ------------------------------------------------------------ Um_F2 MQSVASLYLDGQTMSVDNASLDLGTSHHSNDYLAQHDDPSRSRPPTGSEQNWSHHTLPSN Ml_F2 ------------------------------------------------------------ Ro_F2_a ------------------------------------------------------------ Ro_F2_b ------------------------------------------------------------ Pb_F2_a ------------------------------------------------------------ Ro_F2_c ------------------------------------------------------------ Pb_F2_c ------------------------------------------------------------ Ro_F2_d ------------------------------------------------------------ Pb_F2_b ------------------------------------------------------------ Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 ------------------------------------------------------------ So_F2 ------------------------------------------------------------ Cn_F2 ------------------------------------------------------------ Sj_F2 ------------------------------------------------------------ Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 ------------------------------------------------------------ Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 ------------------------------------------------------------ Lb_F2 ------------------------------------------------------------ Pc_F2 ------------------------------------------------------------ Pp_F2 ------------------------------------------------------------ Um_F2 QAHHDASATGALAGPHRAARPAALKIDMPSVVSRGVHDTTASTGTDPVSAEPGSATTPHA Ml_F2 ------------MSNYLYPSSTETSSYSTELNSHNTNDQSTPWHPHSWSATPDPPSAQTI Ro_F2_a ------------------------------------------------------------ Ro_F2_b ------------------------------------------------------------ Pb_F2_a ------------------------------------------------------------ Ro_F2_c ------------------------------------------------------------ Pb_F2_c ------------------------------------------------------------ Ro_F2_d -------------------------------MTGIPPQHDIIKH-------SIIFHNNDT Pb_F2_b -------------------------------MPSMADSTSSPSYGCSSQPLSPEMQNNRK Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 -------------------------------------------------------MSPNV So_F2 -------------------------------------------------------MNPRR Cn_F2 ------------------------------------------------------------ Sj_F2 ------------------------------------------------------------ Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 ------------------------------------------------------------ Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 ----------------------------------------------------------MA Lb_F2 -----------------------------------------------------------M Pc_F2 ----MAQTSATSSGYSSWLPLSANAGAERRSMEHGLTTAVSPADILKPPSAPRSARHRSM Pp_F2 ----MAST--------AWLAMHS-ATPDRR----------SEFDLLKNPPAHHYARERKM Um_F2 LQTRFAPLPQLPPSMYDNQPMLQQHSDSANSTTMHDAPASSGSALMPAFGTESAYFAQAS Ml_F2 QDQLYHQAEAELDPELSGSPRKSSNHLSHSRSYPTLLQPHPISDDASPNPLLSSLRSGSV Ro_F2_a ------------------------------------------------------------ Ro_F2_b ------------------------------------------------------------ Pb_F2_a ------------------------------------------------------------ Ro_F2_c -----------------------------------------------------------M Pb_F2_c -------------------------------------------------------MYDAM Ro_F2_d KPQPPSPE-------------------------------------------------TPT Pb_F2_b RKQLQYPTSVDNSPYMNIPYPPAQWSTDPYATHSSIGYTTEKPDMMSWPSTQFDPRSTST Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 QKRPSSEDIKTQEFYDSTRNIRRVATAIGSINANLESPQLYSLAKSTSLQEPVRIYGDSV So_F2 FRHYSFEKLSPSSFQEYSSEARNVTEPYPPIETHSPQNSFTSMLNSFPFGKDDQLSSNSS Cn_F2 ---------------------------------------------------------MSY Sj_F2 -----------------------------------------------MSGLKNHSPYGIA Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 ------------------------------------------------------------ Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 SLDFASAPPPAQHSLYPQPSDLDGANFNLPHSETVGVFP--PLRTD--FPADTKYRQSDQ Lb_F2 SLDFPSGNGQPPHSLYSQP-DLDQP-FNMHNSDSSSTSPSHPHIGG--SLQQHTYDHPDR Pc_F2 SIDFT--PTGPHQSMFAQP-DIDQPFSSLQG-------GDLAHSGSHMSVGGHPLDRNDP Pp_F2 SMDFS--PSGTPQGIYAQP-DLDHSFGSLQSPADMSAPQQNAHNGGHMHMSAHSLDRVDA Um_F2 ALGSPALAHQAPDHILNSPRLHQAESLAGVPGVPERLGPSAAHLGVAVSPSSPMMSQLSA Ml_F2 GLDIPQPAGHFTSYSFEHN--LFQPSHHSHQQGSSLIPSLPSHQNQLHGSPSRLRTYSDA Ro_F2_a ------------------------------------------MNDPELLSNDEADL---- Ro_F2_b ------------------------------------------MNYPELLTN--------- Pb_F2_a -MTTLNNCEL----------------------TDTSRKRKQEFNDPKYLTPWSDYMDSNS Ro_F2_c FTTETRKRKQ----------------------DEMNTTLPTNWTDFIYSTPSSP------ Pb_F2_c FDSFCRKRKL----------------------EDT------QWSDYVYSSPSSPVP---- Ro_F2_d SSSSSRKRKQ-----------------DFQFTPDHLS-----FPQYNYAEPET------- Pb_F2_b STPESRVRQPSSTSSATVDIDDLFDQIDPTLIPGTSSNPARSFYVYDQDQPPTDQQSASI Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 SPAISSSKAHSTSSVSPYYSEKNESQALNADGTAFANPSFHSFGLPQEDSQDNTQTYSTP So_F2 VPVEYPSNTSDPS--SAFYSRYFQSLQGNVSSELKDTKKMNSPPPPNSGEFNDPCNLYVS Cn_F2 QWNHNHDTSTSHRDQDPVYQDYDKQNVGYTPMQGQGMLDLMGIPQPMFFPGIQTEFNNGR Sj_F2 PNTVNSETQNVARPQDENSNWNMEVAYDRLETRSPLIARLNTVCPPTYMNPQAPCSTYDD Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 ------------------------------------------------------------ Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 LDTPDTHQNYDLFPNQQQ--HFSSQRYRTNASSSSSLGHPYAMNSD-------------- Lb_F2 MEATDTTN-YDLFPNSSSGASFSSNRYRTNASSSSSLGHNYGMHS--------------- Pc_F2 LDIDTHGS-YDIFS-SSSG-SLASQRYRTNASSSSSLGPNYSLGV--------------- Pp_F2 LDVPDQSA-YDIFAGSPSG-SLASQRFRSGASSSS-----YGLPT--------------- Um_F2 GHYSPTSTLSGAFSSRPGS-RPASRGLKSVASFTSSAGTGTGTGTASGSEAHATGRPRSS Ml_F2 SIQSSIAGHPDHFRSRSGSDSSSSWPNLHTPITPADMAFQNNNYS--------------- Ro_F2_a ------------------------------------------------------------ Ro_F2_b ------------------------------------------------------------ Pb_F2_a LQQPSIDLFGMPGILQDSAMTDITQANDHSRRHSVAVGELNYHSFPVKQ----------- Ro_F2_c -------SIDNLFDQHSYSFDSS--SGTNSRRHSVAVGELDYHSFDLN------------ Pb_F2_c ---PAPISVDPLATFHDFTLTQQDISGSHSRRHSVAVGELDFHSMDMFK----------- Ro_F2_d ----PLALQHEKFIQSLHPD-GSVGENEELMVVNFDQ----------------------- Pb_F2_b ISSQPQACQSFDFITSSYAYSGQSLQDVPLDIHSFPLRESPQVPSQLGS----------- Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 YTTMNPSNEMHPYPPATFENNYSVLPDHSSQPNAYSFTGSNILPTQSPS-LNQMQDYQNL So_F2 PFKIWPADNQQPFQSVYDTLPEAVQSSESDRFQDTAFHSLYNPSFLNPSHLPAYPAQQPI Cn_F2 ASVGVTGGYQNSMPPPQYQFRPALALDTTGGYLAPQPQPPSAYSELPSG----------- Sj_F2 SNITEQQRYSSGFVASSADPSLYPSQIPRVGYYVDSADPSPYADDTG------------- Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ----------------------MDPSNVPQASADASSTEGVAEAVASKYMNELTARLLST Um_F1 ----------------------MEAGESIDSAGASSAAANPPDQSSSKSGLESGEPQPAD Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 ----------NGLYSHSGFADSVPSFGSSNSNP-------------------YDMIN--- Lb_F2 ----------EGVYSHSSFSDSVPSFNGSNTNP-------------------YDMISSLP Pc_F2 ----------DPIYQQSSFSDNISSFHSSNSNP-------------------YDLIGSLS Pp_F2 ----------DNMYSQGGFPDGLPSFQGSSSSP-------------------YDMMNGIS Um_F2 SGSGVAPRPISALTRTTSMQSDIASFQAASPQPALTQSRSVQNFGQMQHPSMPGPLSSPR Ml_F2 -------------VAFKSDYDNSSQFDPTSHHHQ-----------------QQRQLSLSI Ro_F2_a ------------------------------------------------------------ Ro_F2_b ------------------------------------------------------------ Pb_F2_a -----------EPATTTTPEQWDPDL---------------------------------S Ro_F2_c -----------------------------------------------------------S Pb_F2_c -----------QEFDMSKWDADFQQLLGAAWAPP----------------PINPQPTFDS Ro_F2_d ------------SNPFPRLTQP-IDLDDLLQ----------------------------- Pb_F2_b -----------EPNQNTRYRQSDLQLHDLHTV---------------------------H Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------MPLAYS Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 QQNGSSNTTIPSFSSQHDLSQGLTHQPVPNHDEYAFSYPYELQRKPLIPAHPVPSFR-PT So_F2 SDEISDSLKSTRLSYPQPLSSNPDSLDFPNATAYAFLDSTVPSAANTYPLSAYTTYSSQL Cn_F2 -------------------------------------------------------LRTDL Sj_F2 ----------IRTPGNEAKLGMASELPQMGMNNDANSVLRQQQQQQQSHQQQLQALTNQS Cc_F1 ----------------------------------MPPA--------VAVVDGDPNSRSAT Lb_F1 ----------------------------------MP------------SPDSSPHNLLAT Pp_F1_a ------------------------------MRTILPFASDPLHLQMASVTTAGPQDHLVP Pp_F1_b ------------------------------MRTILPFASDPLHLQMASVTTAGPQDHLVP Pc_F1 -----------------------------MASIAVPSPADP----FPAPETANPQELSRP Mg_F1 ASESSTLQNEMATQTSASPP-----------TVTPSADVSAPNAVTASAPDAELDSTTAA Um_F1 TGDNTHQNRTSGFDTSEDRPSPDLTIMDGIPSLDTSNLVSFLPAATAQDKTGEHEPSLEE Pb_F1_a ---------------------------------------------MNSSTHVLSEEVFGS Pb_F1_b ---------------------------------------------MEHS-HVISGQVFGS Ro_F1_a ------------------------------------------------------------ Ro_F1_b -----------------------------------------MNEEEPVESHIRSEQIFGS Ro_F1_c -----------------------------------------MN-RDVLESRIMSEQIFGS So_F1 -------------------------------MTDFDGW---NVKDS-ENDPFSLDSTKIE Sc_F1 -------------------------------MAGFGSW---NIPESNENDSLTLDNLKIE Sp_F1 -------------------------------MGDYFAWDFANISGSNTSGSLNLNQLNLD Sj_F1 -------------------------------MGLHSST---RYDRASPESSMQLFSLYAA Cc_F2 -TYSSGKVSPLTPSDPVGGLHHGP-------------------FPPSVPSKDFSPSTYQD Lb_F2 SSYSSDKISPLTPSDSVSGLHHSP-------------------AYPSG--KDYPTPGYGD Pc_F2 SSYSSGKPSPITPSD-VSALPHSSG-----------------FPFSNGQSKDFPPHHSYH Pp_F2 SSYSSGKPSPLTPNDGMGGFQAPSG-----------------FSFSNGQAKDFHPHAPFQ Um_F2 PPAAAGGTEPWSPAHSHMAQSHSFRGPYSGPGFQTPQMQQFSPTLTSPAQSQYSPHTHFG Ml_F2 QEAENSQGNGTSPRQGIYELPSSQT------------DALEQYNNSNSIFGHLATPTNPR Ro_F2_a VYSSDSVPSSWSSFN----------------------------DYQMLNHSETPTSFFSS Ro_F2_b --EVESIPSSWSS-----------------------------------NSSLPHVSLFSP Pb_F2_a QLFGSSLPSSWSSSSSQGTHRERPNSVHR-------RTLTLIPDVARITPGPSTPVFFPP Ro_F2_c LLEERPLHKRAMSLREDDLTANLFSS-----------------YLFDLVDTRPRELSMDS Pb_F2_c PALERGIPRRALSLS---LSLSNHQS-----------------FLQSLQDDPPQ---MST Ro_F2_d ---QRQAFQTWDASSS-------------------------SPIQSPTRYSPGTPGFFTP Pb_F2_b RRNQQQLIQSWVGATYSAPQQVSPNH---------------SPAGSNPAFSPVTPAFFSP Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M -----------------------------------------MKSYSQFNLNAAAPPAIAY Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M THDNFYESPKTPQPTWDHVHAQFPLGEPARNLDKFIVPEAMFQSVSPLAGVAAAPSQIAA Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 SALKVNMNSNVPSSDSVRNSSPNQYYASTSKQSIPSQSQNLQPPQKASVLGTVNNYRQYQ So_F2 PELSTPHDFTYPSSAYADQSMSPLQTPSISLANTSS--TNMNSPAIDGIPRTTHKLSSNA Cn_F2 GSNTDGDLVTPNSYSSAGVQYPPYNSDFMTSLSVNTGMVNPGQSGRGIEQPQPMLGTYQP Sj_F2 AFNHMGWDVAGHFLPGDSGRFPAVTDAFSSQFVPLQHPQHDTNPYHGLPNAGAYPEVYPA Cc_F1 PNVAQSVTNKRSLQPDI-NPKRSP------------------------------------ Lb_F1 -------------------AKNTP------------------------------------ Pp_F1_a PIHQDLSRSATPQQPDL-SLLVSN------------------------------------ Pp_F1_b PIHQDLSRSATPQQPDL-SLLVSN------------------------------------ Pc_F1 SSSAQPTFDSLVHTPASSHPDDVQ------------------------------------ Mg_F1 SLEKFMSTLKEHLQLDTDTWDMSG------------------------------------ Um_F1 QIQAFTAGLANQLRPSSAEPQHTPRQDSIVNSPYDTPTQANGTPATAEDIASFETLIASL Pb_F1_a SKKIQFVQTTSSMDSLLSAVDRAP------------------------------------ Pb_F1_b SRKIQFIG-ISPIDSHLNTAMHLP------------------------------------ Ro_F1_a ---------MTPMESLLNAIDKVE------------------------------------ Ro_F1_b SRKIQFIG---------LSKPPLP------------------------------------ Ro_F1_c SRKIQFIG---------LSKPPLA------------------------------------ So_F1 KLKNELILRGDFDLDQN-NNQAVNS----------------------------------- Sc_F1 NLKNELILRGDLNLDQN-NDQNVNT----------------------------------- Sp_F1 NINNGLHNQEDGAGGRNENSERVGSGS--------------------------------- Sj_F1 -VNSALSSLERKDRQTN------------------------------------------- Cc_F2 MGDRRLG-MNGNGYQNDYQDDYSINGMNNGL---AFPQS-MPQFPDRLG----------- Lb_F2 MSERRLPNGSSTGYQSEYSDEYGIGGVNNGL---SFPPSTIQHFQDRLG----------- Pc_F2 EPMLDRRISNASGYSNDFNDEFGSMGVNHGLGLNGFPPSGLPPFPDRLG----------- Pp_F2 D--VDRRPG---SYQSEFSDDYGGM---TGMPIG-FSPSQLQSFQDPIS----------- Um_F2 SNSSGMIPFFSPSMDTMQHFQASTGHPAESFDIAGFSEQRLSSALANSASISGAPPSATT Ml_F2 HQVLNRRMSNDPSVDDGLSSNRHESPLSLDIPSAPLSGQRSRSPSALRGS---------- Ro_F2_a NLLDTLK----------QEDDFMH--LNTSRTVHPL------------------------ Ro_F2_b SFLETLK----------LEDE------NDFNTIHPS------------------------ Pb_F2_a NFLDALN----------SEEEEHDTFQDTFQDTFPLNL---------------------- Ro_F2_c SIISDLS----------LNDLSNN-NPD-LYKFNTSLE---------------------- Pb_F2_c KEIMMLP----------FMDPSCL-SPDDFLSLQPLQD---------------------- Ro_F2_d GFLESLQ-------EHPVYDHSLS------IDYGSHHFNQEYN----------------- Pb_F2_b SFLDSLQGDGHSSPRQLTLDQSYSQPVSTGLDTRPLDWNSDYNSTQADQRLNMVAQTRDM Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ET---------------------------------------------------------- Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M LQ---------------------------------------------------------- Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 NSFISLNDYQAAQSNISSPSSRFPTPYSPSVPFGTYQEKE-------------------- So_F2 TNKHHFQQSLATHPSIESESQHLFAPN--------FYESS-------------------- Cn_F2 TVMPQYGYYSIPHPEMQQAQQPVEPSVQLGTISPSELGQR-------------------- Sj_F2 DPTSSYSGPFTDQQGNFGSSFGDVVPGGNPTSS--------------------------- Cc_F1 ----------------------------------------------TPQVGGAPSPVVAQ Lb_F1 ----------------------------------------------STSTQAPPPPITAA Pp_F1_a ----------------------------------------------HHASLANGQPAGSP Pp_F1_b ----------------------------------------------HHASLTNGQHADSP Pc_F1 ----------------------------------------------TADTTANRRPSSPT Mg_F1 ---------------------------------------------SAEDVFSSSLPAMLD Um_F1 MPTPQ---------------------------------PGSPAPPPTQDVLAQSASQSIP Pb_F1_a --------------------------------------------RINLPYTQ-------S Pb_F1_b --------------------------------------------SPHPLRTQPASHQYTS Ro_F1_a --------------------------------------------PITKKRKL-------- Ro_F1_b --------------------------------------------PQQQQKDQ-------- Ro_F1_c --------------------------------------------PAQQQKDQ-------- So_F1 ---------------------------------------EAVPIQVLSLFSAVNSALTNV Sc_F1 ---------------------------------------EAMPIQVLSLFSAVNSALTNV Sp_F1 --------------------------------------PGSVSMQVLSLFSAVNSALATL Sj_F1 --------------------------------------------AIQAFPESVSEASTDS Cc_F2 ------------------------------------------------RYPND-RFS-HP Lb_F2 ------------------------------------------------RFPPD-RYN-HA Pc_F2 ------------------------------------------------RVQNESRYPNST Pp_F2 ------------------------------------------------RMQASGRYP-SI Um_F2 HQREGHSTPTIVEEEEDVPQRQTRATVLRTAHTDVRIEPGFQSHPAAHQLQHHHPNLQQL Ml_F2 ---------------------------------------------SNQHLQAPMSAGASY Ro_F2_a ---------------------------------------------------TIPDNNNHS Ro_F2_b ---------------------------------------------------VIY---HHS Pb_F2_a ---------------------------------------------------NIDPLGLYD Ro_F2_c ---------------------------------------------------TITPSATLT Pb_F2_c ---------------------------------------------------STISPSILA Ro_F2_d --------------------------------------------------PLLVKLEEQS Pb_F2_b LSPPASPPHS----------------------------SNSSTNSSPPITPMYGRLSNLS Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------TVVNPN Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------QIQALM Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 --------------------------------------------KSYSQDHAELSYYQQS So_F2 --------------------------------------------SLFYQPYTDQP--HQD Cn_F2 ----------------------------------------------QPLKPTKSFSDLMM Sj_F2 --------------------------------------------NSPAVLELSGHSPTHL Cc_F1 DPNLSIQSILAASKK------------------------------------DGPTNG--- Lb_F1 DPNASIHSILTASKK------------------------------------DPPANSQPW Pp_F1_a STDQTIQSILEVAKH------------------------------------VSAPSNGPP Pp_F1_b STDQTIQSILEVAKH------------------------------------VSAPSNGPP Pc_F1 QPAQTIQSILTATTEP-------------------------------DTSCAAPPAQPAW Mg_F1 DPSAALASTSTGAAP----------------------FAHTSGFPLDRSSTLTDASASAA Um_F1 DAATQTASITSESEPSSTSADSAAQNFVDKLLREANLFPQESVNQQQHEFTISNGVQDAS Pb_F1_a KQTMSIEALLDTNGHI------------------------------------SKSSAKRS Pb_F1_b HQTMSIESLLDSNGET------------------------------------P------- Ro_F1_a --SMSIESMIEKR----------------------------------------------- Ro_F1_b ---MSIESLLTFS----------------------------------------------- Ro_F1_c ---MSIESLLTFS----------------------------------------------- So_F1 EKTETDSSHIQAKLE------------------------------------DDP----KS Sc_F1 EKTETGSRHVQAKLE------------------------------------DDP----KG Sp_F1 EKSEEFPSVVKDEQS------------------------------------IFPAVAKAS Sj_F1 ELQRQQQ---QVPQS------------------------------------VPP------ Cc_F2 QGQQQVQSHISPAQSTDMMRGIPP--HATHSFD-RDPSAGYDSM-HYMNPNPHQDMSLRM Lb_F2 SG-----PTIPSHHGPDILRSVAP--HATHSFR-EGGVAGYDEMPHYIGASPHQDVALRM Pc_F2 VPPLTATSHLTQSHSPELIRGVAP--QATH-------LPSFDDMNFMGASPTVYDPPLRL Pp_F2 VSPLSVPPHVHQSSGPDMLRGVNP--HATHGFRSEGGVPSYDDMPQFLAPNPQVDFPLRI Um_F2 QHPHSMRQHQPPHPLPQLLPGHLP--PALHRSHSDQLSGLCMDAPPTFRNQMSYPPHMRP Ml_F2 SRSTSIDSTYTRARSSSLALGHSSDEGGMSQAFNTAWSASAQQLPAQIGSQFAGLHIEGG Ro_F2_a PTRNIISS------------------------PLNNNYDNTSLFHAIFKEDEKDK----- Ro_F2_b PQTTTISS------------------------PDHSN---------LFNLQENKI----- Pb_F2_a PISSYIPQT---------------------FVPTDVDEMTHWVLNASIKQEALTPPPMQS Ro_F2_c NEINSMAD--------------------WLLENPQKRPRRSTDSP--LGSSSDS----SS Pb_F2_c DDTNSTTTTTTTT------------TDISFTENNIKRPRRTVVVPPTLASPPNSPFSLSP Ro_F2_d PEKNLVSQSG---------------ESVTSLFPSDPAS----IVRPNQAHDSPIRRSSS- Pb_F2_b IRSTPVSVSVSAPGQIPFNGHHYYDNSATTTIPTNMTGGHPMLVVATAAHPPTIPEAASE Mm_M ---------------------MPSGFPQSPRTSPRARPKTRITGALPMDYSEGLSAEERP Hs_M -----------------------------------------------------MAWIKR- Xl_M ---------------------MQPGIPKYTPS------------------AIQLAPVVTG Dr_M -----------------------------------------------------MAPVVTG Dm_M GSPLDPHQQQQQQSQDMPHFGLPGPQPPSSQQQQQQLQVHHQQQQQQQQQQQQQQHQQQM Hr_M ---------MYHLNVTPDKQTSPHGCLVVSETDQQRSHVKER-VNGTPNQNGGTSTSSKP Ci_M ---------MYHPHHLP-----AHGQVQSHQHREDAAATSSRDVNGGLSVT--ESAIASF Ce_M TFQMQQNNLFPKIDTISKSPTPELASPSAKRMRLSPSTSSHSDVASTSKGTNGQDQSKNS Mm_ML ----------------------------MDPRETTDPSLPPGPLTHLSLPDSSEVRLQSD Hs_ML ----------------------------MDPAGAADPSVPPNPLTHLSLQDRSEMQLQSE Dr_ML ----------------------------MQDQRKEDRD------TGLSIVDSTDSHLYTP Sp_F2 PSMMPPYDRSSVYFQQP----LSRTDVPNQSFQQYPTTVDGGSMIPNLYPTSAEQMGLYP So_F2 TSCLPPSLHSNAYCHKPPKHAQYRATHPDSIISTRPLTSDAYAFQ------NGEPISIKK Cn_F2 GSRASSSSSLASQDVPDGWNGNALEDWTRPLSRALPSSGTPVSQSAGSRQLPAAADVSAL Sj_F2 YGAGDAPRLQQLHQQPRQQFHVSDYGQFHVPAGTNNPNANNGFRVPFGGSSPGPELSQTS Cc_F1 TSQATWHPPPPPATST-------------------------------------------- Lb_F1 ASNSSLPVAPAVQSQS-------------------------------------------- Pp_F1_a IPWNSLPPPPPPENSS-------------------------------------------- Pp_F1_b ITWNNLPPPPPPENSS-------------------------------------------- Pc_F1 NPTANVGHPPRETHSA-------------------------------------------- Mg_F1 DANASADPEPIPLSVS-------------------------------------------- Um_F1 IPTATTETEPKASSVGDDALTASLEQFMASLQARVSSSLATEAATDTDAAKAKQAEESTV Pb_F1_a WTYDITDRSPKTKIHR-------------------------------------------- Pb_F1_b --------APRQPVKR-------------------------------------------- Ro_F1_a ------------------------------------------------------------ Ro_F1_b --------HPRQSQTA-------------------------------------------- Ro_F1_c --------HPRQSQTA-------------------------------------------- So_F1 RVFDSHSGVPVNRGS--------------------------------------------- Sc_F1 HFFNSLSHIQMNEQS--------------------------------------------- Sp_F1 NSLDELAQNIIPAPSP-------------------------------------------- Sj_F1 AVLFSPSSIPENPKK--------------------------------------------- Cc_F2 STAVDETLARMKLQAPPIG----------------------------------------- Lb_F2 P-SVDETLARMKLQGHPIMG---------------------------------------- Pc_F2 PASVNDDMARLRLQG--------------------------------------------- Pp_F2 PGMRMPQTS----AS--------------------------------------------- Um_F2 SLYQQVSMAEMDQLRQIHGLGVT------------------------------------- Ml_F2 NSYGVQSLEGLGMGPGEIAYNHQPGG---------------------------------- Ro_F2_a -----------NLNHTCI------------------------------------------ Ro_F2_b -----------YSNHQQK------------------------------------------ Pb_F2_a SPSTSPSPPIPSLQSMSY------------------------------------------ Ro_F2_c SP-PITPMQQVSLGFEPI------------------------------------------ Pb_F2_c SPSPPTPLQANSM-FEPIRCTAE------------------------------------- Ro_F2_d -------HTTASSPHR------L------------------------------------- Pb_F2_b EDETRLTSGPISSPHRNHPNVII------------------------------------- Mm_M AHAPSAGKFGERPPP--------------------------------------------- Hs_M -------KFGERPPP--------------------------------------------- Xl_M -------KFGERPQP--------------------------------------------- Dr_M -------KFGELPQP--------------------------------------------- Dm_M QMSLLPGPYRPHIEE--------------------------------------------- Hr_M R------SVFENRPP--------------------------------------------- Ci_M R------SLREKYPP--------------------------------------------- Ce_M PTNSDPFYTIGQSTPNTSSFLDTSNSSFGAPSTVVANPMTNYQLAF-------------- Mm_ML GP--SLLGSWTRSPP--------------------------------------------- Hs_ML ADRRSLPGTWTRSSP--------------------------------------------- Dr_ML DACFTHLRE-DQSFS--------------------------------------------- Sp_F2 QDSQNKDTYPKSLVNRPSS----------------------------------------- So_F2 SKSMTEDSVPINTTSESAS----------------------------------------- Cn_F2 PDLTKRPSFASSPLRNPS------------------------------------------ Sj_F2 FYDGPEFPAPAESSHASLLR---------------------------------------- Cc_F1 --------STG----------KRKLDETESEDTHSKIRRIVRDHVSQDPARVVP------ Lb_F1 --------SAG----------KRKLDESESEDPHSKIRRIVRDHVSQDPSRVMP------ Pp_F1_a --------GPGPSTQSQRANVKRRLEDSDAENPHNKIRRVVQDHVSHDPARVMP------ Pp_F1_b --------GPGPSTQSQRANVKRRLEESDVENPHNKIRRVVQDHVSHDPARVMP------ Pc_F1 --------LPGPPPAPPRTSTKRKLDASEADDPHTKIRRVVRDHVSQHTPRPIP------ Mg_F1 VPVPVPVSPPSIPPVPR-----ERVHSLSPAEHRQKIAQLVREHMHEEAHGLTKLG---- Um_F1 KSKPSPQKQPKVVKKPKKVLGKRKYREIGPMERRSRVEKALSEYIASIDTLTKPNS---- Pb_F1_a ----------------------SQLETHSPPTEHCPEPIQHLSLSSSLLLPPQR------ Pb_F1_b ----------------------PLSQPCVPPSTKIRR------------LPPP------- Ro_F1_a -------------------------QLNSPP------------------LSPKQ------ Ro_F1_b ----------------------STNDITINNLLTCDMKRKWAEPSLSVRKKLKK------ Ro_F1_c ----------------------STNDITIDNLLTCDVK----EP---TRKRAKK------ So_F1 ---------------------RKRKNIE-ELVSRDSTQDLISKNLNLLYRYKLDKR--VD Sc_F1 ---------------------RKRKNMEDENVSENSINDLISKNIELLCQNNLNQG--AD Sp_F1 -----------------PGFNRKRKTFD-EDSSVEMIRRAISDHLDLLNNCCIGIANLNE Sj_F1 ---------------------RKASFSNHQDPLIAQIRETIFDHLNLLLKKGSATSNALC Cc_F2 ----------------------------TSSDLQTFIRPFLEQYVRTPN----------- Lb_F2 ----------------------------TSNDLHTFIRPFLDQYVRTPN----------- Pc_F2 -----------------------------SGDLQTFIRPYLDQYIRTPN----------- Pp_F2 -----------------------------ATDLQTFIRPYLDQYVRSGN----------- Um_F2 --------------------------ERNFGDCSAFIQDYVRQYISTSS----------- Ml_F2 --------------------------HHQYTTHQTQLMAYPEHSISRAERE--------- Ro_F2_a ------------------------------NQIGEDMKCSVHRYLITKQ----------- Ro_F2_b ------------------------------NLI--------QHYLSTKQ----------- Pb_F2_a ------------------------------AQQSDSLKSSIQHYLLQNS----------- Ro_F2_c -------------------------------QEEWDLQPLIQNYLLQKQS---------- Pb_F2_c -----------------------------LSQSPTSFKPLLQQYLVSRN----------- Ro_F2_d -----------------------------VHLSPLKIKPFIQTYLAHAIT---------- Pb_F2_b -----------------------------DRRSVKTNRQMIQAFQAATFRPHIQKYL--- Mm_M -------------------------------------KRLTREAMRNYLK---------- Hs_M -------------------------------------KRLTREAMRNYLK---------- Xl_M -------------------------------------KRLTREAMRNYLK---------- Dr_M -------------------------------------KRLTREAMRNYLK---------- Dm_M -------------------------------------KKLTRDAMEKYMR---------- Hr_M -------------------------------------QRLTREAMSKYLR---------- Ci_M -------------------------------------KKLTRDAMRRYLK---------- Ce_M ----------------------QAKLGSLHSLIGDSVQSLTSDRMIDFLSN--------- Mm_ML -----------------------------------EHAIILREGVRTCLQ---------- Hs_ML -----------------------------------EHTTILRGGVRRCLQ---------- Dr_ML -----------------------------------SLLKVTRDSVRQYLQ---------- Sp_F2 -------------------AVCEPARNDSIPMMVYSQPVTIEQRIQYVLSN--------- So_F2 -------------------CLIPPS--------LYSYHTYIEERLRYVLQH--------- Cn_F2 --------------------------FSPLSPSASDTDSIIKQYIRAPNR---------- Sj_F2 --------------------------PSTSHSDSMGLNAPDRNNLFQRVKNVLR------ Cc_F1 ----------------MTTVICLHAAVAQKSYGSEKRFLCPPPIVHIEG---PVWH---- Lb_F1 ----------------MTTVICLHAAVAQKSYGSEKRFLCPPPVVHIEG---PVWH---- Pp_F1_a ----------------MTTVICLHAAVAQKSYGTEKRFLCPPPVVHIEG---PVWN---- Pp_F1_b ----------------MTTVICLHAAVAQKSYGTEKRFLCPPPVVHIEG---PVWN---- Pc_F1 ----------------MTTVLCLHAAVAQKSYGTEKRFLCPPPIVHIEG---PVWN---- Mg_F1 --TG-------STAPLMTKIKCLHASVAQKSYGSEKRFLCPPPVVHVQG---TLR----- Um_F1 --VTGPIPAADPSKTKMTTIRCSHASVAQKSYGSEKRFFNPPPIISITG---PLRRYAEH Pb_F1_a ----------------LSTITCLHAAVAQKSYGSEKRFLCPPPVVTLKSTTPG------- Pb_F1_b ----------------TTTITCLHASVAQKSYGSEKRFLCPPPVVNINSSSHI------- Ro_F1_a ----------------PNKVTCYHASIAQKSYGTEKRFLCPPPIVISQS----------- Ro_F1_b ----------------KSKVVCYYGAVAQKSYGSEKRFLCPPPIVQLKG----------- Ro_F1_c ----------------TSKMTCYYGAVAQKSYGSEKRFLCPPPLVQVHH----------- So_F1 IRLNEVNKNVNNGGSQYIKITCRHASVIQKSYGSEKRFLCPPPILMIDGPFQSLLG---- Sc_F1 LWLNDASKGMKDGRSQMIKISCRHASVIQKSYGSEKRFLCPPPVLMIDGPFQSLLG---- Sp_F1 DSVHKISLTRSGKPSQLVTVSCRHSSVIQKSYGSEKRYLCPPPMVYINGNYSSIFN---- Sj_F1 NRIRDP-LNQYNQANKLVTISYQHASVAQKSYGAEKRYLCPPPLISITGNTGSILG---- Cc_F2 -----------RLAFGERTIIVMSSKVAQKSYGTEKRFLCPPPTAIMIGN-SWWSESTR- Lb_F2 -----------RLAFGERTIIVMSSKVAQKSYGTEKRFLCPPPTAIMIGN-SWWTDVVR- Pc_F2 -----------RLAFGERTVIVMSSKVAQKSYGTEKRFLCPPPTAIMIGN-SWWSDVHR- Pp_F2 -----------RLAFGERTVIVMSSKVAQKSYGTEKRFLCPPPTAIMIGN-SWWSDVVR- Um_F2 -----------RLGLGERNVLIMTTRVAQKSYGAEKRFLCPPPLVILIGS-SWWNVCPAS Ml_F2 --------ALLAFLLGERTVLVLSGKVAQKSYGAEKRFLCPPPSALLLGC-SWWSAAEAD Ro_F2_a -------------DE--RKITILTSKVAQKSYGSEKRFLCPPPYIILSGSNNWWSTQN-- Ro_F2_b -------------GE--KKLTILTSKVAQKSYGNEKRFLCPPPSTILSGTGHWWTAKQ-- Pb_F2_a -------------PENCYTAMLLTSKVAQKSYGTEKRFLCPPPSTILQGP-NWWTHNCKA Ro_F2_c --------REDYIPG-ERTIMILTSKVAQKSYGTEKRFLCPPPATIMKGT-NWWTSDKLT Pb_F2_c ---------QGLVPTNERTVMILTSKVAQKSYGTEKRFLCPPPTTLLTGA-DWWSHEQQA Ro_F2_d --------QPAATQLGEKTVIVLTSKVAQKSYGTEKRFLCPPPTAILVGT-SWWTTK--E Pb_F2_b -------RSPDPMSVGERTVVILTSKVAQKSYGTEKRFLCPPPTAILVGT-TWWTPKKDA Mm_M -------------ERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS-GWKKKKE-- Hs_M -------------ERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS-GWKKKKE-- Xl_M -------------ERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGS-GWKKKKE-- Dr_M -------------ERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGC-GWKKKKE-- Dm_M -------------ERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIYLFGS-GWRRRYE-- Hr_M -------------ERNDQTLIILHAKVAQKSYGNEKRFLCPPPCLYLMES-GWKQKQQ-- Ci_M -------------DPNDQTLIVLHAKVAQKSYGNEKRFFCPPPCMYLLGN-GWKRKQQ-- Ce_M ------------KEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYLIGQ-GWKLKKDRV Mm_ML -------------QRCEQTVWILHAKVAQKSYGNEKRFFCPPPCVYLAGP-GWRVKPM-- Hs_ML -------------QQCEQTVRILHAKVAQKSYGNEKRFFCPPPCVYLSGP-GWRVKPG-- Dr_ML -------------FRPDQSVTILHAKVAQKSYGNEKRFFCPPPCVYLSGH-GWKVRQE-- Sp_F2 -------------CHCLSAFYLCMPSLCQKSYGTERRYLCPPIVLYLLGTTWLNNVTDN- So_F2 -------------HETLCSFNICMPSVCQKSYGNERRYLCPPIVLYFLGVNWFNYESDE- Cn_F2 ------------LAFGERKIIVMSPKVGQKSYGTEKRFLVPHPKAILIGSGWWAKSPDG- Sj_F2 ------------HPELLCAMKVFMPSLGQKSYGKERRYICPPAVVYLLGSSWFRCPLDKI : ***** *:*:: * Cc_F1 -----------------------------------------------LRTQSLSMAVVSE Lb_F1 -----------------------------------------------MRTQQLAMAVVSE Pp_F1_a -----------------------------------------------MKNQQLAMAVLTE Pp_F1_b -----------------------------------------------MKNQQLAMAVLTE Pc_F1 -----------------------------------------------MKNQQFSMTVVSE Mg_F1 ---------------------------------------------HAPSAPMLLMQVQGE Um_F1 GAATLLTPLSSED--------------------------------PEEDQCRVSLVVRGD Pb_F1_a ---------------------------------------------LRTDSPIVSMSVVC- Pb_F1_b ---------------------------------------------GQHNKPQVSLAVVC- Ro_F1_a -----------------------------------------------QTNCMISMTIMN- Ro_F1_b ----------------------------------------------ANKEMELSMSILC- Ro_F1_c ----------------------------------------------STRNLLLSMSILC- So_F1 ------------------------------------------------ISFRVEISIINE Sc_F1 ------------------------------------------------LSFRVEISIMNE Sp_F1 ------------------------------------------------QSFRTEISIMND Sj_F1 ------------------------------------------------HSFSVQLAITNE Cc_F2 --------------------RGEEPKLAPPRVVVSISGE--------PAPQECSIEWTSS Lb_F2 --------------------RGEDPKLYPPRVVISISGE--------PVPQEGSIEWTGS Pc_F2 --------------------RGEEPKLCPPRVVVSISGE--------PAPQEGSIEWTSA Pp_F2 --------------------RGEEPKLCPPRVVVSISGE--------PAPQESSIEWTGA Um_F2 TRPSPFAPAGAA-----DPDQAAPTVLSPPRVTINISGE--------PGVQDGALEWASS Ml_F2 PR---------------RPIGNHRVALVPPTTIISMSGEQ-------SMPSEAYSEWMSM Ro_F2_a ---------------------------NPPNVHIQLSGE--------QPRPYCHIDWYKE Ro_F2_b ---------------------------HPPNLTIQISGE--------KLSHQGTIDWYKD Pb_F2_a PADSR--------------------VPSPPRLTVHVSGE--------AASQTGILDWYSS Ro_F2_c DKKTPSLFHSPS------------NALQSPKLTIHISGE--------TIQQTGVIEWQTS Pb_F2_c SRATP------------------------AKLTIQISGE--------ATSQTGVLEWHNQ Ro_F2_d KIQD---KEETLRIPS----LEKDILLAPPKLTVSISGE--------TSTQAGQLEWYTV Pb_F2_b TLDDGHVSDDAQSQPPDPFLIDNERVLAPPRLTVCISGE--------ASSQAGHIEWYTV Mm_M ------------------------------QMERDGCSE-------QESQPCAFIGIGNS Hs_M ------------------------------QMERDGCSE-------QESQPCAFIGIGNS Xl_M ------------------------------QMERDGCSE-------QESQPCAFIGIGNS Dr_M ------------------------------QMEREGCSE-------QESQPCAFIGIGNS Dm_M ------------------------------EMLQQGEGE-------QGAQLCAFIGIGSS Hr_M ------------------------------ILEEADQAP-------EAGQVHAFIGIGSS Ci_M ------------------------------ILEEEEGSS-------EAGQLHAFIGIGSS Ce_M AQLYK---------------------TLKASAQKDAAIENDPIHEQQATELVAYIGIGSD Mm_ML ------------------------------QDQALQSAE-------TGPTVCGYMGLDGA Hs_ML ------------------------------QDQAHQAGE-------TGPTVCGYMGLDSA Dr_ML ------------------------------QFKASGLNE-------SACRIFGYMGLDSS Sp_F2 -----------------------------LKISAQTLEDK------DNPKFAKNIFYYNA So_F2 -----------------------------MVIMSNIVKDA------EDENLSKSILYYNT Cn_F2 -----------------------------CPVSPLQPPRINISLTGEQAVKDSIISWTDL Sj_F2 N------------------------------IIANAADDPD--NLKTSETPTFYTSSSDS Cc_F1 TGE-RSFEQKATLD---------------------------------------------- Lb_F1 SGE-RSFEQKAPLD---------------------------------------------- Pp_F1_a AGE-RSFEQKAPLD---------------------------------------------- Pp_F1_b AGE-RSFEQKAPLD---------------------------------------------- Pc_F1 GGE-RSFEQRAPID---------------------------------------------- Mg_F1 DGDSFSGEQMTSLD---------------------------------------------- Um_F1 TDEYFSNENVAVLD---------------------------------------------- Pb_F1_a ESIDRPVEQRASLD---------------------------------------------- Pb_F1_b ENGDKPLEQHAMLD---------------------------------------------- Ro_F1_a ENNQAILEQRTLLD---------------------------------------------- Ro_F1_b EDND-ILEQHTALD---------------------------------------------- Ro_F1_c EDQG-LLEQRAILD---------------------------------------------- So_F1 EGQ-YSQTVGEVYN---------------------------------------------- Sc_F1 EGQ-YSQAISEIYN---------------------------------------------- Sp_F1 FGQ-CSQPISEEYT---------------------------------------------- Sj_F1 QGQ-HSNQVSENFA---------------------------------------------- Cc_F2 SGKSFDVTDPP------------------------------------------------- Lb_F2 SGKSFDVGDPP------------------------------------------------- Pc_F2 TGKAFDVSDPP------------------------------------------------- Pp_F2 TGKAFDVSDPP------------------------------------------------- Um_F2 SGRLIDVGNPS------------------------------------------------- Ml_F2 SGHVVGDQASL------------------------------------------------- Ro_F2_a -GTLINQH-LAATYAS-------------------------------------------- Ro_F2_b -GNLLDQP-SAVLLAN-------------------------------------------- Pb_F2_a -GTMLDAEGAGAAIAA-------------------------------------------- Ro_F2_c SGNIIDNNA--------------------------------------------------- Pb_F2_c QGALLDSAASMAATACV------------------------------------------- Ro_F2_d SGATVGQTGQIKPPIKPESTS-----------------------RFRSSESRHPPADAYS Pb_F2_b SGVTVGQTGHVKAAQPSSSSSSSSPSGNGTTSGTSAQQEGLHPNRFRSAESRNNNFDWYH Mm_M D---QEMQQLNLEG---------------------------------------------- Hs_M D---QEMQQLNLEG---------------------------------------------- Xl_M E---QEMQQLNLEG---------------------------------------------- Dr_M E---QEMQQLNLEG---------------------------------------------- Dm_M D---QDMQQLDLNG---------------------------------------------- Hr_M D---QEMQQLNLDG---------------------------------------------- Ci_M E---QEMQQLHLDG---------------------------------------------- Ce_M T---SERQQLDFSTGKVRHPG--------------------------------------- Mm_ML SGSAPETQKLNFEE---------------------------------------------- Hs_ML SGSATETQKLNFEQ---------------------------------------------- Dr_ML NDPRTDSFKLSFEE---------------------------------------------- Sp_F2 DGALISPETDIAKSTYQL------------------------------------TNYNEN So_F2 DGKEISFYSEKRAS----------------------------------------ANHEQC Cn_F2 NGKNMDEKASTQGVKID------------------------------------------- Sj_F2 ATNLLSLGQVKLDDPLEQ------------------------------------------ Cc_F1 -------NNMVSSFKFLHVTGTA-KAKSFQLSLDIAEPPPPSLNPEGSETSAN------- Lb_F1 -------NNMTASFKFLHVTGTA-KAKSFQLSLDIAEPPPPALNLEGSDPPS-------- Pp_F1_a -------QSLTASFKFLHVSGTA-KTKSFQLSLDIAEPP--ATSADGSETGN-------- Pp_F1_b -------QSLTASFKFLHVSGTA-KTKSFQLSLDIAEPP--ATSADGSESDN-------- Pc_F1 -------HNLSASFKFLHVTGSA-KSKSFQLSLNITEPS--PPTADGSEPTVPG------ Mg_F1 -------DSGHARFTELHVTGTG-KAKSFRLQLHLLAPR------DDAAPIKRMRLGLGL Um_F1 -------GRLETKMRSLYVTPTG-RSKSFRLQLNLLRPSGLEPHLPIFSPLKKSRAADAL Pb_F1_a -------DNQSGSFKYLHVTGTA-KAKQFCLRVGLS---------------HSHSHSHSQ Pb_F1_b -------ENLSGSFKYLHVTGTA-KAKQFCLRVSLANQNETENDTSTTVTTNAESTTKSS Ro_F1_a -------DESKGYFKYLYVTSSA-KSKQFRIKLNMN------------------------ Ro_F1_b -------EHHSGSFRYLHVTGTA-KAKQFKLQLNLLQ----------------------- Ro_F1_c -------ENQRGSFRYLHVTGTA-KAKQFKLQLNLLQP---------------------- So_F1 -------NQRCMVFRSLHVSSLA-AAKSRNLKLSIDFFSTIT------------------ Sc_F1 -------NQQCMVFRSLHVSSLA-AAKSKILRLSIDFVSTVT------------------ Sp_F1 -------GQGCMIFRSLHISSLV-AAKSKNLRLSLDMFSNVN------------------ Sj_F1 -------ERQSVAFRSLHISSSI-AAKAKSFNLNIDVISSS------------------- Cc_F2 ---SGTTYLGRCVGKQLFISDVDEKKKKVEALVKVTAPASDDEP---------------- Lb_F2 ---TGTTYIGRCVGKQLFISDVDEKKKKVEALVKITAPGSEEDS---------------- Pc_F2 ---TGTTYIGRCVGKQLFISDVDEKKKKVEALVKIMAPSADDEP---------------- Pp_F2 ---TGTTYLGRCVGKQLYISDVDEKKKKVEALVKIMAPAAEDEP---------------- Um_F2 ---SEMAISGRCIGKQLYISDVDEKRRHVEALVAISVPGSSPMD---------------- Ml_F2 ---DDVVIAGRCVGKQLHISEVDEKTKRVEALVKVIGPGFGSPE---------------- Ro_F2_a ---QGDILVGNCLSKQLHISDTDEKRKSVQAHVSIQLDQS-------------------- Ro_F2_b ---QGSNLIGNCVSKQLHVSGADEKRRKAQVQVEIRSGQG-------------------- Pb_F2_a ---DDPSMLGKCVSKHLHISDVDEKRKRVEVQVNIQLSSG-------------------- Ro_F2_c -----QKVFGRCISKQLYINDADEKRKRVEVLAKIQLGNG-------------------- Pb_F2_c -LGETQTISGKCVSKQLHINDADEKRKRVEVLVKIQLGNG-------------------- Ro_F2_d NERQELLAAGKSVSKHLYIHDADEKRKRVECLVKLQLANG-------------------- Pb_F2_b NHHQEPLAAGKNVSKHLFINDADEKRKRVECLVKIQLANG-------------------- Mm_M --------KNYCTAKTLYISDSD-KRKHFMLSVKMFYGNS-------------------- Hs_M --------KNYCTAKTLYISDSD-KRKHFMLSVKMFYGNS-------------------- Xl_M --------KNYCTAKTLYISDSD-KRKHFMLSVKMFYGNS-------------------- Dr_M --------KNFCTAKTLYISDSD-KRKHFMLSVKMFYGNS-------------------- Dm_M --------KQYCAAKTLFISDSD-KRKHFMLSVKMFYGNG-------------------- Hr_M --------KNFCTAKTLYISDTD-KRKHFMLCVKMFFGSG-------------------- Ci_M --------KNFCTAKTLYISDTD-KRKHFMLNVKMFFGGGG------------------- Ce_M DQRQDPNIYDYCAAKTLYISDSD-KRKYFDLNAQFFYGCG-------------------- Mm_ML ----QPDSREFGCAKTLYISDAD-KRKHFRLVLRLVLRGG-------------------- Hs_ML ----QPDSREFGCAKTLYISDAD-KRKHFRLVLRLVLRGG-------------------- Dr_ML ----QTDKKMFACAKTLYISDTD-KRKHFRLLLHLFHNGG-------------------- Sp_F2 TNFDSFPVWGNALLKTIYYTGQG-KNDGFGRSTFLQLSVQSK------------------ So_F2 QKLN--PVWASTMLKTIYYTGTG-EHDKLGRSMQLQLQIDTK------------------ Cn_F2 ----DQPFTGSVAGKNLHISDNDPKRKEVKALVTVKAPLNKHAGPNGWGNAKGTLSDVSN Sj_F2 -QQSPSPIWANTVLKTLYYSGKG-DHNTYGRSTTLQVHVRTP------------------ :. . Cc_F1 --------------------------GRVWATFDSAPVTIISKPSKKTAK--TRNIS--- Lb_F1 --------------------------GRVWASFDSAPVTIISKPSKKTAK--TRNIS--- Pp_F1_a --------------------------GRIWASFDSAPVTIISKPSKKTAK--TRSVS--- Pp_F1_b --------------------------GRIWASFDSAPVTIISKPSKKTAK--TRSVS--- Pc_F1 --------------------------RLPWASFDSAPVTIISKPSKKTAK--TRNIA--- Mg_F1 SDTAAVRNAS-------------------WACFDSAPIGIISKPSKRIAK--ARNVS--- Um_F1 SPAMSIGSPANEPIENGSEVLSRLPKELAWASFESAPVTIISKSSKKTAK--PRGEL--- Pb_F1_a FPPLGS-------SSPQQQQNQHHQISQPFATFFSSPVSIISKPSKKTAK--ARNVS--- Pb_F1_b LPLSSSPSA----SSASASSSSSSSSPQPFATFLSSPISIISKPSKKTAK--ARNVS--- Ro_F1_a -----------------------------DALFYSNPISIISKPSKKTAK--TRNAT--- Ro_F1_b -------------------------NESSFASFLSKPISIISKPSKKTAKT-SRNTS--- Ro_F1_c ------------------------EDESPLATFLTKPITIISKPSKKIGKT-ARGTT--- So_F1 --------------------------DQKVSHFVTSPIDVVSKPAKKGTK--SKVSH--- Sc_F1 --------------------------DQRVSHLVTSPIDVVSKPAKKGTK--SKVSH--- Sp_F1 --------------------------NQLLSHLVTSSISIVSKPSKKGSK--LKISN--- Sj_F1 --------------------------DDVLAQMVTKPINIISKPSKKGSK--NRVSN--- Cc_F2 --------------------------ERIIGVFPSRPIKVISKPSKKRQS--AKNLE--- Lb_F2 --------------------------ERVIGTFPSRPIKVISKPSKKRQS--AKNLE--- Pc_F2 --------------------------ERVIGTFPSRPIKVISKPSKKRQS--AKNLE--- Pp_F2 --------------------------ERVIGTFPSRPIKVISKPSKKRQS--AKNLE--- Um_F2 --------------------------RRLLGTFPSRPIKVISKPSKKRQS--SRNTE--- Ml_F2 --------------------------HRHIGTFPSRPIKVISKPSKKRQS--IKNLDRAM Ro_F2_a ---------------------------RSLGTFDSKPIKVISKPSKKRQS--AKDME--- Ro_F2_b ---------------------------TPIGIFHSKPIKVISKPSKKRQS--VKNMD--- Pb_F2_a ---------------------------FNLGNFCSQSIKVISKPSKKRQS--ARNME--- Ro_F2_c ---------------------------SNLGTFSSKGIKVISKPSKKRQS--AKNME--- Pb_F2_c ---------------------------LILGTLASKGIKVISKPSKKRQS--AKNMD--- Ro_F2_d ---------------------------LQLGPLASKAIKVISKPSKKRQS--IKNME--- Pb_F2_b ---------------------------LMLGTLASKGIKVISKPSKKRQS--VKNME--- Mm_M ---------------------------DDIGVFLSKRIKVISKPSKKKQS--LKNAD--- Hs_M ---------------------------DDIGVFLSKRIKVISKPSKKKQS--LKNAD--- Xl_M ---------------------------DDIGVFLSKRIKVISKPSKKKQS--LKNAD--- Dr_M ---------------------------ADIGVFLSKRIKVISKPSKKKQS--LKNAD--- Dm_M ---------------------------HDIGVFNSKRIKVISKPSKKKQS--LKNAD--- Hr_M ---------------------------LEVGAFNSRRIKVISKPSKKKQS--LKNAD--- Ci_M ---------------------------ADVGQFSSKRIKVISKPSKKKQS--LKNAD--- Ce_M ---------------------------MEIGGFVSQRIKVISKPSKKKQS--MKNTDCKY Mm_ML ---------------------------QELGTFHSRLIKVISKPSQKKQS--LKNTD--- Hs_ML ---------------------------RELGTFHSRLIKVISKPSQKKQS--LKNTD--- Dr_ML ---------------------------QEIGTFNSRLIKVISKPSQKRQS--MKNAD--- Sp_F2 ---------------------------TKYFKLENLRLGVISKPSQKRALMKVSD----- So_F2 ---------------------------NKQLGIDKVRLGVISKPSQKRALAKVSD----- Cn_F2 --------------------------DIVFGIFESKDIKIISKPSKKRST--AKSGE--- Sj_F2 ---------------------------QKRITMDKLRIGIISKPSQKKMMMKVSDLN--- : . : ::**.::: Cc_F1 ------------SCILAGGPVSLFNRINSQTVRTKYMTIDHG------------------ Lb_F1 ------------SCILAGGPVSLFNRINSQTVRTKYMTIDHA------------------ Pp_F1_a ------------SCILAGGPVSLFNRINSQTVRTKYMTVDSG------------------ Pp_F1_b ------------SCILAGGPVSLFNRINSQTVRTKYMTVDSG------------------ Pc_F1 ------------SCILAGGPVSLFNRINSQTVRTKYMTVDNG------------------ Mg_F1 ------------AHITKDASVSLFNRINSQTYRTKYLCAQDG------------------ Um_F1 ------------NQVKNGSMISLYNRINSQTARTKYMRSSNGG----------------- Pb_F1_a ------------TCILANSPVSLFNRINSQTVRTKYMSSDAN------------------ Pb_F1_b ------------TCILANAPVSLFNRINSQTVRTKYMTSDNN------------------ Ro_F1_a ------------SCLFNHSTISLFNRINSQTVRTKYMSTESN------------------ Ro_F1_b ------------TCILANSPVSLFNRINSQTVRTKYMTCDHN------------------ Ro_F1_c ------------SCISTEAPVSLFSRINSQTVRTKYMTSVGS------------------ So_F1 ------------ITLRSGSIINLYNRINSQTVRTKYTTLENG------------------ Sc_F1 ------------ITLRSGSVISLYNRINSQTVRTKYTTLENR------------------ Sp_F1 ------------ITLRSGSVVSLYNRINSQTVRTKYTSIEAG------------------ Sj_F1 ------------STLMSGAIISLYNRINSQTVRTKYMSVANG------------------ Cc_F2 ------------LCINHGSTISLFHRLRSQTVSTKYLCVSGSNSSFKGSDGAPLMGL--- Lb_F2 ------------LCINHGSTISLFHRLRSQTVSTKYLCVSGSGSSFKGSDGAPLMGL--- Pc_F2 ------------LCINHGSTISLFHRLRSQTVSTKYLCVSGSGSSFKGSDGAPLMGL--- Pp_F2 ------------LCINHGSTISLFHRLRSQTVSTKYLCVSGSGSSFKGSDGMPLMGL--- Um_F2 ------------LCVNHGSVISLFHRLRSQTVSTRYLCVSGAPSWFKGSDNQPFLNM--- Ml_F2 NISLTTFIKQPTVCIHHGTTIALFNRLRSQTVSTKYLCVSGPSASFPAGDWRAMAGI--- Ro_F2_a ------------LCIHNGSTVALFNRTRSQATSTKYLGISSQ------------TN---- Ro_F2_b ------------LCIHHGTTVALFNRVRAQTISTKYLGVSSL------------DS---- Pb_F2_a ------------LCIHHGTPISLFNRIRSQTVSTKYLGVS--------------AG---- Ro_F2_c ------------LCIHHGTTISLFNRIRSQTVSTKYLGVSTT------------T----- Pb_F2_c ------------LCIHHGTTISLFNRIRSQTVSTKYLGVSRN------------NQP--- Ro_F2_d ------------LCIHHGTTVSLFNRIRSQTVSTKYLGVSTS---KGSPLAFPGLAF--- Pb_F2_b ------------LCIHHGTTVSLFNRIRSQTVSTKYLGVSSSSA-QGSPYAFPGHAQ--- Mm_M ------------LCIASGTKVALFNRLRSQTVSTRYLHVEGG------------------ Hs_M ------------LCIASGTKVALFNRLRSQTVSTRYLHVEGG------------------ Xl_M ------------LCIASGTKVALFNRLRSQTVSTRYLHVEGG------------------ Dr_M ------------LCIASGTKVALFNRLRSQTVSTRYLHVEGG------------------ Dm_M ------------LCIASGTNVALFNRLRSQTVSTRYLHVENG------------------ Hr_M ------------LCIASGTKVALFNRLRSQTVSTRYLHVENG------------------ Ci_M ------------LCIASGTKVALFNRLRSQTVSTRYLHVEKG------------------ Ce_M ------------LCIASGTKVALFNRLRSQTVSTRYLHVEGN------------------ Mm_ML ------------LCISSGSKVSLFNRLRSQTVSTRYLSVEDG------------------ Hs_ML ------------LCISSGSKVSLFNRLRSQTVSTRYLSVEDG------------------ Dr_ML ------------LCISSGSKVSLFNRLRSQTVSTRYLAVEDG------------------ Sp_F2 ------------MSIRHGDCVCLFNRYRAQHNNALFLGTSNVQRAISKVSLNMKYNSNYF So_F2 ------------MSICHGDCVSLFNRYRAQHNNALFLSTSKMCQVLSDKSTRMKTSGNFF Cn_F2 ------------LTISHGTTVALFNRIKSQTTSTRYLSVVPDFTRTLGSDGRPVTGAKTP Sj_F2 --------------ICHGDCVSLFNRFRSHNNLPRYLCTNVLNDVVTKRTEHLQFHEEFT : : *: * .:: . : Cc_F1 --------------QLCASNIGWSAFNVNVVR-RPDG---------SPNTNG-------- Lb_F1 --------------QLCASNVAWSAFNVNVVR-RPS----------TVAAGG-------- Pp_F1_a --------------QLCASNVAWSAFNVNVVS-RPPN---------ASNDPGP------- Pp_F1_b --------------QLCASNVAWSAFNVNVVS-RPPN---------ASNDPGP------- Pc_F1 --------------QLCASNVTWAAFNVSVVRPQGDQ---------PTIVLG-------- Mg_F1 --------------RLFAQSRSWTAFRLVVLSRRDAS---------GPLDTS-------- Um_F1 --------------DLTVHNGDWSTYRITLISR-PPL---------AELAGA-------- Pb_F1_a --------------RLCAKSSAWSAFNIQIIRQPED----------------------AE Pb_F1_b --------------RLCAKNSSWSPFTITILRQPTQP---------PSPSKSGRTTGPAH Ro_F1_a --------------QLCAKHSTWSPFEIIVLRQPNK------------------------ Ro_F1_b --------------RLCAKNTTWSPFDVIVLCQPKQV---------VITKQS-----KSS Ro_F1_c --------------KLCAKHSIWSPFDILLLRQPQPT---------VLTTTK-----KTS So_F1 --------------NFCLRSDGWAPLRIHLISTSAES---------NVEGMIN------- Sc_F1 --------------QFCLRSDGWAPLRIHLISSSPES---------TTEGILN------- Sp_F1 --------------QFCLRGDRWVPLRINLLLPD-EN---------GKLKVCD------- Sj_F1 --------------RFCLRNESWTPLQIRVYGAS-------------------------- Cc_F2 --D---QRSRQSTPSFIARTASWDPFIMYIVDVNKP-------GGGLDVPPPPPPQPDYP Lb_F2 --D---QRSRSTTPSFIARTASWDPFVMYIVDVSKPA------GGGVDAPPPPPPQPDYP Pc_F2 --D---QRARTQTPSFIARTASWDPFIMYIVDVNKP-------TGGIDTPPPPPPQPEFP Pp_F2 --D---QRVRTQTPSFIARTASWDPFIMYIVDVNKP-------AGGVDSPPPPPIQPDYP Um_F2 --NPRDQKGSEPPSCFVAKMSSWDPFIIYLVDPKKR-------ADATPSEPVQPPVKGYP Ml_F2 --DEKPFSPSEESTCFVARTSCWDPFIIFLVDLKNSP------HSASAEHHGSPPPPGYP Ro_F2_a -------NQ-NPNTCFVARTTSWDPFLIWIVDPTRSP-------NTSPST--LQHAANSQ Ro_F2_b -------QQKDRGTCFVTRTTSWDPFLIYIVDLSRSP-------NTPSPVPFSHHPTIDH Pb_F2_a -------EKDVTGACFVARTGSWDPFIIWIADTTRTQ-------ETNNRP----PPDTPG Ro_F2_c ------PQPDSNGTCFVSRTGVWDPFVIWIVDTSCSP-------NTANRP--KHNPLNPN Pb_F2_c --TNGLPVADTNGTCFVARTGQWDPFVVWIVDTQHQSTE---PHNTKDQL--NQSMKNKY Ro_F2_d --QHEKN-RTSEGTCFVARTTSWDPFVIWIVDTSASSEE--EGETPEDYIGHHVFARSTP Pb_F2_b --PKTQASDVNDGTCFVARTTCWDPFVVWVVDTTRTPGDGKESDTPEDYIGRNVYTPSVP Mm_M --------------NFHASSQQWGAFYIHLLDDDE------------------------- Hs_M --------------NFHASSQQWGAFFIHLLDDDE------------------------- Xl_M --------------NFHASSQQWGAFYIHLLDDEE------------------------- Dr_M --------------NFHASSQQWGAFYIHLLDDDE------------------------- Dm_M --------------HFHASSTQWGAFTIHLLDDNE------------------------- Hr_M --------------NFHASSIQWGSFAIHLLDDDE------------------------- Ci_M --------------NFHASSIQWGCFAIHLLDDDE------------------------- Ce_M --------------AFHASSTKWGAFTIHLFDDERGL----------------------- Mm_ML --------------AFVASARQWAAFTLHLADGHC------------------------- Hs_ML --------------AFVASARQWAAFTLHLADGHS------------------------- Dr_ML --------------AFVASARQWTAFTIHMIDTQA------------------------- Sp_F2 PTTDAPNDAENEGAGLAMANNLWEPFYIFSVDELNKG----------------------- So_F2 PDIDTPTVAENEQGRLIMTSDTWEPFYILSVEELKKG----------------------- Cn_F2 ----QYADEKGALKGFTADASFWESFIIWLVDPSLPS-------------GPSNHQPPNP Sj_F2 P-ATDLDLMEASTCRLITTNTVWEPFNIYSVEELENK----------------------- : * : Cc_F1 ---------------PQPVTYGCEIVLSDTQSGISTSPLVIRKVDKGRVSPDDG------ Lb_F1 ---------------PQPVTYGCEIVLSDTHSGISTSPLVIRKVDKGRVCAEDG------ Pp_F1_a ----------LAGPGPQTVLYGSKVILSDTVTGTPTPPLFIRKVDKGRIATDDG------ Pp_F1_b ----------LAGPGPQTVLYGSKVILSDTVTGTPTPPLFIRKVDKGRIATDDG------ Pc_F1 ---------------PQPVTYGSEVILTDTLSGISTSPLTIRKVDKGRIAPDDG------ Mg_F1 --------------DVSVLTYGSVILLVDPTSGASTDPLIVCKVDRGRILPPID------ Um_F1 --------------EADSVTYGSTIVLTDVNTGFSSDPLVVCKVDKGQVQLPQLDPPSVL Pb_F1_a DN----------EDGPVPVLYGTEIILKDTQSGVCSPPLIVRKVDKGCIAATAT------ Pb_F1_b SNGTAIRSHQPSQNHAMPVTYGTEIILTDTQTGIISPPVIIRKVDRGRIAACAY------ Ro_F1_a ---------------TEAISYGTEILLKDIQTGITSPPLIIRKVEKNKVVYDAF------ Ro_F1_b PRYNTSRLQLPKTP-VSYLTYGTEIILRESRTGLSSPPLILCKVDRGRLVESAY------ Ro_F1_c KRYNTARLQFSTPASAAHLMYGSEIILRESHTGVSSAPLMVCKVDRGRIVPDAC------ So_F1 -----------NSLEAVPIRYGSVVQLQDESSQIMSDPLIIRRVEKDEIAQDDG------ Sc_F1 -----------NSVEAVPIRYGSVIQLQDEFSEIMSDPLIIRRVEKDGIAQDDG------ Sp_F1 -----------DVDNPEPIKYGSIVELVDEATGTTSDPLIIRRVEKDHIAEEDG------ Sj_F1 -----------ESSFHQPIMYGSQVVLYNERSGIVSDPLYIHRVDKDQIAPDDG------ Cc_F2 SPPPNAIPFT-NNGSQIPIYYNQTVVLQCLTSGVVSPVLIIRKVDRQTTVVGGGLQE--- Lb_F2 SPPPNAIPFT-NNGSQIPIYYNQTVVLQCLTSGVVSPVLIIRKVDRQTTVVGGGLQE--- Pc_F2 SPPPNAIPFT-NNGSQIPIYYNQTVVLQCLTSGVVSPVLIIRKVDHQTTVVGGGLQE--- Pp_F2 SPPPNAIPFT-NNGSQIPIYYNQTVVLQCLVSGVVSPVLIIRKVDHQTIVVGGGLQE--- Um_F2 PPPPNALPTTGLTSSQMTIHYNQPIVLQCLNTAVVSPVMVVRKVEKGTTVLGGASAG--- Ml_F2 RPPANALPVA-QGAGPVPIYYNQPIVLQCLSTAVVSPVMVIRKVDKGSTATGGASLDGHG Ro_F2_a YPPPPAIAVQNPK-QPLVLHYNHLIVLQCVSTGLISPVMVIRRADKGSMVMGGNRVNDPP Ro_F2_b YPPPPAIAIQNHQ-GSLALHYNQPVVLQCVSTGLVSPVLIIRRVEKGSMVMGGNRVNDLS Pb_F2_a MPPPPAIALQLQTNQPTAILYNQAIVLQCATTGLVSPVMIIRKADRGSLVQGGNRVAR-P Ro_F2_c YPPPPAIALQTSS--TLAIHYNQPVVLQCVTTGLVSPVMIIRKVDKQSLVLGGNRVDNPI Pb_F2_c SPPPPAIALKAKG-GPIAIHYNQPVVLQCVSTGLVSPVMVIRKVDRGSMALGGSRIDRSN Ro_F2_d YPPPPPIALKNKTGGPVPIHYNQHVVLQCLTTGLVSPVMIIRKVDRASTVVGGAR---DD Pb_F2_b YPPPPAIALKNKTNQLVPILYNQHIVLQCLTTGLVSPVMIIRKVDKASTVVGGARSVDDP Mm_M ------SEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDA------- Hs_M ------SEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDA------- Xl_M ------SEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDA------- Dr_M ------SEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALMDA------- Dm_M ------SESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMALLEA------- Hr_M ------SESEEFTVRDGYIHYGQTVKLVCSTTGMALPRLIIRKVDKQTAILNA------- Ci_M ------SESEEFSVVDGYIHYGQTVKLVCSNTGMALPRLIIRKVDKQTAILDA------- Ce_M ------QETDNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVDKQQVILDASCS---- Mm_ML -------SQGDFPPQEGYIRYGSLVQLVCTVTGITLPPMIIRKVAKQCALLDV------- Hs_ML -------AQGDFPPREGYVRYGSLVQLVCTVTGITLPPMIIRKVAKQCALLDV------- Dr_ML -------VHSEYTMCESYICYGCVVQLVCTDSGVALPPMVIRKVNKQQACLDV------- Sp_F2 ------NNSNPSDSRSKVLCSNMVIILVSKITGVQSPPLILKKHDNWKVSLSSRAP---- So_F2 ------NGSVAANTQRVVLSFDTLVILVSKITGVQSPPLVLKKRENWKVSISCTKS---- Cn_F2 DWPRPPANIIPLNTISHSIRYNSTVVLQSLRTGVISPTLVVRRIETDSDAVGMDGHVHEV Sj_F2 ---------SSYDRRNTVICSNMRIIIQSQITGVRSPPLIIRKYENRKALVVEDDQ---- : . : : : : : : Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 LKAGTGNKSRRVPIDPALRDKLATVSKSVSHANPSTSLGAGASTSNHIEKPGSSVQSAIK Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 -GAKG------------------------------------------------------- Lb_F2 -GAKG------------------------------------------------------- Pc_F2 -GAKG------------------------------------------------------- Pp_F2 -GAKG------------------------------------------------------- Um_F2 -PSES------------------------------------------------------- Ml_F2 SGAAM------------------------------------------------------- Ro_F2_a CST--------------------------------------------------------- Ro_F2_b YPT--------------------------------------------------------- Pb_F2_a LGS--------------------------------------------------------- Ro_F2_c G----------------------------------------------------------- Pb_F2_c GNGNGSGSGSGGG----------------------------------------------- Ro_F2_d VSG--------------------------------------------------------- Pb_F2_b HIS--------------------------------------------------------- Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 ------------------------------------------------------------ So_F2 ------------------------------------------------------------ Cn_F2 PAMPP------------------------------------------------------- Sj_F2 ------------------------------------------------------------ Cc_F1 -----------------------------------GPVSQMQKIALQRVNPDG------- Lb_F1 -----------------------------------GPVSQMQKIALQRVNQDG------- Pp_F1_a -----------------------------------GPVSQMQKIALQRVNADG------- Pp_F1_b -----------------------------------GPVSQMQKIALQRVNADG------- Pc_F1 -----------------------------------GPVSQMQKIALQRTNTDG------- Mg_F1 ----------------------GQHTSDDDDHHAWGAVAQMQKVALMRFVPTQGEWTLHA Um_F1 IDGGETAVSSAPTGATSTSANVGSETKEKDDLNLFGPVGQMQKVALMRFVPSNDSETVFG Pb_F1_a -----------------------------------GPISQMQKIALQLKSSVN------- Pb_F1_b -----------------------------------GPLSQMQKIALQLASSP-------- Ro_F1_a -----------------------------------GLLSQMQKVALQLANTP-------- Ro_F1_b -----------------------------------GPVSQMQKIALRLASSDP------- Ro_F1_c -----------------------------------GPVSQMQKVALRLL--DT------- So_F1 ------------------------------------YVNQMHRIVLESSTTLS------- Sc_F1 ------------------------------------YVNQMHRIVLESSASFS------- Sp_F1 ------------------------------------YVNQMHRIVLESAYPIS------- Sj_F1 ------------------------------------YLGQMHRIVLRRGQCNN------- Cc_F2 ----------------------IADHYCVPGEVCGDPVSQLHKIAFEVYD---------- Lb_F2 ----------------------IADHFCSPGEVCGDPVSQLHKIAFEVYD---------- Pc_F2 ----------------------IADHYCCPGEVCGDPVSQLHKIAFEVYD---------- Pp_F2 ----------------------IADHYCAPGEVCGDPVSQLHKIAFEVYD---------- Um_F2 ----------------------IAR------EAFGDPVSQLHKIALEVLEDPAASVPR-- Ml_F2 ----------------------SRDLPVAPGEIIGDPVSQLHKIALEVMSDPEGVYAN-- Ro_F2_a -------------------------GGEYGDEALGDPVSQLHKVAFQIVQDFSKIRQNKQ Ro_F2_b -------------------------GGEWGDEALGDPVSQLHKVGFQIVQDPSIAQYNKS Pb_F2_a -------------------------GGECGDEALGDPVSQLHKIAFQIVHDPLRQTAPIE Ro_F2_c -----------------------SLGGECSDETLGDPVSQLHKVAFQIVQDPSFHQGNLK Pb_F2_c ----------------------IGGGGECGDEVLGDPVSQLHKIAFQIVQDPSAHSVNTT Ro_F2_d ------------------------SGGEFGDEVLGDPVSQLHKIALQIVQDPK------- Pb_F2_b ------------------------GGGEYGDEVFGDPVSQLHKIALQIVQDPSNAVHAHH Mm_M ----------------------------------DDPVSQLHKCAFYLK----------- Hs_M ----------------------------------DDPVSQLHKCAFYLK----------- Xl_M ----------------------------------DDPVSQLHKCAFYLK----------- Dr_M ----------------------------------DDPVSQLHKCAFYLK----------- Dm_M ----------------------------------DDPVSQLHKCAFYMK----------- Hr_M ----------------------------------DDPVSQLHKCAFYLK----------- Ci_M ----------------------------------DDPVSQLHKCAFYLK----------- Ce_M ----------------------------------EEPVSQLHKCAFQMI----------- Mm_ML ----------------------------------DEPISQLHKCAFQFPSDTP------- Hs_ML ----------------------------------DEPISQLHKCAFQFPGSPP------- Dr_ML ----------------------------------DEPVSQLHKCAFQFR----------- Sp_F2 ----------------------------------SEAINCLSKLAFQCHETKRFLYID-- So_F2 ----------------------------------HESFNCLSKLAFQCPVSKKFLSID-- Cn_F2 ------------------------------GELASDLVSQLQKVAFEIYSPDTMNRLQ-- Sj_F2 ---------------------------------LGDSINCLSRLAFQCPRTKLFLN---- . : : : Cc_F1 ----------------------------------------------------SRHYLSAA Lb_F1 ----------------------------------------------------SRHYLSAA Pp_F1_a ----------------------------------------------------TRHYLSAA Pp_F1_b ----------------------------------------------------TRHYLSAA Pc_F1 ----------------------------------------------------TRHYLSAA Mg_F1 H--------------------------------------------------TPRTYLCAG Um_F1 DSEHLES-----------------------------------------NFSTPRSYLCGM Pb_F1_a ---------------------------------------------------SQPTYLSAG Pb_F1_b ----------------------------------------------------TPLYLSAA Ro_F1_a -----------------------------------------------------NLYLNSN Ro_F1_b ---------------------------------------------------QHPVYLSAA Ro_F1_c ---------------------------------------------------TEKLYLSCP So_F1 ----------------------------------------------------ANLAFGFR Sc_F1 ----------------------------------------------------TNLALGYE Sp_F1 ----------------------------------------------------NVRHLKIA Sj_F1 ----------------------------------------------------EPNVLKPY Cc_F2 ---------------------------------------PNKGLPEPGTPGVSGAFLSCM Lb_F2 ---------------------------------------STKGLPEPGTPGATGAFLSCM Pc_F2 ---------------------------------------PNKGAPEPGTPGVSGAFLSCM Pp_F2 ---------------------------------------PSRGVPEPGTPGPSGAFLSCM Um_F2 ---------------------------------------PTGDSGESNWPGNSGPFLACL Ml_F2 ---------------------------------------ANQSAPGSPFPG-AGSFLACL Ro_F2_a NHKQS----------------------------------FPLTQWTLPQVSSDVQYLACL Ro_F2_b TFQEQD-----------------------------KFFLPPVTHWTLPQATSAINYLACI Pb_F2_a N----------------------------------------CPEWSLPQSTDPITYLACL Ro_F2_c QN--------------------------------------TAGHWKIPQSSHPVTYLACL Pb_F2_c KSSDSNNDNTDCETNSNNNIS--------------QPFLLSTSSWNLPNSCQPVSYLACL Ro_F2_d ------------------------------------MSVMQAPDPRMPRTSQPVTYLACL Pb_F2_b AAMRQQTQSQNGDYDMNYSNSGVFSPTHLPTPAPAPAPVPQLQEKMMPRSNQPVTYLACL Mm_M ------------------------------------------------DTERMYLCLS-Q Hs_M ------------------------------------------------DTERMYLCLS-Q Xl_M ------------------------------------------------DTERMYLCLS-Q Dr_M ------------------------------------------------DTERMPLCLSPQ Dm_M ------------------------------------------------DTDRMYLCLS-Q Hr_M ------------------------------------------------DSERMYLCLS-Q Ci_M ------------------------------------------------DTERMYLCLS-Q Ce_M ------------------------------------------------DNELVYLCLS-H Mm_ML ------------------------------------------------GGAGTYLCLA-T Hs_ML ------------------------------------------------GGGGTYLCLA-T Dr_ML ------------------------------------------------GSDHMYLCLS-N Sp_F2 --------------------------------------------------EKQSSEISFT So_F2 --------------------------------------------------ELNSGEVGYT Cn_F2 -----------------------------------------------RESKYGGSWLSCY Sj_F2 ------------------------------------------------LDEFSNGEIRFL . Cc_F1 GP---------------------------------------------------------- Lb_F1 GP---------------------------------------------------------- Pp_F1_a GP---------------------------------------------------------- Pp_F1_b GP---------------------------------------------------------- Pc_F1 SP---------------------------------------------------------- Mg_F1 TPPNTYGDA--------------------------------------------------- Um_F1 VPGGWMHIS--------------------------------------------------- Pb_F1_a GNIITPTDQ----SSDHN------------------------------------------ Pb_F1_b GTLHEKSANNHHNSTTTN------------------------------------------ Ro_F1_a GKTIENDLN--------------------------------------------------- Ro_F1_b GSMSSEQDT--------------------------------------------------- Ro_F1_c -SIDD------------------------------------------------------- So_F1 DTKNA------------------------------------------------------- Sc_F1 NARSG------------------------------------------------------- Sp_F1 EHSS-------------------------------------------------------- Sj_F1 ANQQ-------------------------------------------------------- Cc_F2 GEKVNTYRPIEGRIWNTNVANNNGSSSP--VLPGSPMSP--------------------- Lb_F2 GEKVNTYRPIDGRQWNN---NQNGSNSP--ALPGSPISP--------------------- Pc_F2 GEKVNTYRPVEGRQWNAN-VTNTAEADSPIAAPGSPIAG--------------------- Pp_F2 GEKVNTYRPVDGRVWNAVPGAQSRESNSPIATPASPTDDG-------------------- Um_F2 NESVGMHRPSEPRRWVGNTSFSVPSTPTTPVTSMNLAAMEGIDPTGGYLSMSPTSAAAYA Ml_F2 GENVGIHRPEASRIPVAPASMISPPSSASSFGLTSSEVALAEATFMSN------------ Ro_F2_a NEVIGTHVVTGPRTIVSS------------------------------------------ Ro_F2_b HDVVGMHRVTDERKIVSR------------------------------------------ Pb_F2_a SEVVGMHRTTAPRTLLPVTDPAW------------------------------------- Ro_F2_c NDVVGMHKTTSTRHLVPQC----------------------------------------- Pb_F2_c NDAVGMHRTTSTRTLHKP------------------------------------------ Ro_F2_d NDMVGMHKTSEGR----------------------------------------------- Pb_F2_b NDMVGMHKTVDPRRPLATISQQTAAEAAATGAYFLKEETM-------------------- Mm_M ERIIQFQAT--------------------------------------------------- Hs_M ERIIQFQAT--------------------------------------------------- Xl_M ERIIQFQAT--------------------------------------------------- Dr_M ERIIQFQAT--------------------------------------------------- Dm_M EKIIQFQAT--------------------------------------------------- Hr_M ERIIQFQAT--------------------------------------------------- Ci_M ERIIQFQAT--------------------------------------------------- Ce_M DKIIQHQAT--------------------------------------------------- Mm_ML EKVVRFQAS--------------------------------------------------- Hs_ML EKVVQFQAS--------------------------------------------------- Dr_ML EKIIQFQAS--------------------------------------------------- Sp_F2 SGELEYSDP--------------------------------------------------- So_F2 EGEFQFNDK--------------------------------------------------- Cn_F2 QDEVREHAIKAERKWAVLQAPAGSKPASRPNSLPNTPQQRFGILPMTPHTNNMNLPSTPS Sj_F2 SADPAPGEG--------------------------------------------------- Cc_F1 -------------------------LPGTPGVVAPPAPGMSTQAGTHPLLFQNPRIRDEV Lb_F1 -------------------------IPGTPGVVAPPAPGMSTQAGTHPLLFQSPRIRDEV Pp_F1_a -------------------------MSGQPGVPVPPTPGLANQTGTHPLLFSIPRVREEV Pp_F1_b -------------------------MSGQPGVPVPPTPGLANQTGTHPLLFSTPRVREEV Pc_F1 -------------------------VPGQ-GTATSQSP--ANQTGTHPLVFQAPRVREET Mg_F1 -------GNSGGGNSSGIPLGS------GAGMARSDTSDDAHS---LPLTFASTRPLPWT Um_F1 -------PEKVGQQSLAVAFAQTHEEALGVGQLPAHTSDKHHTGETNSVVYATPKTVAVP Pb_F1_a -------GNTSSASITTTSLSSSSSAAAAAAVGSPSS----NQNSNAWLDISPS-----Q Pb_F1_b -------TNTTNSTPTTTTTTTTTTATTATTNNSNTTTLDHDNHANTWLDFAPSRLTNSD Ro_F1_a --------------------------------------------NNVYIDFTAI------ Ro_F1_b --------------------------------------------HQTWLDYSPS------ Ro_F1_c ---------------------------------------------QTWLDSRPS------ So_F1 --------------------------FMQDDQVQSRWFLGATSAQCKNLPNEAVVPVEWE Sc_F1 --------------------------FMPADRTQPRWFLGATSAQCKNLPNEAVVPVEWE Sp_F1 --------------------------LAYSNNISVRWFLGATSAQNRNASSEAILPIEWE Sj_F1 ----------------------------GMDFVQP-LFLGATTAQEKSTTGDMDFPVELE Cc_F2 ------TNGSASAEYFGQATGANESEPASPSSAEFLSNDGGRVKK-KRSTSSAGG----- Lb_F2 ------TPGSANSEYFGLG----DSAPASPSATDFMSNDGGRVKK-KRSTSSAGG----- Pc_F2 ----TPTSANGHGDYFGGNGGS-GSAPNSPIPTEFPSSDGGKVKKGKRGSSSAGG----- Pp_F2 ----TPTSTTGSVDYFG-SGSM-SSTPTSPA-ADFPSNDGGRVKKAKRGSSSAGT----- Um_F2 AAQTRYSLSAGRAGATMMSPSASTGSHDVSAMEPPPSSDGGKVKRPRRVSSSVVVQKERA Ml_F2 ----QLTQPISPNSAAPGRARSVGPAGRIGDTMEYISSDGGKVKRTRRVSTSQSSSSGMG Ro_F2_a -------------------------------FMPKLEQADAQISRKRRLSYQYSSLTSKP Ro_F2_b -------------------------------FTTEIEDIKMAV-RKRRLSYQQHSTTVKS Pb_F2_a -------------------------PYEYDLLSSAVSQENGRVVRKRRVSCDVTKPVTLP Ro_F2_c -----------------------------------QENTFGEIAQDPIVRRLSTGEI--- Pb_F2_c -----------------------------------------EAPKRPVEP---------- Ro_F2_d -------------------------SWAGWDDSITSQ-EGGKIIRKRRVSTDVQP----- Pb_F2_b ------------------------NNYNTIDSSVPSQQEGGKVVRKRRVSTDVLERHLNS Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 ------------------------------------------------------------ So_F2 ------------------------------------------------------------ Cn_F2 SPVSSSSSLDYFNYQSQRSSGHNHPLMSPGSVETALPSTDGGPIRRQRTSSMGKGPLSRP Sj_F2 ------------------------------------------------------------ Cc_F1 RDGIR------------------------------------------------------- Lb_F1 RDGER------------------------------------------------------- Pp_F1_a KDNQN------------------------------------------------------- Pp_F1_b KDNQN------------------------------------------------------- Pc_F1 RDGVR------------------------------------------------------- Mg_F1 QH---------------------------------------------------------- Um_F1 KENAPGI----------------------------------------------------- Pb_F1_a PSKNNND----------------------------------------------------- Pb_F1_b PGSGSFD----------------------------------------------------- Ro_F1_a ------------------------------------------------------------ Ro_F1_b ----RKL----------------------------------------------------- Ro_F1_c ----TLS----------------------------------------------------- So_F1 PIQTLN------------------------------------------------------ Sc_F1 PIETYN------------------------------------------------------ Sp_F1 AVGNLSS----------------------------------------------------- Sj_F1 PATSIDE----------------------------------------------------- Cc_F2 LSKAVG----------------------------------------GKGRRRPSSAGSVS Lb_F2 ITKNVG----------------------------------------AKGRRRPSSAGSVS Pc_F2 LSKPAS----------------------------------------QKGRRRPTSAGSAS Pp_F2 ASKSTS----------------------------------------AKGRRRPTSAGSAG Um_F2 AAAAAA----------------------------------------SKSRRRGQSLSMVG Ml_F2 RVIGPG----------------------------------------KAGRRRAGSNASTG Ro_F2_a S-----------------------------------------------SSRRVNSLNDEL Ro_F2_b S-----------------------------------------------NRRRVNSLNDEL Pb_F2_a AKFQSA--------------------------------------MSAKNRRRVNSLNDAL Ro_F2_c ------------------------------------------------KRRGSLGKGSSA Pb_F2_c ------------------------------------------------SRR----NSATA Ro_F2_d ------------------------ETLMSCMSLSDYP------------RRRVNSLED-- Pb_F2_b GLNNYNLNMSMSMNMNMNMNGIPPSKLVSSMSLTNLKERNQGEILDPSLRRRVNSMNDDI Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 ------------------------------------------------------------ So_F2 ------------------------------------------------------------ Cn_F2 LHRKRLSTDSTG------------------------------------------------ Sj_F2 ------------------------------------------------------------ Cc_F1 ------------------------------------------------------------ Lb_F1 ------------------------------------------------------------ Pp_F1_a ------------------------------------------------------------ Pp_F1_b ------------------------------------------------------------ Pc_F1 ------------------------------------------------------------ Mg_F1 ------------------------------------------------------------ Um_F1 ------------------------------------------------------------ Pb_F1_a ------------------------------------------------------------ Pb_F1_b ------------------------------------------------------------ Ro_F1_a ------------------------------------------------------------ Ro_F1_b ------------------------------------------------------------ Ro_F1_c ------------------------------------------------------------ So_F1 ------------------------------------------------------------ Sc_F1 ------------------------------------------------------------ Sp_F1 ------------------------------------------------------------ Sj_F1 ------------------------------------------------------------ Cc_F2 S--------------------------------------------------------RRG Lb_F2 SS-------------------------------------------------------RRG Pc_F2 GSI---------------------------------------------------SSSRRG Pp_F2 -------------------------------------------------------SGRRA Um_F2 IQNQG-----------------------------------LSEVEVLRRNGSYANSMTSD Ml_F2 GYSDLGTES------------------------------SDGMHHNYHPHHHHSMQHGAY Ro_F2_a LS---------------------------------------------SDTGHCR------ Ro_F2_b LSRHV-----------------------------------------GGDAGRCPD----- Pb_F2_a PDTTQRRA------------------------------------SQSSVTGSRRPST--- Ro_F2_c LDPTG------------------------------------------------------- Pb_F2_c QDLS-------------------------------------------------------- Ro_F2_d PAPYLARK---------------------------------SSVSSLSSTTSR------- Pb_F2_b EAYYGSRANGGSAASHILMNRGRSGSTHSLENSKRKPSMSASSSSSSTSTGSRRMSAVSV Mm_M ------------------------------------------------------------ Hs_M ------------------------------------------------------------ Xl_M ------------------------------------------------------------ Dr_M ------------------------------------------------------------ Dm_M ------------------------------------------------------------ Hr_M ------------------------------------------------------------ Ci_M ------------------------------------------------------------ Ce_M ------------------------------------------------------------ Mm_ML ------------------------------------------------------------ Hs_ML ------------------------------------------------------------ Dr_ML ------------------------------------------------------------ Sp_F2 ------------------------------------------------------------ So_F2 ------------------------------------------------------------ Cn_F2 ---------------------------------------------SNSYEYMPSLSSAMS Sj_F2 ------------------------------------------------------------ Cc_F1 -----------VISDEVDDYLCWTIVGISKFQYTFFD----------------------- Lb_F1 -----------IISDEVDDYLCWTIVGISKFQYTFFD----------------------- Pp_F1_a -----------VIIDEVDDYLCWTIVGISKFQYTFFD----------------------- Pp_F1_b -----------VIIDEVDDYLCWTIVGISKFQYTFFD----------------------- Pc_F1 -----------VITDEVDDYLCWTIVGISKFQYTFFD----------------------- Mg_F1 -----------VVMDEAEDAFCWTLVGISHFEYAFMD----------------------- Um_F1 -----------KLVDEVDDAFVWTVIGVSRFEYSYFD----------------------- Pb_F1_a -----------PKVEVVDDYLCWTIVSIAKFEYTFADPIMVGMDVSPCSKMAESRLVPSS Pb_F1_b -----------TQCEEVDDYLCWTIVGISKFQYTYSD---------------------GS Ro_F1_a ------------QDQQVSDYLCWTIVGISKFEYEFIQ----------------------- Ro_F1_b -----------EQ-EEIDDYLCWTIVGIHTLEGEFDER---------------------- Ro_F1_c -----------ENGEQVDDALCWTMVGIHVLEDHFDE----------------------- So_F1 -----------DGLVKIRDSVCWTIVGISQCDCSILRP---------------------- Sc_F1 -----------DEVLKIRDSVCWTIVGISQCDCTILRP---------------------- Sp_F1 -----------NEMTRVGDSVCWTIVGISHFDCTMMLP---------------------- Sj_F1 -----------SGSIRVSDAVCWTVIGISHYEFSMMNA---------------------- Cc_F2 SGSDSGASSGALWQVDIGETSVWTIVGTDQIRYNFYVPP--------------------- Lb_F2 SGSDAGASSGALWQVDIGETSVWTIVGTDQIRYNFYVPP--------------------- Pc_F2 SSSDSSASSGALWQVDIGETSVWTIVGVDQVRYNFYVPP--------------------- Pp_F2 SASDSSASSGALWQVDIGETSVWTIVGTDQVRYNFYVPP--------------------- Um_F2 SSAAGSIAPGAMWSVEVADSDIWTVVGTDIARHSFYVPP--------------------- Ml_F2 SAPQHPPNAAKVWTIECGEPAVWTIVGCDVERHTFWIPP--------------------- Ro_F2_a -----QRLNGDCWAEDVSDVSIWAIVSADSATFTFWTS---------------------- Ro_F2_b -----QPLNGDCWTEDVSDSAVWTIVGTNSTSFAFWTP---------------------- Pb_F2_a --DSLQGINGGCWTEDVSDAAIWTIVGTDCATYTFWTPS--------------------- Ro_F2_c -------LEGACWTEDVSDAAVWTIVGTDCASYTFWTP---------------------- Pb_F2_c -------LDGSCWTEDVSDAAVWTIVGTDCASYTFWTP---------------------- Ro_F2_d ------PHLGAFWSEDVSDAAVWTLVGTDCATYTFWSPF--------------------- Pb_F2_b NAGSPNHGLGSYWSEDVSDAAVWTIVGTDCAVYTFWTPP--------------------- Mm_M ------PCPKEQNKEMINDGASWTIISTDKAEYTFYEGM--------------------- Hs_M ------PCPKEPNKEMINDGASWTIISTDKAEYTFYEGM--------------------- Xl_M ------PCPKEPNKEMINDGASWTIISTDKAEYTFYEGM--------------------- Dr_M ------PCPKETNKEMINDGASWTIISTDKAEYTFYEGM--------------------- Dm_M ------PCPKEPNKEMINDGACWTIISTDKAEYQFYEGM--------------------- Hr_M ------PCPKEPNKEMINDGASWTIISTDKAEYTFCDGM--------------------- Ci_M ------PCPKETNKEMINDGASWTIISTDKAEYTFCDGM--------------------- Ce_M ------AIN--EHRHQINDGAAWTIISTDKAEYRFFEAM--------------------- Mm_ML ------LCPKEANRALLNDSSCWTIIGTESVEFTFSTSL--------------------- Hs_ML ------PCPKEANRALLNDSSCWTIIGTESVEFSFSTSL--------------------- Dr_ML ------PCPKESNKVSLNDGSCWTIIGTEVVEYSFSESL--------------------- Sp_F2 ------NDPTKATHSVLPWSAMWSIISTQSVRTMFYNEP--------------------- So_F2 ------LNPSRATHSVLPWSAMWSIISTQSFNTNFYDEP--------------------- Cn_F2 SAEQPVQPQRMFWTMDVGDSCVWSIISVEQASYTFFTPPISN------------------ Sj_F2 --------DGNGEYVNLPWSAVWSIITTQSVRTMFFDDCS-------------------- *::: Cc_F1 AFGQNNKIPE----------------TPITPFPTLFTAPVYRAANN-------------- Lb_F1 AFGQNSNIPE----------------LPITPFPTLFQAPVYRPANN-------------- Pp_F1_a AFGQNSKIPD----------------LPITPFPTLFTAPVHRFERERGT----------- Pp_F1_b AFGQNSKIPD----------------LPITPFPTLFTAPVHRFERERGT----------- Pc_F1 AFG-HTDPPE----------------APITPFPTLFTAPALATGAGSEP----------- Mg_F1 VDMLGLHSPSASMG------------LALTPFPLVTTMPFYDAASH-------------- Um_F1 TSATQASKDEGPCE------------VPMTPFPLITSMPIYDQTRH-------------- Pb_F1_a ASSSSYSSPSHSPSPSSLTCRHAQPSPPPSPPRTIVPYPSLSSVSYNH------------ Pb_F1_b QQTTTAGQPSPPLSP-----------LVPLSPRNLTPFPILSAVKYDP------------ Ro_F1_a -SPIEIQQPNS---------------PPPSPPRSIIPFPTISCIQYIP------------ Ro_F1_b ----QPTTPSS---------------PPPEQPRLVNPYPYLTHLQYKP------------ Ro_F1_c ---------------------------PPAR-----PYPVVTCMDYQP------------ So_F1 --------------------------LQNQTSLRQLNLPYVKAPPV-------------- Sc_F1 --------------------------VQSQFALRHLDLPCVEAPPI-------------- Sp_F1 --------------------------FNQNPVPTVTDYPYIEEPPE-------------- Sj_F1 --------------------------LNARITQPITPFPVVETSPK-------------- Cc_F2 VLFDNQHAQPSSLGAFPIPS------KQVTPFPGVVKYLPPDRASEAPKSNCAQSRAVLA Lb_F2 LLFDNQHAPQT--GSFPIPS------KPITPFPGVVKYLPPDRAAEVPKSNCVQSRAMLS Pc_F2 VLFDNQSAPQT--GSFPIPS------KPVTPFPNVVKYLPPDRAAEAPKP-CPQSRAMMA Pp_F2 VLFDNQNAPQT--GSFPITS------KPVTPFPGVVKYLPPDRAAEVPKH-HASARAALT Um_F2 QIVGG-SQPQTNITDSNIAH------LITVPAPAQPITPIPIISNMVAPQRDARSQPMSA Ml_F2 VLFDSKPSSAAS-TQGAVSE------VFRTPIPYCPIGVDSPTPIPVVHKYLLTNPISMP Ro_F2_a PC-SIRSVTAP-----------------ITPFPTIMNIKKISNQS--------------- Ro_F2_b PD-YSKPFFD------------------LQDFPYVDSIQSLSST---------------- Pb_F2_a PL-ANSSDLRP-----------------VTPFPRLT--HKICRSL--------------- Ro_F2_c ---DERTMPT-------------------APFPVLHELTK-------------------- Pb_F2_c ---DIARTQSG-----------------LAHFPIINNLTMSSTTSCNGSNINS------- Ro_F2_d LDDPSTPLSTG-----------------P--FPALSHFFTSTN-----------KLD--- Pb_F2_b VDDTRPQLSVN-----------------TTMFPTLLNYTLNMSPSVAYQTQQSTGLDRRL Mm_M GPVLAPVTPVP----------------------VVESLQLNGGG---------------- Hs_M GPVLAPVTPVP----------------------VVESLQLNGGG---------------- Xl_M GPINAPVTPVP----------------------VVESLQLNGGG---------------- Dr_M GPVPSPVTPVPV---------------------VVESLQLNGGG---------------- Dm_M GPVASPVTPVP----------------------IVNSLNLNGGG---------------- Hr_M GPTSKPVTPVP----------------------VVHSLQLNGGG---------------- Ci_M GPTADPVTPVP----------------------NVHSLQLNGGG---------------- Ce_M GQVANPISPCP----------------------VVGSLEVDGHG---------------- Mm_ML ACTREPVTPVP----------------------LISTLELSGGG---------------- Hs_ML ACTLEPVTPVP----------------------LISTLELSGGG---------------- Dr_ML TGHPATISPVP----------------------VISGLELNGGG---------------- Sp_F2 --------------------------IHQNAFHVVPSMPFVKFIRL-------------- So_F2 --------------------------IFKNRTHSVPSMPSVKCLYS-------------- Cn_F2 FEEFEPVAPFP---------------VANRLLPANLSAEVPSKYAHHYT----------- Sj_F2 ---------------------------GNDGMLSIPSAPIIKFIRMD------------- Cc_F1 ------TIELTVSNFFYAHPKTRMQTP----LDVYLGSLGPLHTRVYQTSPPG---PLTS Lb_F1 ------TVELTVSNFFFENPKTRQQSP----LDVYLGNLGPLRLRVYQATPPG---PMTN Pp_F1_a -----EQLELTASNFFYENPATGTVEP----LDVYLGPIGPLHIRIFHSSVPVGQVPMPF Pp_F1_b -----EQLELTASNFFYENPATGTVEP----LDVYLGPIGPLHIRIFHSSVPVGQVPMPF Pc_F1 -----CTLDLTVANFFYRHPHTNEQTP----LSIYLGNLGPLRHRINAPYPPG---PLTS Mg_F1 ------KLAMTVQHFLYVRNSAALQTP----RDAYEAIHAESQSSQLEALEVWIGPLGPL Um_F1 ------TLVTTVTNFIVPAAITSDPIP----LDVWAGSLGPLKVSHSTNAPSTS------ Pb_F1_a -----TLHAIDVVGHHLFQKSTMPPRL----LEFWLGNHGPLKQVP-------------- Pb_F1_b -----RTHRLNITGRHLRQATTG--RL----LAIWLGTDGPLQLDVRSDSFEL------- Ro_F1_a -----STHSIRVPSTEFN---------------YYLGRQGPLKKKS-------------- Ro_F1_b -----ETNTLEAIGQHLIQAAPVP-RL----LEPWLGTHGPLPTRI-------------- Ro_F1_c -----NTHTLELFGHNLHPS-----------VQPWLGTHGPLNTRL-------------- So_F1 ---------YSPSNKSLELTVAGFSPD----LQIWLGKLGPFDYTIL------------- Sc_F1 ---------YLPSNQSLELSIEGFSPD----IQIWLGNIGPLNYTKI------------- Sp_F1 ---------YLESSRSLQFKIGGYSVG----LQIWLGVHGPLSYSFT------------- Sj_F1 ---------YIGETHSLELLVSGCTPK----TQVWLGPYGPLAYTR-------------- Cc_F2 KP-----NPHAAKLLTVYGENFSKTDP----VHVFFGSEPSP------------------ Lb_F2 KP-----SPHASKMLTVYGENFSKTDP----VNVFFGSEPSP------------------ Pc_F2 KP-----NPHASKMLTVYGENFSKTDP----VTVFFGSDPSP------------------ Pp_F2 KP-----NPHTSKMLTIYGENFSKTDP----VTVFFGSEPSP------------------ Um_F2 QA-----GEQSPGLVTILGENFHPN------LFIFFGDWKST------------------ Ml_F2 KNR---IDAQDMKMITIYGANFSRE------LRVWFGAVPSE------------------ Ro_F2_a ---------LTIFTLILSGENFKHD------VTVWFGDIQSP------------------ Ro_F2_b -------------VLSLVGEHFTSD------LTVWFGDVPSI------------------ Pb_F2_a ---------DTSDNLVLSGEGLSAK------LSVWLADIQLK------------------ Ro_F2_c ---------KGKDRLTLTGENLSPD------IEVWFGDVKST------------------ Pb_F2_c -------SSNGGDLLTLTGEHITRD------LKVWFGDIEA------------------- Ro_F2_d ----------HERFLTMHGENFSRD------LQVWFGDVKAN------------------ Pb_F2_b QSTGEEYPDSNEQLMSLHGESFSRD------LQVWFGDIKAL------------------ Mm_M ----------DVAMLELTGQNFTPN------LRVWFG-DVEA------------------ Hs_M ----------DVAMLELTGQNFTPN------LRVWFG-DVEA------------------ Xl_M ----------DVAMLELTGQNFTPN------LRVWFG-DVEA------------------ Dr_M ----------DVAMLELTGQNFTPN------LRVWFG-DVEA------------------ Dm_M ----------DVAMLELSGDNFTPH------LQVWFG-DVEA------------------ Hr_M ----------DVAMLEVNGENFSPQ------LKVWFG-EVEA------------------ Ci_M ----------DVAMLEVNGECFTSN------LKVWFG-EIEA------------------ Ce_M ----------EASRVELHGRDFKPN------LKVWFG-ATPV------------------ Mm_ML ----------DVATLELHGENFHAG------LKVWFG-DVEA------------------ Hs_ML ----------DVATLELHGENFHAG------LKVWFG-DVEA------------------ Dr_ML ----------HVAMLELHGENFSPH------LRVWFG-NMEA------------------ Sp_F2 ---------DENSMFHIYGTGFAND------VQIWMAYTRCEVKSINA------------ So_F2 ---------DKQSLLYIYGTGFAND------VQVWIGDAKCDVLKKAG------------ Cn_F2 -------TTTNMPLVTLYGKHFVKNVDGLAKHVMYYGDEPAR------------------ Sj_F2 ----------ESNMLHVYGVNFTAD------AQVWIGENPCQTYSVT------------- : . Cc_F1 ISPFVPVTP-VEVPPPAGDPN------APANRYVSTGPLHTIVIVELPPLADVIKAMEDE Lb_F1 VSPYGQAPHGLDGGGPSSDSLGLPIGAASTQRYVASGPLHTIVIVEMPPLTDVIKALEDD Pp_F1_a IHPAMPGEA--PVDPSVSSYP-----TGRRPPGAIHGPLTTTVLVDLPHKSDVMKALEED Pp_F1_b IHPPMPGDAPIPVDPSTSSYP-----TGRRPPGALHGPLTTTVLVDLPHKSDVMKALEED Pc_F1 VSPYVQAIGPDGVQRDEPIGPG--VSPLERSPYLAANPIHTSITVDLPPMADILRSLQED Mg_F1 TLASVPVPE----------------------------SDEAEVAVQLPPLREILQARLDP Um_F1 TSTSTSTST----------------------------DPETYITVTLPAIREMIKVALTA Pb_F1_a -------------------------------------HETSLVRVELPPTQDLLVANHNI Pb_F1_b -------------------------------------PNTSNLIVHLPPTQDLLVANHDL Ro_F1_a -----------------------------------------LIELELPDIQDILLNHHNL Ro_F1_b --------------------------------------------ASPPETHTPHEIHWSI Ro_F1_c --------------------------------------------MQPN--------HWSI So_F1 ------------------------------------------DGTEKKPSMYVRILVSMN Sc_F1 ------------------------------------------EKAEKSLSRSVTILVSLI Sp_F1 ------------------------------------------AAADTSTMGTVTLGLSQI Sj_F1 ------------------------------------------QETEKADENLLIVSLPYI Cc_F2 -------------------------------------------YVEVRCTEVLGCLPPES Lb_F2 -------------------------------------------YVEVRCTEVLGCLPPES Pc_F2 -------------------------------------------YVEVRCTEVLGCLPPE- Pp_F2 -------------------------------------------YVEVRCAEVLGCLPPE- Um_F2 -------------------------------------------HVDVRTRQTIVCAAPPS Ml_F2 -------------------------------------------IVEYKCAEVIVALPPSG Ro_F2_a -------------------------------------------TTRFESDKLISCIVPDY Ro_F2_b -------------------------------------------QTEFKSSQLLSCTVPER Pb_F2_a -------------------------------------------TEYHKDT--LSCIVPPA Ro_F2_c -------------------------------------------ETEFVSQDSVHCKIP-- Pb_F2_c -------------------------------------------KTDYQSRESIRCVVPDT Ro_F2_d -------------------------------------------HTEYRSRELIICKVPPR Pb_F2_b -------------------------------------------DSDYRSRELFVCRLPTR Mm_M -------------------------------------------ETMYRCGESMLCVVPDI Hs_M -------------------------------------------ETMYRCGESMLCVVPDI Xl_M -------------------------------------------ETMYRCAESMLCVVPDI Dr_M -------------------------------------------DTMYRCGESVLCVVPDI Dm_M -------------------------------------------ETMYRCTETLLCVVPEI Hr_M -------------------------------------------DTMYRCEEGLLCVVPDI Ci_M -------------------------------------------DTMFRCAEGLLCVVPDI Ce_M -------------------------------------------ETTFRSEESLHCSIPPV Mm_ML -------------------------------------------ETMYRSPRSLVCVVPDV Hs_ML -------------------------------------------ETMYRSPRSLVCVVPDV Dr_ML -------------------------------------------ETMFRSSRSLLCVVPDV Sp_F2 ------------------------------------------FKPDTTLPPDIISDSRFS So_F2 ------------------------------------------DPLNTSTLPDVVSSSRFC Cn_F2 -------------------------------------------HNEVRCAEVMVASEPEQ Sj_F2 -------------------------------------------DVEIDEPTLLRGLISTS Cc_F1 PVPTASDVSG-SKPHQESEGQEG-VPPPPPPPPSMAGRSLPLLFIRSSDGVGYHSGRTIA Lb_F1 ALPAHSDGSAPARQSPEQANQEASSTTAPPPPPSIAGRSLPLLFIRASDGVGYHSGRTIA Pp_F1_a AVPPAGEGGDVAANRTQS------------KVERLSGRSLPLLFIRAFDGVGYHSGRAVA Pp_F1_b AVPPAGESGDVAANRTQS------------KVERLSGRSLPLLFIRAFDGVGYHSGRAVA Pc_F1 LEPPRDGAAPQNGTSTDP----------KLNVAALNGRSLPLLFIRAADGVGYHSGRAIA Mg_F1 WKTPLS------------------------SCTLP------ILFVRAYDSTIYHSGRHVL Um_F1 RRSSPT------------------------SAPIPPHVLLPLIFVNDSDGTAYHSGRHIV Pb_F1_a LQR---------------------------QANGERHLELALVLVR-QDGMVYPTGKSLS Pb_F1_b LTPDPD------------------------MGAGYRQLELPILLVR-HDGVVYHSSKSLL Ro_F1_a LST---------------------------QQDGSRYLELPILLSKPNDTFIYHSSKLLS Ro_F1_b DLS----------------------------SVKQQTEELPLLLVR-QDGLVYHTGKSLK Ro_F1_c ALP----------------------------PLEQLVGELPLLMVR-QDGLVYHTGKTFS So_F1 YIC----------------------------TEVMASNVLPLLFVY-SDGTVVSGGYDIT Sc_F1 QLS----------------------------TEAITCETLPLLFVF-PDGTIVSGRCDIS Sp_F1 SY-----------------------------DPSCAEQKYPLLFVI-PGGIVIIGKCEIL Sj_F1 EV-----------------------------NTTNPWTTLPLLFTR-PNGLIYVGKCDVV Cc_F2 ---------------------------------GHNNKRRPIILLR-SDGVVFPSNVMYP Lb_F2 ---------------------------------APS-KRRPIILIR-SDGVVFPSNTMYP Pc_F2 ---------------------------------SNNMKRRPIILVR-HDGVVFPSNTYYP Pp_F2 ---------------------------------SQSAKRRPVVLVR-YDGVVFPSNVYYP Um_F2 FD------------------------------QGLPRGRVPILIVR-HDGVIFPTDFHYQ Ml_F2 VPGELG--------------------------PDGGPKKHQIVMVR-EDGVVFPSKIYYA Ro_F2_a KELQNSPVIQVNSS--------------------TSERQLPLLLVR-TDGVIYNPRLFYS Ro_F2_b HELLDSFATQLDPD--------------------TSRHKIPLLLVQ-EDGIIYNSLLFYS Pb_F2_a EELVNNPFVEYSEH--------------------SSRRSLPLLLVR-DDGVVYKTESVYD Ro_F2_c --FDVANSTTIEQE--------------------NDHRRIPLLLVR-GKGIVYKTNLYYI Pb_F2_c HILETSLATTIDEELVID-------------GSIGPNRRLPLLLVR-NDGLVYQTDFFHT Ro_F2_d HELME---------------------------VKKVYGDLPILLVR-GDGTICKTGKCFS Pb_F2_b QNLLEGVGLETVGFD--N-------------TTHAPIYSLPILLVR-GDGTVYKTNKTYK Mm_M SAFREG---WRWVRQP---------------------VQVPVTLVR-NDGVIYSTSLTFT Hs_M SAFREG---WRWVRQP---------------------VQVPVTLVR-NDGIIYSTSLTFT Xl_M SAFREG---WRWVRQP---------------------VQVPVTLVR-NDGVIYSTSLTFT Dr_M SAFREG---WRWVRQP---------------------VQVPVTLVR-NDGIIYSTALTFT Dm_M SQFRGE---WLWVRQP---------------------TQVPISLVR-NDGIIYATGLTFT Hr_M SEFREG---WTWVKQS---------------------VQVPINLVR-HDGIIYPTNLTFT Ci_M SAFREG---WKWVKES---------------------VQVPINLVR-NDGVIYPTNLTFT Ce_M SQVRNEQTHWMFTNRTT------------------GDVEVPISLVR-DDGVVYSSGLTFS Mm_ML AAFGSD---WRWLRTP---------------------ITVPVSLLR-ADALFYPSPFSFT Hs_ML AAFCSD---WRWLRAP---------------------ITIPMSLVR-ADGLFYPSAFSFT Dr_ML SILSGE---WRWTRQP---------------------ITVPLSLIR-LDGLIYRSWFSFT Sp_F2 SRVYACT-------------------------ANLIELICEIPVCMFEPTVELSPILLFQ So_F2 SRLQAFP-------------------------VNLTCIACVVPFHLWESKIKKNPILLFQ Cn_F2 SAK--------------------------------SDRKRPIFLVREDGKVIIPTPLHYP Sj_F2 HVPPRLHAYLADLADIICQP-----------PALSVTTSPELPILVSQQNIIFHSGFTWP : . Cc_F1 CEPIHYSLDLAAMAPNGPNGV----DPQWLAAAQAAAAADGNMQPWTLRVM--------- Lb_F1 CENVFQTMDLAGIPGNPPNGVPGNIDTGWLAAAQAAAAADGGLHGWTLRVM--------- Pp_F1_a CEYIFKDVDLLTPPPGE--------DGREWVAEQAAQAAENNLNSWAFRVL--------- Pp_F1_b CEYIFKAVDLLTPPPGE--------DEREWVAEQAAQAAENNLNSWAFRVL--------- Pc_F1 VENIFQSLEINGRTDDQ----------AWLAQAQGMQGLEAAMHSWSLRVI--------- Mg_F1 CQDLVAVVRAAGDSSAANALQ----KLNVGLGEQAGAHELPPGSVWTLRVI--------- Um_F1 CEDLVQLMKATGHDTTADVLK----QLGFGLGDLAGP---PNDGAWSVRII--------- Pb_F1_a CAVSVNGD--TSRWYVVPTHS----------HSLS------------------------- Pb_F1_b CRLSDKGDPLPEVWTVIPSST----------GPA-------------------------- Ro_F1_a FTFLMHSPE-SGQFSILDCHT----------KR--------------------------- Ro_F1_b WDQEGEGWLCK------------------------------------------------- Ro_F1_c TNS------CT------------------------------------------------- So_F1 LPSRHLLGKSL------------------------------------------------- Sc_F1 LSPWLSLGK--------------------------------------------------- Sp_F1 LTS-SAFGN--------------------------------------------------- Sj_F1 VR---------------------------------------------------------- Cc_F2 ------------------------------------------------------------ Lb_F2 ------------------------------------------------------------ Pc_F2 ------------------------------------------------------------ Pp_F2 ------------------------------------------------------------ Um_F2 C----------------------------------------------------------- Ml_F2 EPM--------------------------------------------------------- Ro_F2_a F----------------------------------------------------------- Ro_F2_b F----------------------------------------------------------- Pb_F2_a F----------------------------------------------------------- Ro_F2_c L----------------------------------------------------------- Pb_F2_c F----------------------------------------------------------- Ro_F2_d L----------------------------------------------------------- Pb_F2_b FQ---------------------------------------------------------- Mm_M YTPEPGPRPHC-SAAGAILRA----NSSQVPSNE--------------SNTNSEGNYTNA Hs_M YTPEPGPRPHC-SAAGAILRA----NSSQVPPNE--------------SNTNSEGSYTNA Xl_M YTPEPGPRPHC-SAAGAILRA----NSSLLASNE--------------PNTNSEGSYTNI Dr_M YTPEPGPRPHC-SAAGAILRA----NSNSSTSPS--------------SSSSASSLLLQS Dm_M YTPEPGPRPHCNTQAEDVMRARQNNNNNNITSIS--------------NNNNSNNAGSPA Hr_M FTPEPGPR----PTLARLLYI----SSTP------------------------RDRIMPD Ci_M FTPEPGPRQHC-PAALNILHG----SKRPSASMPPTPVSGSEDDSGRGNESDRGDPIMPI Ce_M YKSLERHGPCR--IVSNY------------------------------------------ Mm_ML YTPEYSALPRLPNAQEPAPDA---------------------------------DTLLES Hs_ML YTPEYSVRPGHPGVPEPATDA---------------------------------DALLES Dr_ML YTPEHSASSQTSGSGERSADS---------------------------------DALIDT Sp_F2 YETLFHSGYKWPLESH-------------------------------------------- So_F2 HDTFFNSGFAWPLHS--------------------------------------------- Cn_F2 V----------------------------------------------------------- Sj_F2 IHPHTL------------------------------------------------------ Cc_F1 ----------------------------------- Lb_F1 ----------------------------------- Pp_F1_a ----------------------------------- Pp_F1_b ----------------------------------- Pc_F1 ----------------------------------- Mg_F1 ----------------------------------- Um_F1 ----------------------------------- Pb_F1_a ----------------------------------- Pb_F1_b ----------------------------------- Ro_F1_a ----------------------------------- Ro_F1_b ----------------------------------- Ro_F1_c ----------------------------------- So_F1 ----------------------------------- Sc_F1 ----------------------------------- Sp_F1 ----------------------------------- Sj_F1 ----------------------------------- Cc_F2 ----------------------------------- Lb_F2 ----------------------------------- Pc_F2 ----------------------------------- Pp_F2 ----------------------------------- Um_F2 ----------------------------------- Ml_F2 ----------------------------------- Ro_F2_a ----------------------------------- Ro_F2_b ----------------------------------- Pb_F2_a ----------------------------------- Ro_F2_c ----------------------------------- Pb_F2_c ----------------------------------- Ro_F2_d ----------------------------------- Pb_F2_b ----------------------------------- Mm_M STNSTS---------VTSSTATVVS---------- Hs_M STNSTS---------VTSSTATVVS---------- Xl_M STNSAN---------VTSSTAAVVS---------- Dr_M AVDSQAGYGASGGVSTSSSSAMSVS---------- Dm_M AGGGLQQQQQQHQALPSISEVQWNSHGSGLS---- Hr_M RVPGRGVLIR-----PTWTTT-------------- Ci_M KRPALDVHGR-----PVAPEAAATMNGANMLRTAS Ce_M ----------------------------------- Mm_ML IHHEFTR---------TNFHLFCPT---------- Hs_ML IHQEFTR---------TNFHLFIQT---------- Dr_ML IHQEFTR---------TNFHLFMQS---------- Sp_F2 ----------------------------------- So_F2 ----------------------------------- Cn_F2 ----------------------------------- Sj_F2 -----------------------------------