Both larvae carry an attP docking site integrated into the genome via piggyBac-mediated germline transformation using a cyan fluorescent marker (see article by Labbé et al., doi:10.1371/journal.pntd.0000788). The top larva also carries a 3xP3-DsRed2 marker—leading to expression of DsRed2 red fluorescent protein and hence prominent red fluorescence in the eyes and optic nerve—integrated into the attP site via PhiC31-mediated site-specific integration. Development of gene transfer technology for Aedes albopictus is a key step in the study and control of this invasive species using novel molecular techniques and genetic control strategies.
Image Credit: Geneviève Labbé/Oxitec Ltd.
Editorial
Neglected Tropical Disease Control in the “Post-American World”
PLOS Neglected Tropical Diseases: published August 31, 2010 | https://doi.org/10.1371/journal.pntd.0000812
Review
Coronary Microvascular Disease in Chronic Chagas Cardiomyopathy Including an Overview on History, Pathology, and Other Proposed Pathogenic Mechanisms
PLOS Neglected Tropical Diseases: published August 31, 2010 | https://doi.org/10.1371/journal.pntd.0000674
Research Articles
Osteopontin Impairs Host Defense during Established Gram-Negative Sepsis Caused by Burkholderia pseudomallei (Melioidosis)
PLOS Neglected Tropical Diseases: published August 31, 2010 | https://doi.org/10.1371/journal.pntd.0000806
Metabolic Changes Reveal the Development of Schistosomiasis in Mice
PLOS Neglected Tropical Diseases: published August 31, 2010 | https://doi.org/10.1371/journal.pntd.0000807
A Simple Colorimetric Assay for Specific Detection of Glutathione-S Transferase Activity Associated with DDT Resistance in Mosquitoes
PLOS Neglected Tropical Diseases: published August 31, 2010 | https://doi.org/10.1371/journal.pntd.0000808
Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection
PLOS Neglected Tropical Diseases: published August 31, 2010 | https://doi.org/10.1371/journal.pntd.0000809
Functional Genome Annotation by Combined Analysis across Microarray Studies of Trypanosoma brucei
PLOS Neglected Tropical Diseases: published August 31, 2010 | https://doi.org/10.1371/journal.pntd.0000810
Multi-Country Evaluation of the Sensitivity and Specificity of Two Commercially-Available NS1 ELISA Assays for Dengue Diagnosis
PLOS Neglected Tropical Diseases: published August 31, 2010 | https://doi.org/10.1371/journal.pntd.0000811
The Onchocerca volvulus Cysteine Proteinase Inhibitor, Ov-CPI-2, Is a Target of Protective Antibody Response That Increases with Age
PLOS Neglected Tropical Diseases: published August 24, 2010 | https://doi.org/10.1371/journal.pntd.0000800
Establishment of Fruit Bat Cells (Rousettus aegyptiacus) as a Model System for the Investigation of Filoviral Infection
PLOS Neglected Tropical Diseases: published August 24, 2010 | https://doi.org/10.1371/journal.pntd.0000802
Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1
PLOS Neglected Tropical Diseases: published August 24, 2010 | https://doi.org/10.1371/journal.pntd.0000803
Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach
PLOS Neglected Tropical Diseases: published August 24, 2010 | https://doi.org/10.1371/journal.pntd.0000804
Neurocysticercosis, a Persisting Health Problem in Mexico
PLOS Neglected Tropical Diseases: published August 24, 2010 | https://doi.org/10.1371/journal.pntd.0000805
piggybac- and PhiC31-Mediated Genetic Transformation of the Asian Tiger Mosquito, Aedes albopictus (Skuse)
PLOS Neglected Tropical Diseases: published August 17, 2010 | https://doi.org/10.1371/journal.pntd.0000788
Interactions between Global Health Initiatives and Country Health Systems: The Case of a Neglected Tropical Diseases Control Program in Mali
PLOS Neglected Tropical Diseases: published August 17, 2010 | https://doi.org/10.1371/journal.pntd.0000798
Targeting Trachoma Control through Risk Mapping: The Example of Southern Sudan
PLOS Neglected Tropical Diseases: published August 17, 2010 | https://doi.org/10.1371/journal.pntd.0000799
The Echinococcus granulosus Antigen B Gene Family Comprises at Least 10 Unique Genes in Five Subclasses Which Are Differentially Expressed
PLOS Neglected Tropical Diseases: published August 10, 2010 | https://doi.org/10.1371/journal.pntd.0000784
A Randomized Controlled Trial of Chloroquine for the Treatment of Dengue in Vietnamese Adults
PLOS Neglected Tropical Diseases: published August 10, 2010 | https://doi.org/10.1371/journal.pntd.0000785
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