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Table of Contents: May 2008

Photograph showing an adult specimen of Triatoma dimidiata from Colombia. DNA sequences prove that this vector species has followed different evolutionary lines throughout its geographical distribution in Mexico, Guatemala, Honduras, Nicaragua, Panama, Colombia, and Ecuador. Speciation and subspeciation furnish a new frame to take into account for future control strategies (see Bargues et al., doi:10.1371/journal.pntd.0000233).

Image Credit: Image generated by Felipe Guhl.

Viewpoints

Policy Platform

Pentamidine Dosage: A Base/Salt Confusion

Thomas P. C. Dorlo, Piet A. Kager

Symposiums

Stigma and the Social Burden of Neglected Tropical Diseases

Mitchell G. Weiss

Research Articles

Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction

Elizabeth A. Misch, Murdo Macdonald, Chaman Ranjit, Bishwa R. Sapkota, Richard D. Wells, M. Ruby Siddiqui, Gilla Kaplan, Thomas R. Hawn

Phylogeography and Genetic Variation of Triatoma dimidiata, the Main Chagas Disease Vector in Central America, and Its Position within the Genus Triatoma

María Dolores Bargues, Debora R. Klisiowicz, Fernando Gonzalez-Candelas, Janine M. Ramsey, Carlota Monroy, Carlos Ponce, Paz María Salazar-Schettino, Francisco Panzera, Fernando Abad-Franch, Octavio E. Sousa, Christopher J. Schofield, Jean Pierre Dujardin, Felipe Guhl, Santiago Mas-Coma

Neglected Diseases in the News: A Content Analysis of Recent International Media Coverage Focussing on Leishmaniasis and Trypanosomiasis

Mangai Balasegaram, Sooria Balasegaram, Denis Malvy, Pascal Millet

Age-Related Alteration of Arginase Activity Impacts on Severity of Leishmaniasis

Ingrid Müller, Asrat Hailu, Beak-San Choi, Tamrat Abebe, Jose M. Fuentes, Markus Munder, Manuel Modolell, Pascale Kropf

The Effect of Azithromycin on Ivermectin Pharmacokinetics—A Population Pharmacokinetic Model Analysis

Ahmed El-Tahtawy, Paul Glue, Emma N. Andrews, Jack Mardekian, Guy W. Amsden, Charles A. Knirsch

Trypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human African Trypanosomiasis

John K. Thuita, John M. Kagira, David Mwangangi, Enock Matovu, C. M. R. Turner, Daniel Masiga

Altered Patterns of Gene Expression Underlying the Enhanced Immunogenicity of Radiation-Attenuated Schistosomes

Gary P. Dillon, Theresa Feltwell, Jason Skelton, Patricia S. Coulson, R. Alan Wilson, Alasdair C. Ivens

Controlling Schistosomiasis: Significant Decrease of Anaemia Prevalence One Year after a Single Dose of Praziquantel in Nigerien Schoolchildren

Zilahatou B. Tohon, Halima B. Mainassara, Amadou Garba, Ali E. Mahamane, Elisa Bosqué-Oliva, Maman-Laminou Ibrahim, Jean-Bernard Duchemin, Suzanne Chanteau, Pascal Boisier

High Levels of Genetic Differentiation between Ugandan Glossina fuscipes fuscipes Populations Separated by Lake Kyoga

Patrick P. Abila, Michel A. Slotman, Aristeidis Parmakelis, Kirstin B. Dion, Alan S. Robinson, Vincent B. Muwanika, John C. K. Enyaru, Loyce M. Lokedi, Serap Aksoy, Adalgisa Caccone

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