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A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

  • Elizabeth R. Sharlow,

    Affiliations University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  • Todd A. Lyda,

    Affiliation Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

  • Heidi C. Dodson,

    Affiliation Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

  • Gabriela Mustata,

    Affiliation Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  • Meredith T. Morris,

    Affiliation Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

  • Stephanie S. Leimgruber,

    Affiliations University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  • Kuo-Hsiung Lee,

    Affiliation Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

  • Yoshiki Kashiwada,

    Affiliation Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan

  • David Close,

    Affiliations University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  • John S. Lazo,

    Affiliations University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  • James C. Morris

    jmorri2@clemson

    Affiliation Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

  • Elizabeth R. Sharlow, 
  • Todd A. Lyda, 
  • Heidi C. Dodson, 
  • Gabriela Mustata, 
  • Meredith T. Morris, 
  • Stephanie S. Leimgruber, 
  • Kuo-Hsiung Lee, 
  • Yoshiki Kashiwada, 
  • David Close, 
  • John S. Lazo
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