Citation: Gerns HL, Sangaré LR, Walson JL (2012) Integration of Deworming into HIV Care and Treatment: A Neglected Opportunity. PLoS Negl Trop Dis 6(7): e1738. https://doi.org/10.1371/journal.pntd.0001738
Editor: Simon Brooker, London School of Hygiene & Tropical Medicine, United Kingdom
Published: July 31, 2012
Copyright: © Gerns et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This publication was made possible by Grant Number TL1 RR 025016 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and by the University of Washington Center for AIDS Research, Scientific Program on HIV and co-infections. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. The funders had no role in preparation of this manuscript.
Competing interests: The authors have declared that no competing interests exist.
In sub-Saharan Africa, where two-thirds of all HIV-infected individuals reside, many are now aware of their HIV infection status and millions are receiving antiretroviral therapy. In many countries in the region, new infections are declining and individuals are living longer with treatment to control their HIV infection. The infrastructure behind HIV care and treatment is vital in addressing the HIV pandemic, and similarly could be utilized to address and promote other health issues specific to persons living with HIV.
An estimated 2.1 million children are infected with HIV in sub-Saharan Africa, where multiple helminth species are also endemic . Likely half of these children are co-infected with helminths . The most recognized consequences of helminth infection in children include anemia, malnutrition, and impaired cognitive development, which are independent risk factors for death among HIV-infected children. Standard treatment of soil-transmitted helminth infection entails a single 400 mg dose of albendazole , making routine deworming of children a simple intervention that safely and affordably prevents the adverse effects of chronic helminth infection. Deworming HIV-infected children, specifically, may have a substantial impact on child health through the synergistic effects of improved nutritional status, greater control of other infectious diseases, and increased vaccine responsiveness, and therefore should be provided though HIV care services .
Helminth infection in HIV-infected children may impact how the host responds to infectious diseases and immunizations, indirectly through the pathway of malnutrition, as well as directly through immunologic mechanisms. Beyond nutritional deficits, helminths also induce immunosuppressive responses, creating an ideal environment for chronic helminth infection, and inhibiting the host's ability to control other diseases such as HIV , . Clinical studies suggest that deworming HIV-infected individuals may delay HIV progression, as measured by CD4 count and HIV viral load –. It is plausible that in addition to improving nutritional status, eliminating helminths in infected individuals may directly impact control of other infectious diseases such as HIV.
Helminth infection may also undermine the benefits of childhood immunizations, through malnutrition, and also by diminishing immune responses to vaccines, both at the time of vaccination and at disease exposure. Population-level data show that regional variations in vaccine efficacy correlate with variations in the prevalence of enteric pathogens . For example, rotavirus vaccine efficacy may be 50% higher in developed countries compared to Africa and Asia . Polio eradication efforts have also been challenged by diminished efficacy of the oral polio vaccine in India as compared to the rest of the world . While the distribution of soil-transmitted helminths represents only one of several factors contributing to these regional variations in vaccine responsiveness, it is a factor which can be easily targeted and controlled through routine deworming .
Individual-level evidence also suggests that helminth infection impacts immunologic responses to vaccines. Experimental human and animal studies have shown deworming before immunization increases protective antibody titers, while decreasing immuno-regulatory cytokines –. Children who failed to respond to oral poliovirus vaccination were 25% (p = 0.04) more likely to harbor infections with intestinal parasites than vaccine responders . Additionally, children with ascariasis who received albendazole prior to receiving oral cholera vaccine were 88% (p = 0.06) more likely to seroconvert than children who were not dewormed . Interactions that diminish responses to vaccines at the time of vaccination may also diminish immune recall of vaccines at the time of disease exposure. As HIV-infected children are more susceptible to vaccine preventable illness and death than other children , even after the introduction of anti-retroviral therapy , deworming HIV-infected children may have a measurable impact on vaccine preventable infections.
The World Health Organization (WHO) recommends annual or bi-annual school-based deworming as a cost-effective strategy to diminish the consequences of chronic helminth infection. Deworming could also be considered part of the nutritional care package for HIV-infected children, to reduce the consequences of malnutrition and anemia in HIV. Incorporating deworming into routine HIV care and treatment is an ideal way to improve the nutritional health of HIV-infected children, and may provide additional benefits. This may be particularly beneficial for children under 5 years of age, who represent 10%–20% of the 2 billion people infected with helminths worldwide . Annual deworming of preschool-age children is safe and highly effective in reducing parasite prevalence and intensity, malnutrition, and risk of stunting, but a formal policy does not yet exist to target this age group , . Because children are infected and often diagnosed with HIV while very young, preschool-aged children can easily be dewormed in HIV clinics, along with siblings, to reduce the occurrence of reinfection.
Despite WHO recommendations, school-based implementation is not universal and many helminth-infected school-age children go untreated. Children who are sick or otherwise unable to attend school may miss school-based interventions, leading to more illness and absenteeism. Children with HIV may also be less likely to receive other health services. For example, HIV-infected children are less likely to receive complete vaccination series compared to uninfected children . HIV care centers are an important, and highly accessed, point of serial contact for HIV-infected children and their families . However, at present they often provide a narrow range of services. In addition to integrating deworming into current HIV treatment, the integration of other necessary childhood health interventions, including vitamin supplementation, immunizations, safe drinking water (through home water filtration), and insecticide-treated bed nets, may further reduce HIV-related morbidity and mortality among these children .
Challenges may exist in coupling other health interventions to HIV care, but the potential benefits warrant consideration. Deworming both in schools and HIV clinics is likely justified by the high rates of recurrent infection in children and the low cost of the intervention. Finally, little evidence exists on the impact of deworming in HIV-infected children, highlighting a need for more rigorous studies. These studies should investigate the effects of helminth infection on responses to immunizations, the potential interactions between antihelminthics and HIV treatment, the optimal timing of deworming around both immunizations and ART initiation, and the impact of deworming on incidence of vaccine preventable infections.
The benefits of treating and preventing helminth infections in HIV-infected children may go beyond the improved nutritional status and cognitive development observed in all children to also include improved responses to immunizations and control of other infectious diseases. Enhanced control of neglected infectious diseases, such as helminth infections, through existing HIV care and treatment programs, may further reduce childhood morbidity and mortality in this vulnerable population.
- 1. UNAIDS (2008) HIV and AIDS estimates and data, 2007 and 2001. 2008 Report on the global AIDS epidemic. Geneva: UNAIDS.
- 2. Brooker S, Clements ACA, Bundy DAP (2006) Global epidemiology, ecology and control of soil-transmitted helminth infections. In: Advances in parasitology. Simon I, Hay AG, David JR, editors. Academic Press. 221–261.
- 3. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, et al. (2006) Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 367: 1521–1532.
- 4. Moreau E, Chauvin A (2010) Immunity against helminths: interactions with the host and the intercurrent infections. J Biomed Biotechnol 2010: 428593.
- 5. Blish CA, Sangare L, Herrin BR, Richardson BA, John-Stewart G, et al. (2010) Changes in plasma cytokines after treatment of ascaris lumbricoides infection in individuals with HIV-1 infection. J Infect Dis 201: 1816–1821.
- 6. Sangare LR, Herrin BR, John-Stewart G, Walson JL (2011) Species-specific treatment effects of helminth/HIV-1 co-infection: a systematic review and meta-analysis. Parasitology 138: 1546–1558.
- 7. Walson JL, Herrin BR, John-Stewart G (2009) Deworming helminth co-infected individuals for delaying HIV disease progression. Cochrane Database Syst Rev CD006419.
- 8. Walson JL, Otieno PA, Mbuchi M, Richardson BA, Lohman-Payne B, et al. (2008) Albendazole treatment of HIV-1 and helminth co-infection: a randomized, double-blind, placebo-controlled trial. AIDS 22: 1601–1609.
- 9. Walson JL, John-Stewart G (2007) Treatment of helminth co-infection in individuals with HIV-1: A systematic review of the literature. PLoS Negl Trop Dis 1: e102 doi:10.1371/journal.pntd.0000102.
- 10. Levine MM (2010) Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine. BMC Biology 8.
- 11. Walker CLF, Black RE (2011) Rotavirus vaccine and diarrhea mortality: quantifying regional variation in effect size. BMC Public Health 11.
- 12. Grassly NC, Fraser C, Wenger J, Deshpande JM, Sutter RW, et al. (2006) New strategies for the elimination of polio from India. Science 314: 1150–1153.
- 13. Labeaud AD, Malhotra I, King MJ, King CL, King CH (2009) Do antenatal parasite infections devalue childhood vaccination? PLoS Negl Trop Dis 3: e442 doi:10.1371/journal.pntd.0000442.
- 14. Elias D, Britton S, Aseffa A, Engers H, Akuffo H (2008) Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-beta production. Vaccine 26: 3897–3902.
- 15. Noland GS, Chowdhury DR, Urban JF Jr, Zavala F, Kumar N (2010) Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice. Vaccine 28: 2917–2923.
- 16. Da'dara AA, Harn DA (2010) Elimination of helminth infection restores HIV-1C vaccine-specific T cell responses independent of helminth-induced IL-10. Vaccine 28: 1310–1317.
- 17. Triki H, Abdallah MV, Ben Aissa R, Bouratbine A, Ben Ali Kacem M, et al. (1997) Influence of host related factors on the antibody response to trivalent oral polio vaccine in Tunisian infants. Vaccine 15: 1123–1129.
- 18. Cooper PJ, Chico ME, Losonsky G, Sandoval C, Espinel I, et al. (2000) Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR. J Infect Dis 182: 1199–1206.
- 19. Roca A, Sigauque B, Quinto L, Morais L, Berenguera A, et al. (2010) Estimating the vaccine-preventable burden of hospitalized pneumonia among young Mozambican children. Vaccine 28: 4851–4857.
- 20. Bekker V, Scherpbier H, Pajkrt D, Jurriaans S, Zaaijer H, et al. (2006) Persistent humoral immune defect in highly active antiretroviral therapy-treated children with HIV-1 infection: loss of specific antibodies against attenuated vaccine strains and natural viral infection. Pediatrics 118: e315–e322.
- 21. Albonico M, Allen H, Chitsulo L, Engels D, Gabrielli AF, et al. (2008) Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. PLoS Negl Trop Dis 2: e126 doi:10.1371/journal.pntd.0000126.
- 22. WHO (2003) Report of the WHO informal consultation on the use of Praziquantel during pregnancy/lactation and albendazole/mebendazole in children under 24 months. Geneva: WHO.
- 23. Ndirangu J, Barnighausen T, Tanser F, Tint K, Newell ML (2009) Levels of childhood vaccination coverage and the impact of maternal HIV status on child vaccination status in rural KwaZulu-Natal, South Africa*. Trop Med Int Health 14: 1383–1393.
- 24. De Baets AJ, Bulterys M, Abrams EJ, Kankassa C, Pazvakavambwa IE (2007) Care and treatment of HIV-infected children in Africa: issues and challenges at the district hospital level. Pediatr Infect Dis J 26: 163–173.