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Correction: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

  • Guang Xu,
  • Nicole L. Mendell,
  • Yuejin Liang,
  • Thomas R. Shelite,
  • Yenny Goez-Rivillas,
  • Lynn Soong,
  • Donald H. Bouyer,
  • David H. Walker

Correction: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection

  • Guang Xu, 
  • Nicole L. Mendell, 
  • Yuejin Liang, 
  • Thomas R. Shelite, 
  • Yenny Goez-Rivillas, 
  • Lynn Soong, 
  • Donald H. Bouyer, 
  • David H. Walker
PLOS
x

Fig 7A is incorrect. The label “CD8-/- Infected” should read “MHC I-/- Infected”. The authors have provided a corrected version here.

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Fig 7. Histopathological comparison of MHC I-/- mice and WT mice infected with O. tsutsugamushi.

Foci of inflammation (arrows), including infiltration of macrophages and lymphocytes, were observed in infected mice (A, mag: 100x, 400x inset). Many apoptotic cells, possibly neutrophils, were observed in the liver of MHC I-/- mice. Increased necrosis and steatosis (arrows with circle end) were observed in the livers of MHC I-/- mice. Higher pathology scores indicating greater injury were observed in the livers of infected mice (B). There were significantly more apoptotic cells in the liver (C) and kidney (D) of MHC I-/- mice than their WT counterparts. All infected mice had increased apoptosis compared to uninfected mice. *, p<0.05; ***, p<0.001, n = 8; each tissue sample was blindly scored by four experienced investigators.

https://doi.org/10.1371/journal.pntd.0006127.g001

Reference

  1. 1. Xu G, Mendell NL, Liang Y, Shelite TR, Goez-Rivillas Y, Soong L, et al. (2017) CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection. PLoS Negl Trop Dis11(7): e0005763. https://doi.org/10.1371/journal.pntd.0005763 pmid:28723951