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Peter U. Fischer, Christopher L. King, Julie A. Jacobson, Gary J. Weil
Potential Value of Triple Drug Therapy with Ivermectin, Diethylcarbamazine, and Albendazole (IDA) to Accelerate Elimination of Lymphatic Filariasis and Onchocerciasis in Africa
www.plosntds.org
www.plosntds.org
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[( )3()10(\n)15( )-13()4(\n)12()-4()]TJ
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(16)Tj
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(].)Tj
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-35.5575 -1.2983 Td
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1.0318 0 Td
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3.3165 0 Td
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1.4683 0 Td
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-34.8262 -1.2982 Td
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(individuals)Tj
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3.3165 0 Td
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4.5184 0 Td
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5.777 0 Td
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3.4299 0 Td
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1.559 0 Td
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1.9956 0 Td
(onchocerciasis)Tj
6.0661 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
-20.7948 -1.2983 Td
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2.4718 0 Td
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-35.2344 -1.2983 Td
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(ocular)Tj
2.7326 0 Td
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(worsen)Tj
3.118 0 Td
(preexisting)Tj
4.6262 0 Td
(onchocercal)Tj
5.0569 0 Td
(eye)Tj
1.5194 0 Td
(disease)Tj
3.016 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\))Tj
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3.4413 0 Td
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1.5534 0 Td
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1.474 0 Td
(posterior)Tj
-33.3238 -1.2982 Td
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2.3358 0 Td
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5.9243 0 Td
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1.7292 0 Td
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2.4434 0 Td
(atrophy\))Tj
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([)Tj
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(18)Tj
0 g
(,)Tj
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1.7405 0 Td
(25)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(].)Tj
3.2031 0 Td
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3.1351 0 Td
(the)Tj
1.474 0 Td
(1980s,)Tj
2.7042 0 Td
(a)Tj
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(single)Tj
-34.8092 -1.2983 Td
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1.0148 0 Td
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4.5184 0 Td
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1.7008 0 Td
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(clearing)Tj
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3.3959 0 Td
[()]TJ
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(.)Tj
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1.1395 0 Td
[( )3()10(\n)15( )-13()4(\n)12()-4()]TJ
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3.4129 0 Td
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1.7291 0 Td
(ivermectin)Tj
4.5184 0 Td
(treatment)Tj
4.1329 0 Td
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1.542 0 Td
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(adverse)Tj
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([)Tj
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(25)Tj
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(,)Tj
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1.7348 0 Td
(29)Tj
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()Tj
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(31)Tj
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(].)Tj
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-33.9531 -1.2983 Td
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3.2144 0 Td
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2.0352 0 Td
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4.1329 0 Td
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4.2463 0 Td
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1.9956 0 Td
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1.474 0 Td
(Mf)Tj
1.4003 0 Td
(density)Tj
3.1011 0 Td
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1.0318 0 Td
(the)Tj
1.474 0 Td
(skin)Tj
-34.4804 -1.2983 Td
(and)Tj
1.7291 0 Td
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1.9956 0 Td
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1.474 0 Td
(presence)Tj
3.7077 0 Td
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(Mf)Tj
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1.0374 0 Td
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1.4684 0 Td
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(\(cornea,)Tj
3.4923 0 Td
(anterior)Tj
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(chamber,)Tj
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(retina\))Tj
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([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(].)Tj
2.075 0 Td
(A)Tj
0.9071 0 Td
(review)Tj
2.8402 0 Td
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1.0148 0 Td
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-35.977 -1.3039 Td
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3.0727 0 Td
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1.7801 0 Td
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3.016 0 Td
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1.8198 0 Td
(tolerated)Tj
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-36.2605 -1.2982 Td
(individuals)Tj
4.6487 0 Td
(with)Tj
1.9956 0 Td
(low)Tj
1.6554 0 Td
(Mf)Tj
1.4003 0 Td
(densities)Tj
3.7021 0 Td
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1.0148 0 Td
(less)Tj
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2.0296 0 Td
(10)Tj
1.1679 0 Td
(Mf/mg)Tj
3.016 0 Td
(skin)Tj
1.8936 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
2.0806 0 Td
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(one)Tj
1.6951 0 Td
(study)Tj
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(showed)Tj
-34.3783 -1.2983 Td
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1.5193 0 Td
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(the)Tj
1.474 0 Td
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(immune)Tj
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(complexes)Tj
-32.9837 -1.3039 Td
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1.0318 0 Td
(serum)Tj
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(prior)Tj
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1.7291 0 Td
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(treatment)Tj
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(doses)Tj
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(and)Tj
1.7291 0 Td
(pro-)Tj
-34.8545 -1.2983 Td
(longed)Tj
2.9366 0 Td
(courses)Tj
3.1975 0 Td
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(DEC)Tj
2.1883 0 Td
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(mg)Tj
1.508 0 Td
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1.5307 0 Td
(week)Tj
2.245 0 Td
(for)Tj
1.389 0 Td
(eight)Tj
2.1996 0 Td
(weeks,)Tj
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(200)Tj
1.6497 0 Td
(mg)Tj
1.5024 0 Td
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(week)Tj
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(for)Tj
1.3833 0 Td
(four)Tj
1.9162 0 Td
(months)Tj
-33.2615 -1.2982 Td
(after)Tj
2.0352 0 Td
(an)Tj
1.2019 0 Td
(initial)Tj
2.5455 0 Td
(course)Tj
2.8346 0 Td
(of)Tj
1.0148 0 Td
(1,100)Tj
2.3471 0 Td
(mg)Tj
1.508 0 Td
(over)Tj
1.9729 0 Td
(eight)Tj
2.2054 0 Td
(days\))Tj
2.3357 0 Td
([)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(].)Tj
-18.8049 -1.2983 Td
(Results)Tj
3.0614 0 Td
(of)Tj
1.0148 0 Td
(clinical)Tj
3.0784 0 Td
(and)Tj
1.7291 0 Td
(preclinical)Tj
4.388 0 Td
(studies)Tj
2.9877 0 Td
(suggest)Tj
3.1181 0 Td
(that)Tj
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2000 Adobe Systems Incorporated. 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