Advertisement
  • Loading metrics

Neglected Tropical Diseases in the Anthropocene: The Cases of Zika, Ebola, and Other Infections

  • Peter J. Hotez

    hotez@bcm.edu

    Affiliations Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America, Sabin Vaccine Institute and Texas Children’s Hospital Center for Vaccine Development, Houston, Texas, United States of America, James A. Baker III Institute for Public Policy, Rice University, Houston, Texas, United States of America, Department of Biology, Baylor University, Waco, Texas, United States of America

Neglected Tropical Diseases in the Anthropocene: The Cases of Zika, Ebola, and Other Infections

  • Peter J. Hotez
PLOS
x

While we advance through a geological epoch that increasingly reflects human intervention on a massive scale, we might expect to see the continued expansion of epidemic neglected tropical diseases, as we have recently seen for Zika and Ebola virus infections.

Emerging evidence indicates that the Holocene, our most recent geological epoch that began at the end of the last ice age almost 12,000 years ago, has undergone some fundamental changes because of human activity. Since the origins of agriculture and deforestation and later accelerating with the industrial revolution, followed by rapid 20th century population growth extending into the nuclear age, our planet has undergone a fundamental and seemingly irreversible geological shift [1]. According to many (but not all) prominent Earth scientists, humans have profoundly altered the planet, thereby ushering in a new and so-called Anthropocene epoch (Fig 1).

In a January 2016 article in Science, Colin Waters from the British Geological Survey and his colleagues provide important geochemical evidence to support designating the end of the Holocene as the Anthropocene [1]. It includes data showing increasing lead levels after World War II, altered soil nitrogen and phosphorous levels because of increased fertilizer use, and the appearance of newly created radionuclides, beginning with the atomic bomb tests in the New Mexico desert at Los Alamos [1]. Alongside these human-induced geochemical signatures are elevated carbon dioxide and methane levels and sharp increases in average global temperatures [1].

Levels of concrete and plastic have also dramatically increased in recent years, while in parallel, there has been massive loss of animal and plant species [2]. Species extinctions have reached unprecedented levels [1,3].

In this late Anthropocene epoch, we have seen significant increases in the incidence or prevalence rates of several neglected tropical diseases (NTDs), due partly or mostly to human-induced changes to our planet. This is especially true for NTDs transmitted by invertebrate vectors, including mosquitoes, kissing bugs, and snails, as well as highly lethal zoonotic virus infections from bats and other mammals. For example, in the Americas, dengue fever reemerged in the 1980s, while chikungunya and Zika virus infections have aggressively spread across the Latin American and Caribbean region. Venezuela in particular has seen dramatic increases in malaria and most of its neglected tropical diseases (NTDs), including Chagas disease, schistosomiasis, and Zika virus infection, for which unprecedented urban foci are also occurring [4]. Across the Atlantic Ocean, Southern Europe has of late seen the emergence or reemergence of malaria in Greece, West Nile virus infection and chikungunya in Italy and Spain, dengue in Portugal, and schistosomiasis on the French island of Corsica [5]. The Middle East and North Africa (MENA) region is now considered one of the worst-affected global hotspots for NTDs and other emerging infections such as leishmaniasis, schistosomiasis, and MERS coronavirus infection; measles and polio have also returned [6]. Ebola caused thousands of deaths and overwhelmed the health systems of Guinea, Liberia, and Sierra Leone in West Africa in 2014–2015 [7], while East Africa and the Sahel are considered among the most important regions for kala-azar and multiple other NTDs [8]. Schistosomiasis continues to increase throughout Africa, where it is now a major cofactor in its AIDS epidemic [9]. Southeast Asia has seen the rise of Nipah and Hendra virus from bats, in addition to drug resistant malaria, enterovirus 71, melioidosis, and foodborne trematodiases transmitted by snails [10].

Several human activities that characterize the Anthropocene account for the increases in NTDs. It is instructive to see how some of these factors illustrated in Fig 2 helped to facilitate the emergence of two of the most devastating NTDs in 2014 and 2015—Ebola and Zika virus infections, respectively, as well as other high-disease-burden NTDs such as the cutaneous and visceral forms of leishmaniasis and schistosomiasis.

thumbnail
Fig 2. The major forces arising out of the Anthropocene now promoting the emergence of catastrophic neglected tropical diseases (NTDs).

https://doi.org/10.1371/journal.pntd.0004648.g002

Poverty and Blue Marble Health

As has been said very frequently in our editorials, poverty is front and center. NTDs are most common in the setting of poverty [11,12], while simultaneously helping to perpetuate poverty through their long-standing negative effects on maternal and child health and human productivity and labor [13,14]. Ebola has so far emerged almost exclusively in impoverished nations such as the Democratic Republic of Congo or Guinea, Liberia, and Sierra Leone, while Zika is disproportionately affecting impoverished areas such as Brazil’s poorest northeastern provinces. In the case of Zika or other vector-borne NTDs such as leishmaniasis and Chagas disease, poverty equates to poor quality housing, in addition to uncollected garbage and standing water in poor neighborhoods that allow certain insects to breed nearby. For these reasons, we might expect poor countries such as Haiti or Jamaica to suffer greatly from the advance of Zika in the Caribbean region.

Yet another feature of Zika, leishmaniasis, Chagas disease, and other NTDs are their propensity to strike the poorest people who live in the wealthier group of 20 countries, such as Brazil or Mexico. The concept of “blue marble health” has been invoked to describe the surprising disease burden of NTDs among the poor living in these countries [15]. Today, most of the world’s NTDs paradoxically occur in the world’s largest economies, but mostly among the disenfranchised poor in those nations [15].

Political Destabilization, Conflict, and Post-conflict

Next to poverty, these forces may account for the largest risk factor for NTDs [6,16,17]. The long-standing atrocities and civil and international conflicts decimated the health systems of Guinea, Liberia, and Sierra Leone, thereby allowing Ebola and Lassa fever to flourish [7,17], while these same forces facilitated the rapid spread and lethality of human African trypanosomiasis and kala-azar in Africa [8,18]. Conflict and post-conflict settings are central to the massive epidemic of cutaneous leishmaniasis in the Middle East [6]. While Zika has so far not been linked to these factors, the political destabilization in Venezuela could become a contributory factor.

Deforestation

In Asia, deforestation may have increased human and bat contact to promote Nipah and Hendra viruses and SARS [10]. Deforestation is also an important factor promoting the expansion of vector borne NTDs, including leishmaniasis [19]. Deforestation has been noted to have some possible links with the emergence of Ebola [20]. For instance, the Guinea forest region where Ebola emerged in 2014 has been severely and adversely affected by clear-cut logging [7].

Dams

Bodies of fresh water arising from large-scale hydroelectric projects can help aquatic snails to proliferate, including those that transmit schistosomiasis in Africa and foodborne trematodiases in Asia. Dams and newly formed reservoirs of fresh water also create mosquito breeding sites for arbovirus infections and malaria and also facilitate waterborne intestinal infections [21]. In China, on the other hand, the Three Gorges Dam on the Yangtze River has assisted flood control and so far has not been shown to promote the emergence of Schistosoma japonicum infection [22].

Urbanization and Human Migrations

The large-scale movement of human populations into cities can create crowded conditions, which together with destruction of the environment favor arthropod vectors [23], including the Aedes aegypti mosquito that transmits Zika, dengue, chikungunya, and yellow fever. Accelerated urbanization that outpaces sanitation and sewage control infrastructures is also a key factor in the endemicity of leptospirosis and enteric NTDs [24,25]. Overall, human migrations of immunologically naïve populations to endemic regions have accounted for rapid spread of infections, as well as the converse—infected populations introducing new diseases. The 2014 Brazilian FIFA World Cup soccer games may have been a factor in bringing Asian populations with Zika into areas where Aedes aegypti is found, although this hypothesis has since been dismissed [26]. However, the annual Hajj, the Muslim pilgrimage to Mecca that brings millions of people to Saudi Arabia, has also been postulated as having helped introduce dengue [27,28], as it could Zika virus infection in 2016 or 2017. The Hajj has also had a role in the emergence of meningococcal disease and other acute respiratory infections [29,30].

Climate Change and El Niño Events

Major climate change events in the Anthropocene include increased temperatures and altered rainfall patterns that expand arthropod vector habitats and ranges. Such factors could be responsible for accelerating the geographic expansions of arbovirus infections [31,32], leishmaniasis [33], and Chagas disease [34], but this concept requires further exploration. In addition, we are just beginning to understand the role of El Niño events in promoting these and other NTDs [35,36]. The fact that Zika virus expanded dramatically in an El Niño year is also of interest, but as yet, there are no proven links.

Many of the factors highlighted above were either manufactured or shaped by human activity. The dramatic expansions in the number of cases of arbovirus infections caused by dengue, chikungunya, and now Zika in recent years, together with a recent explosive Ebola outbreak in 2014–2015, give us pause to evaluate human influence on the biosphere and to recognize that beyond globalization, the Anthropocene could become a dominant theme for spreading NTDs or creating catastrophic human epidemics in the years to come.

References

  1. 1. Waters CN, Zalasiewicz J, Summerhayes C, Barnofsky AD, Poirier C, et al (2016) The Anthropocene is functionally and stratigraphically distinct from the Holocene. Science 351 (6269): 137
  2. 2. Vaughan A (2016) Human impact has pushed earth into the Anthropocene, scientists say. The Guardian, January 7, http://www.theguardian.com/environment/2016/jan/07/human-impact-has-pushed-earth-into-the-anthropocene-scientists-say, accessed March 25, 2016.
  3. 3. Wilson EO (2016) Half-Earth: Our Planet’s Fight for Life. Liveright, 272 p.
  4. 4. Hotez PJ, Herricks J (2014) Venezuela: an emerging tropical disease and humanitarian emergency? PLOS Speaking of Medicine, August 26
  5. 5. Hotez PJ (2016) Southern Europe’s coming plagues: vector-borne neglected tropical diseases. PLoS Negl Trop Dis 10: in press.
  6. 6. Hotez PJ (2015) Vaccine Science Diplomacy: Expanding Capacity to Prevent Emerging and Neglected Tropical Diseases Arising from Islamic State (IS)–Held Territories. PLoS Negl Trop Dis 9(9): e0003852. pmid:26402466
  7. 7. Bausch DG, Schwarz L (2014) Outbreak of Ebola Virus Disease in Guinea: Where Ecology Meets Economy. PLoS Negl Trop Dis 8(7): e3056. pmid:25079231
  8. 8. Diro E, Lynen L, Ritmeijer K, Boelaert M, Hailu A, van Griensven J (2014) Visceral Leishmaniasis and HIV Coinfection in East Africa. PLoS Negl Trop Dis 8(6): e2869. pmid:24968313
  9. 9. Mbabazi PS, Andan O, Fitzgerald DW, Chitsulo L, Engels D, Downs JA (2011) Examining the Relationship between Urogenital Schistosomiasis and HIV Infection. PLoS Negl Trop Dis 5(12): e1396. pmid:22163056
  10. 10. Hotez PJ, Bottazzi ME, Strych U, Chang L-Y, Lim YAL, Goodenow MM, et al. (2015) Neglected Tropical Diseases among the Association of Southeast Asian Nations (ASEAN): Overview and Update. PLoS Negl Trop Dis 9(4): e0003575. pmid:25880767
  11. 11. Fallah MP, Skrip LA, Gertler S, Yamin D, Galvani AP (2015) Quantifying Poverty as a Driver of Ebola Transmission. PLoS Negl Trop Dis 9(12): e0004260. pmid:26720278
  12. 12. Habtamu E, Wondie T, Aweke S, Tadesse Z, Zerihun M, Zewdie Z, et al. (2015) Trachoma and Relative Poverty: A Case-Control Study. PLoS Negl Trop Dis 9(11): e0004228. pmid:26600211
  13. 13. Hotez PJ, Ferris MT. The antipoverty vaccines. Vaccine. 2006 Jul 26;24(31–32):5787–99. Epub 2006 May 17. pmid:16759763
  14. 14. Hotez PJ, Fenwick A, Savioli L, Molyneux DH. Rescuing the bottom billion through control of neglected tropical diseases. Lancet. 2009 May 2;373(9674):1570–5. pmid:19410718
  15. 15. Hotez PJ (2013) NTDs V.2.0: “Blue Marble Health”—Neglected Tropical Disease Control and Elimination in a Shifting Health Policy Landscape. PLoS Negl Trop Dis 7(11): e2570. pmid:24278496
  16. 16. Fürst T, Raso G, Acka CA, Tschannen AB, N'Goran EK, Utzinger J (2009) Dynamics of Socioeconomic Risk Factors for Neglected Tropical Diseases and Malaria in an Armed Conflict. PLoS Negl Trop Dis 3(9): e513. pmid:19907632
  17. 17. Shaffer JG, Grant DS, Schieffelin JS, Boisen ML, Goba A, Hartnett JN, et al. (2014) Lassa Fever in Post-Conflict Sierra Leone. PLoS Negl Trop Dis 8(3): e2748. pmid:24651047
  18. 18. Hotez PJ (2015) Combating the next lethal epidemic. Science 348(6232):296–7.
  19. 19. Chaves LF, Cohen JM, Pascual M, Wilson ML (2008) Social Exclusion Modifies Climate and Deforestation Impacts on a Vector-Borne Disease. PLoS Negl Trop Dis 2(2): e176.
  20. 20. Agoramoorthy G, Chakraborty C (2014) Ebola eradication may need wider partnership. CMAJ 186(15):1170
  21. 21. Ziegler AD, Petney TN, Grundy-Warr C, Andrews RH, Baird IG, Wasson RJ, et al. (2013) Dams and Disease Triggers on the Lower Mekong River. PLoS Negl Trop Dis 7(6): e2166. pmid:23853695
  22. 22. Gray DJ, Thrift AP, Williams GM, Zheng F, Li Y- S, Guo J, et al. (2012) Five-Year Longitudinal Assessment of the Downstream Impact on Schistosomiasis Transmission following Closure of the Three Gorges Dam. PLoS Negl Trop Dis 6(4): e1588 pmid:22506083
  23. 23. Stoddard ST, Morrison AC, Vazquez-Prokopec GM, Paz Soldan V, Kochel TJ, Kitron U, et al. (2009) The Role of Human Movement in the Transmission of Vector-Borne Pathogens. PLoS Negl Trop Dis 3(7): e481 pmid:19621090
  24. 24. Maciel EAP, de Carvalho ALF, Nascimento SF, de Matos RB, Gouveia EL, Reis MG, et al. (2008) Household Transmission of Leptospira Infection in Urban Slum Communities. PLoS Negl Trop Dis 2(1): e154. pmid:18357340
  25. 25. Akullian A, Ng’eno E, Matheson AI, Cosmas L, Macharia D, Fields B, et al. (2015) Environmental Transmission of Typhoid Fever in an Urban Slum. PLoS Negl Trop Dis 9(12): e0004212. pmid:26633656
  26. 26. Faria NR, Azevedo RSS, Kraemer MUG, Souza R, Cunha MS, et al. Zika virus in the Americas: Early epidemiological and genetic findings. Science. 2016 Mar 24. pii: aaf5036. [Epub ahead of print]
  27. 27. Azhar EI, Hashem AM, El-Kafrawy SA, Abol-Ela S, Abd-Alla AM, Sohrab SS, Farraj SA, Othman NA, Ben-Helaby HG, Ashshi A, Madani TA, Jamjoom G (2015) Complete genome sequencing and phylogenetic analysis of dengue type 1 virus isolated from Jeddah, Saudi Arabia. Virol J. 2015 Jan 16;12:1. pmid:25591713
  28. 28. Aziz AT, Al-Shami SA, Mahyoub JA, Hatabbi M, Ahmad AH, Rawi CS (2014) An update on the incidence of dengue gaining strength in Saudi Arabia and current control approaches for its vector mosquito. Parasit Vectors. 7:258. pmid:24890567
  29. 29. Lingappa JR, Al-Rabeah AM, Haijeh R, Mustafa T, Fatani A, et al (2003) Serogroup W-135 meningococcal disease during the Hajj, 2000. Emerg Infect Dis 9(6): 665–71. pmid:12781005
  30. 30. Gautret P, Soula G, Parola P, Brouqui P (2009) Hajj pilgrims’ knowledge about acute respiratory infections. Emerg Infect Dis 15(11): 1861–2. pmid:19891890
  31. 31. Colón-González FJ, Fezzi C, Lake IR, Hunter PR (2013) The Effects of Weather and Climate Change on Dengue. PLoS Negl Trop Dis 7(11): e2503. pmid:24244765
  32. 32. Beebe NW, Cooper RD, Mottram P, Sweeney AW (2009) Australia's Dengue Risk Driven by Human Adaptation to Climate Change. PLoS Negl Trop Dis 3(5): e429. pmid:19415109
  33. 33. Fischer D, Moeller P, Thomas SM, Naucke TJ, Beierkuhnlein C (2011) Combining Climatic Projections and Dispersal Ability: A Method for Estimating the Responses of Sandfly Vector Species to Climate Change. PLoS Negl Trop Dis 5(11): e1407. pmid:22140590
  34. 34. Garza M, Feria Arroyo TP, Casillas EA, Sanchez-Cordero V, Rivaldi C-L, Sarkar S (2014) Projected Future Distributions of Vectors of Trypanosoma cruzi in North America under Climate Change Scenarios. PLoS Negl Trop Dis 8(5): e2818. pmid:24831117
  35. 35. Chaves LF, Calzada JE, Valderrama A, Saldaña A (2014) Cutaneous Leishmaniasis and Sand Fly Fluctuations Are Associated with El Niño in Panamá. PLoS Negl Trop Dis 8(10): e3210. pmid:25275503
  36. 36. Weinberger D, Baroux N, Grangeon J-P, Ko AI, Goarant C (2014) El Niño Southern Oscillation and Leptospirosis Outbreaks in New Caledonia. PLoS Negl Trop Dis 8(4): e2798. pmid:24743322