Citation: Rimoin AW, Hotez PJ (2013) NTDs in the Heart of Darkness: The Democratic Republic of Congo's Unknown Burden of Neglected Tropical Diseases. PLoS Negl Trop Dis 7(7): e2118. doi:10.1371/journal.pntd.0002118
Published: July 25, 2013
Copyright: © 2013 Rimoin, Hotez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: The authors received no specific funding for this article.
Competing interests: The authors have declared that no competing interests exist.
Anne Rimoin, PhD, is an Associate Professor in the Department of Epidemiology, UCLA School of Public Health. Peter J. Hotez, MD, PhD, is Co-Editor-in-Chief of PLOS Neglected Tropical Diseases. He is Dean of the National School of Tropical Medicine at Baylor College of Medicine, President of the Sabin Vaccine Institute, Professor and Head of the Section of Pediatric Tropical Medicine in the Department of Pediatrics at Texas Children’s Hospital and Baylor College of Medicine, Texas Children’s Hospital Endowed Chair in Tropical Pediatrics, and Baker Institute Fellow in Disease and Poverty, Houston, Texas, United States of America.
The Democratic Republic of Congo may have one of the world's highest burdens of neglected tropical diseases, but nationwide there is a dearth of surveillance activities and available epidemiologic data about these conditions.
The Democratic Republic of Congo (DR Congo) is a vast nation of almost one million square miles (about the size of Greenland or one-quarter the size of the United States, and the second largest country in Africa) and more than 70 million people located in the heart of Africa (Figure 1). For at least the last hundred years, the neglected tropical diseases (NTDs) have made a significant impact on the history of the Congo Basin. Despite a navigable river system, early European attempts to explore the Belgian Congo during the nineteenth and early twentieth centuries were blocked because of the high prevalence of human African trypanosomiasis (HAT) and other NTDs . Indeed, the horrific effects of epidemic sleeping sickness were described in detail by Joseph Conrad in Heart of Darkness .
From CIA Factbook, https://www.cia.gov/library/publications/the-world-factbook/maps/cg_largelocator_template.html, accessed December 31, 2012.
When it was known as Zaire during the last quarter of the twentieth century, the resulting dissolution of health systems and public health infrastructure contributed to the reemergence of HAT . In 1998, the year following the overthrow of Mobutu Sese Seko, the number of reported cases peaked at 26,000 (the highest in the world) . Even today, the DR Congo has the greatest number of cases of HAT anywhere in Africa and worldwide , , as the nation has yet to recover from years of conflict, extreme violence, and massive human migrations .
Beyond sleeping sickness, the decades of conflict and breakdowns in health infrastructure have contributed to the high prevalence of several major NTDs , although paradoxically conflict may not be a significant factor in the emergence of malaria and HIV/AIDS in DR Congo , . In Table 1 we attempted to summarize the limited information currently available for the DR Congo. Our best information to date suggests that DR Congo may have the largest number of leprosy cases in Africa, and possibly the second or third highest number of cases of several high-prevalence NTDs, including intestinal helminth infections, lymphatic filariasis, and schistosomiasis , . Because of its huge jungle population of nonhuman primates and other potential and actual animal reservoir hosts, the DR Congo is also believed to be the origin of several important emerging viruses of humans. According to some investigators, human HIV/AIDS first emerged in DR Congo , , as did strains of Chikungunya virus , Crimean-Congo hemorrhagic fever (CCHF, ), Ebola virus , monkeypox , and a novel rhabdovirus (Bas-Congo virus) .
Despite the public health importance of DR Congo's NTDs, there is much more that we do not know than we do know about both the high-prevalence NTDs and the emerging viruses in the Congo Basin. Shown in Figure 2 is a recent map of the distribution of African schistosomiasis survey locations published by Hürlimann et al. in PLOS Neglected Tropical Diseases in 2011 . More than 90% of the world's cases of schistosomiasis are currently found in sub-Saharan Africa. What is striking is the dearth of schistosomiasis surveillance activity in Central Africa and particularly in the DR Congo. A similar situation is also apparent for the soil-transmitted helminth infections. Shown in Figure 3 is a map from the Global Helminth Atlas of the distribution of ascariasis, trichuriasis, and hookworm in DR Congo . The map reveals a reasonable level of sampling at the mouth of the Congo River and near the capital, Kinshasa, but only a single surveillance site in the interior of the country—a country as vast as Greenland! Therefore most of our estimates for schistosomiasis and soil-transmitted helminthiases disease burdens in DR Congo are based on an extreme paucity of surveillance data, particularly active surveillance targeted to high-prevalence areas. Much the same is true for ongoing polio surveillance efforts in the country .
Map from Global Atlas of Helminth Infections, http://www.thiswormyworld.org/maps/democratic-republic-of-the-congo, accessed December 29, 2011.
The absence of NTD disease surveillance is itself a threat to the people of the DR Congo and indeed to global public health. Time and again DR Congo has shown us how this nation represents the cradle of a number of important emerging and reemerging viral infections –, including some with pandemic potential. Epidemic infections there have impeded polio elimination efforts just as they previously thwarted vaccine eradication campaigns for smallpox more than 30 years ago . The high prevalence rate of NTDs, together with emerging viral infections, suggests that DR Congo is also a key sentinel site to detect the emergence of important coinfections, such as HIV/AIDS and schistosomiasis .
There is an urgent need to implement a comprehensive program for disease active and targeted surveillance comprised of studies to examine the high-prevalence NTDs, including the major helminth infections (e.g., intestinal helminth infections, schistosomiasis, lymphatic filariasis, and onchocerciasis) and key protozoan and bacterial NTDs (e.g., intestinal protozoan infections and toxoplasmosis, leprosy, Buruli ulcer, and typhoidal and non-typhoidal salmonellosis) . While the Ministry of Public Health for the DR Congo deserves important credit for its key efforts to fight NTDs such as HAT, lymphatic filariasis, ochocerciasis, and schistosomiasis , they could be expanded and better supported by international donors. Equally important are studies to monitor the emergence of key viral infections, including arboviral infections (e.g., yellow fever, dengue, Chikungunya, and CCHF), filoviruses, poxviruses, rhabdoviruses, and retroviruses. Geographic information systems and remote sensing will become important tools for this expanded program targeting both the high-prevalence NTDs and emerging viruses , .
Studies by a number of investigators have demonstrated the feasibility of conducting high-level and sophisticated disease surveillance in DR Congo. While working there is challenging, as it is in many conflict and post-conflict sub-Saharan African countries, the Ministry of Public Health of DR Congo has time and time again demonstrated initiative and willingness to expand NTD disease surveillance and control activities. Indeed, through support of the United States Agency for International Development (USAID), DR Congo is poised to begin an ambitious program of NTD mapping and integrated disease control focused on mass drug administration for a number of its highest prevalence diseases . Implementation of an ambitious NTD control program in DR Congo portends exciting possibilities to reduce the prevalence and intensity of many of the high-prevalence NTDs there, thus making a huge impact on the burden of disease in sub-Saharan Africa. The World Health Organization and its regional office for Africa are also actively working with the DR Congo government to improve health through control of NTDs and other infections , while the Belgian Development Agency is actively committed to rural development . In parallel, there are equally compelling reasons to expand disease surveillance for the emerging viruses in DR Congo, which represent imminent threats to the populations of Africa and may ultimately exhibit pandemic potential . Expanded programs for health systems research strengthening and operational research are also urgently needed and would make an important contribution toward addressing the Millennium Development Goals.
- 1. Hotez PJ (2013) Forgotten people, forgotten diseases: the neglected tropical diseases and their impact on global health and development. 2nd edition. Washington: ASM Press. 275 p.
- 2. Conrad J (1902) Heart of Darkness and The Secret Sharer. New York: Signet Classics, Penguin Putnam. 184 p.
- 3. Simarro PP, Jannin J, Cattand P (2008) Eliminating human African trypanosomiasis: where do we stand and what comes next? PLoS Med 5: e55 doi:10.1371/journal.pmed.0050055.
- 4. World Health Organization (2006) Human African trypanosomiasis (sleeping sickness): epidemiological update. Wkly Epidemiol Rec 81: 71–80.
- 5. Mumba D, Bohorquez E, Messina J, Kande V, Taylor SM, et al. (2011) Prevalence of human African trypanosomiasis in the Democratic Republic of the Congo. PLoS Negl Trop Dis 5: e1246 doi:10.1371/journal.pntd.0001246.
- 6. Muyembe-Tamfum J-J, Mulembakani P, Lekie RB, Szczeniowski M, Jezek Z, et al. (2011) Smallpox and its eradication in the Democratic Republic of Congo: lessons learned. Vaccine 29 Suppl 4: D13–D16.
- 7. Messina JP, Taylor SM, Meshnick SR, Linke AM, Tshefu AK, et al. (2011) Population, behavioural and environmental drivers of malaria prevalence in the Democratic Republic of Congo. Malaria J 10: 161.
- 8. Spiegel PB, Bennedsen AR, Claass J, Bruns L, Patterson N, et al. (2007) Prevalence of HIV infectin in conflict-affected and displaced people in seven sub-Saharan African countries: a systematic review. Lancet 369: 2187–2195.
- 9. World Health Organization (2008) Global leprosy situation, beginning of 2008. Wkly Epidemiol Rec 83: 293–300.
- 10. Hotez PJ, Kamath A (2009) Neglected tropical diseases in sub-Saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis 3: e412 doi:10.1371/journal.pntd.0000412.
- 11. Vangroenweghe D (2001) The earliest cases of human immunodeficiency virus type 1 group M in Congo-Kinshasa, Rwanda and Burundi and the origin of acquired immune deficiency syndrome. Philos Trans R Soc Lond B Biol Sci 356: 923–925.
- 12. Pepin J (2011) The origins of AIDS. Cambridge: Cambridge University Press. 310 p.
- 13. Pastorino B, Muyembe-Tamfum JJ, Bessaud M, Tock F, Tolou H (2004) Epidemic resurgence of Chikungunya virus in Democratic Republic of the Congo: identification of a new central African strain. J Med Virol 74: 277–282.
- 14. Grard G, Drexler JF, Fair J, Muyembe J-J, Wolfe ND, et al. (2011) Re-emergence of Crimean-Congo hemorrhagic fever virus in Central Africa. PLoS Negl Trop Dis 5: e1350 doi:10.1371/journal.pntd.0001350.
- 15. Grard G, Biek R, Tamfum JJ, Fair J, Wolfe N, et al. (2011) Emergence of divergent Zaire ebola virus strains in Democratic Republic of the Congo in 2007 and 2008. J Infect Dis 204 Suppl 3: S776–S784.
- 16. Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, et al. (2010) Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A 107: 16262–16267.
- 17. Grard G, Fair JN, Lee D, Slikas E, Steffen I, et al. (2012) A novel rhabdovirus associated with acute hemorrhagic fever in Central Africa. PLoS Pathog 8: e1002924 doi:10.1371/journal.ppat.1002924.
- 18. Hürlimann E, Schur N, Boutsika K, Stensgaard A-S, Laserna de Himpsl M, et al. (2011) Toward an open-access global database for mapping, control, and surveillance of neglected tropical diseases. PLoS Negl Trop Dis 5: e1404 doi:10.1371/journal.pntd.0001404.
- 19. Global Atlas of Helminth Infections. Democratic Republic of the Congo. Available: http://www.thiswormyworld.org/maps/democratic-republic-of-the-congo. Accessed 29 December 2011.
- 20. Mbabazi PS, Andan O, Fitzgerald DW, Chitsulo L, Engels D, et al. (2011) Examining the relationship between urogenital schistosomiasis and HIV infection. PLoS Negl Trop Dis 5: e1396 doi:10.1371/journal.pntd.0001396.
- 21. République Démocratique du Congo Ministère de la Santé Publique. Program specialises. Available: http://www.minisanterdc.cd/new/index.php/sample-sites. Accessed 1 December 2012.
- 22. Brooker S, Clements ACA, Bundy DAP (2006) Global epidemiology, ecology and control of soil-transmitted helminth infections. Adv Parasitol 62: 221–261.
- 23. Fuller T, Thomassen HA, Mulembakani PM, Johnston SC, Lloy-Smith JO, et al. (2011) Using remote sensing to map the risk of human monkeypox virus in the Congo Basin. Ecohealth 8: 14–25.
- 24. USAID's NTD Program. Neglected tropical diseases in Democratic Republic of Congo. Available: http://www.neglecteddiseases.gov/countries/country_profiles/drc.html. Accessed 26 February 2012.
- 25. World Health Organization Regional Office for Africa. Democratic Republic of the Congo WHO country office. Available: http://www.afro.who.int/en/democratic-republic-of-congo/who-country-office-dem-rep-of-congo.html. Accessed 1 December 2012.
- 26. Belgian Development Agency. DR Congo. Available: http://www.btcctb.org/en/countries/dr-congo. Accessed 1 December 2012.
- 27. Wolfe N (2009) Preventing the next pandemic. Sci Am 300: 76–81.