4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection
Fig 5
Development of parasitemia in acutely infected mice after the 28-day course of treatment with 9 or 12.
The photon count values are displayed for each individual animal up to 81 dpi, showing progressive parasite relapse. Post-treatment evolution of parasetimea in live animals is shown in Fig 6.