Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women
Intracellular production of IFN-γ by PBMCs was analyzed by flow cytometry. Box plots of the percentages of IFN-γ-producing cells from total CD4+ (A) or CD8+ (B) T cells are shown after PBMCs were cultured in the presence of PvLP1, PvLP2 or medium alone. In C), IFN-γ-producing cells from total CD4+ or CD8+ T cells are shown after culture in the presence of ant-CD3. IFN-γ production was compared between P. vivax infected (I, N=28) and uninfected (U, N=18) pregnant women; p corresponds to Mann-Whitney test. Median (middle line in white), and 25th and 75th percentiles (lower and upper hinge, respectively) are represented in the box. Outside values are excluded.