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Genetic Reconstruction of Protozoan rRNA Decoding Sites Provides a Rationale for Paromomycin Activity against Leishmania and Trypanosoma

  • Sven N. Hobbie,

    Current address: Singapore-MIT Alliance for Research and Technology (SMART), Singapore, Singapore

    Affiliation Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

  • Marcel Kaiser,

    Affiliations Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

  • Sebastian Schmidt,

    Current address: Roche Diagnostics, Rotkreuz, Switzerland

    Affiliation Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

  • Dmitri Shcherbakov,

    Affiliation Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

  • Tanja Janusic,

    Affiliation Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

  • Reto Brun,

    Affiliations Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

  • Erik C. Böttger

    boettger@imm.uzh.ch

    Affiliation Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland

Genetic Reconstruction of Protozoan rRNA Decoding Sites Provides a Rationale for Paromomycin Activity against Leishmania and Trypanosoma

  • Sven N. Hobbie, 
  • Marcel Kaiser, 
  • Sebastian Schmidt, 
  • Dmitri Shcherbakov, 
  • Tanja Janusic, 
  • Reto Brun, 
  • Erik C. Böttger
PLOS
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