Levels of 8-OxodG Predict Hepatobiliary Pathology in Opisthorchis viverrini Endemic Settings in Thailand
Fig 2
Levels of creatinine corrected urinary 8-oxodG are significantly elevated in O. viverrini infected individuals with advanced periductal fibrosis (APF) and O. viverrini induced intrahepatic cholangiocarcinoma (CCA).
The distributions of 8-oxodG levels in urine are shown in Panel A for all four groups and in Panel B for three groups, with the first group in Panel B being a combination of Endemic Normal (O. viverrini negative) and the APF- participants into a single hepatobiliary negative control group. The length of the boxes represents the interquartile range (IQR) or the distance between the 25th and 75th percentiles of each urinary 8-oxodG study group. The median value of each urinary 8-oxodG group are represented by the solid horizontal line in each box; the mean value of the group is depicted by the diamond character in the boxes. The bottom whisker represents the value of the lowest observation in the group. The highest observations in the group are represented by the uppermost circles above the group box; the upper whiskers represents the highest observations within 1.5x IQR. aSignificant difference exists between this group and the APF+ individuals; this result was obtained using Dunn's procedure for multiple comparisons following the Kruskal-Wallis one way analysis of variance. bSignificant difference exists between this group and the CCA individuals; this result was obtained using Dunn's procedure for multiple comparisons following the Kruskal-Wallis one way analysis of variance.