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Extended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine Candidate

Fig 6

Representative leg muscle histopathologic lesions in A129 mice 14 days after infection with 10⁴ PFU of the 181/clone25 or CHIKV/IRES vaccine candidate strains or PBS delivered in the footpad.

Green arrows indicate cellular infiltrate and moderate myositis.

doi: https://doi.org/10.1371/journal.pntd.0004007.g006