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Table of Contents

October 2008

Cover

Dengue virus is unable to productively infect dermal-type macrophages.

Issue Image

The image shows a human CD209+ macrophage, in which the dengue virus envelope E protein, fused to green fluorescent protein, is not co-localized with the acidic (red) perinuclear compartments. Envelope acidification is critical to initiate the viral life cycle. IL-10, present in the human skin, is required for the formation of these macrophages. Understanding these infection events shortly after the mosquito bite can help explain why many dengue infections are asymptomatic (see Kwan et al., doi:10.1371/journal.pntd.0000311).

Image Credit: Marion Decossas, Erika Navarro-Sanchez, and Hélène Dumortier

Editorial

The CNCDs and the NTDs: Blurring the Lines Dividing Noncommunicable and Communicable Chronic Diseases

Peter J. Hotez, Abdallah S. Daar

PLOS Neglected Tropical Diseases: published October 29, 2008 | https://doi.org/10.1371/journal.pntd.0000312

Viewpoints

Leishmaniases' Burden of Disease: Ways Forward for Getting from Speculation to Reality

Richard Reithinger

PLOS Neglected Tropical Diseases: published October 29, 2008 | https://doi.org/10.1371/journal.pntd.0000285

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  1. Marring Leishmaniasis: The Stigmatization and the Impact of Cutaneous Leishmaniasis in Pakistan and Afghanistan
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Symposium

Marring Leishmaniasis: The Stigmatization and the Impact of Cutaneous Leishmaniasis in Pakistan and Afghanistan

Masoom Kassi, Mahwash Kassi, Abaseen Khan Afghan, Rabeea Rehman, Pashtoon Murtaza Kasi

PLOS Neglected Tropical Diseases: published October 29, 2008 | https://doi.org/10.1371/journal.pntd.0000259

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Review

Complexities of Assessing the Disease Burden Attributable to Leishmaniasis

Caryn Bern, James H. Maguire, Jorge Alvar

PLOS Neglected Tropical Diseases: published October 29, 2008 | https://doi.org/10.1371/journal.pntd.0000313

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Research Articles

The Potential Impact of Density Dependent Fecundity on the Use of the Faecal Egg Count Reduction Test for Detecting Drug Resistance in Human Hookworms

Andrew C. Kotze, Steven R. Kopp

PLOS Neglected Tropical Diseases: published October 1, 2008 | https://doi.org/10.1371/journal.pntd.0000297

Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome

Nguyen Thi Phuong Lan, Mihoko Kikuchi, Vu Thi Que Huong, Do Quang Ha, Tran Thi Thuy, Vo Dinh Tham, Ha Manh Tuan, Vo Van Tuong, Cao Thi Phi Nga, Tran Van Dat, Toshifumi Oyama, Kouichi Morita, Michio Yasunami, Kenji Hirayama

PLOS Neglected Tropical Diseases: published October 1, 2008 | https://doi.org/10.1371/journal.pntd.0000304

Schistosoma mansoni Tegument Protein Sm29 Is Able to Induce a Th1-Type of Immune Response and Protection against Parasite Infection

Fernanda C. Cardoso, Gilson C. Macedo, Elisandra Gava, Gregory T. Kitten, Vitor L. Mati, Alan L. de Melo, Marcelo V. Caliari, Giulliana T. Almeida, Thiago M. Venancio, Sergio Verjovski-Almeida, Sergio C. Oliveira

PLOS Neglected Tropical Diseases: published October 1, 2008 | https://doi.org/10.1371/journal.pntd.0000308

Dermal-Type Macrophages Expressing CD209/DC-SIGN Show Inherent Resistance to Dengue Virus Growth

Wing-Hong Kwan, Erika Navarro-Sanchez, Hélène Dumortier, Marion Decossas, Hortense Vachon, Flavia Barreto dos Santos, Hervé W. Fridman, Félix A. Rey, Eva Harris, Philippe Despres, Christopher G. Mueller

PLOS Neglected Tropical Diseases: published October 1, 2008 | https://doi.org/10.1371/journal.pntd.0000311

High Throughput Selection of Effective Serodiagnostics for Trypanosoma cruzi infection

Gretchen Cooley, R. Drew Etheridge, Courtney Boehlke, Becky Bundy, D. Brent Weatherly, Todd Minning, Matthew Haney, Miriam Postan, Susana Laucella, Rick L. Tarleton

PLOS Neglected Tropical Diseases: published October 8, 2008 | https://doi.org/10.1371/journal.pntd.0000316

The Global Programme to Eliminate Lymphatic Filariasis: Health Impact after 8 Years

Eric A. Ottesen, Pamela J. Hooper, Mark Bradley, Gautam Biswas

PLOS Neglected Tropical Diseases: published October 8, 2008 | https://doi.org/10.1371/journal.pntd.0000317

Effects of Bothrops asper Snake Venom on Lymphatic Vessels: Insights into a Hidden Aspect of Envenomation

Javier Mora, Rodrigo Mora, Bruno Lomonte, José María Gutiérrez

PLOS Neglected Tropical Diseases: published October 15, 2008 | https://doi.org/10.1371/journal.pntd.0000318

“It Is Me Who Endures but My Family That Suffers”: Social Isolation as a Consequence of the Household Cost Burden of Buruli Ulcer Free of Charge Hospital Treatment

Koen Peeters Grietens, Alphonse Um Boock, Hans Peeters, Susanna Hausmann-Muela, Elizabeth Toomer, Joan Muela Ribera

PLOS Neglected Tropical Diseases: published October 15, 2008 | https://doi.org/10.1371/journal.pntd.0000321

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  1. Correction: “It Is Me Who Endures but My Family That Suffers”: Social Isolation as a Consequence of the Household Cost Burden of Buruli Ulcer Free of Charge Hospital Treatment
  2. Correction: “It Is Me Who Endures but My Family That Suffers”: Social Isolation as a Consequence of the Household Cost Burden of Buruli Ulcer Free of Charge Hospital Treatment

Tribendimidine and Albendazole for Treating Soil-Transmitted Helminths, Strongyloides stercoralis and Taenia spp.: Open-Label Randomized Trial

Peter Steinmann, Xiao-Nong Zhou, Zun-Wei Du, Jin-Yong Jiang, Shu-Hua Xiao, Zhong-Xing Wu, Hui Zhou, Jürg Utzinger

PLOS Neglected Tropical Diseases: published October 15, 2008 | https://doi.org/10.1371/journal.pntd.0000322

Web-Based Virtual Microscopy for Parasitology: A Novel Tool for Education and Quality Assurance

Ewert Linder, Mikael Lundin, Cecilia Thors, Marianne Lebbad, Jadwiga Winiecka-Krusnell, Heikki Helin, Byron Leiva, Jorma Isola, Johan Lundin

PLOS Neglected Tropical Diseases: published October 22, 2008 | https://doi.org/10.1371/journal.pntd.0000315

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  1. Correction: Web-Based Virtual Microscopy for Parasitology: A Novel Tool for Education and Quality Assurance

Use of Genomic DNA as an Indirect Reference for Identifying Gender-Associated Transcripts in Morphologically Identical, but Chromosomally Distinct, Schistosoma mansoni Cercariae

Jennifer M. Fitzpatrick, Anna V. Protasio, Andrew J. McArdle, Gary A. Williams, David A. Johnston, Karl F. Hoffmann

PLOS Neglected Tropical Diseases: published October 22, 2008 | https://doi.org/10.1371/journal.pntd.0000323

Controlling Tungiasis in an Impoverished Community: An Intervention Study

Daniel Pilger, Stefan Schwalfenberg, Jörg Heukelbach, Lars Witt, Norbert Mencke, Adak Khakban, Hermann Feldmeier

PLOS Neglected Tropical Diseases: published October 22, 2008 | https://doi.org/10.1371/journal.pntd.0000324

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

Hui Hong, Emmanuelle Coutanceau, Marion Leclerc, Laxmee Caleechurn, Peter F. Leadlay, Caroline Demangel

PLOS Neglected Tropical Diseases: published October 22, 2008 | https://doi.org/10.1371/journal.pntd.0000325

Stage- and Gender-Specific Proteomic Analysis of Brugia malayi Excretory-Secretory Products

Yovany Moreno, Timothy G. Geary

PLOS Neglected Tropical Diseases: published October 29, 2008 | https://doi.org/10.1371/journal.pntd.0000326

A Simple Scoring System to Differentiate between Relapse and Re-Infection in Patients with Recurrent Melioidosis

Direk Limmathurotsakul, Wipada Chaowagul, Narisara Chantratita, Vanaporn Wuthiekanun, Mayurachat Biaklang, Sarinna Tumapa, Nicholas J. White, Nicholas P. J. Day, Sharon J. Peacock

PLOS Neglected Tropical Diseases: published October 29, 2008 | https://doi.org/10.1371/journal.pntd.0000327