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Dengue Research Funded by the European Commission-Scientific Strategies of Three European Dengue Research Consortia

Figure 3

Structure of the work packages (WP) of the DENFREE consortium.

For the DENFREE project work package (WP) 1 (Index case community study of the epidemiology of dengue) is a central WP, which will provide data and biological samples for other WPs. This WP is a multicentric, prospective study in Cambodia and Thailand, which will characterize local DENV transmission patterns, identify subclinical infections for mosquito transmission studies (WP5 entomology), establish empirical mosquito, human density, and geo-spatial data for use in fine-scale and agent-based simulation models (WP3 climate prediction and WP4 epidemiological models), establish a biobank of biological samples from patients, household members, and mosquito vectors for further study in other WPs (WP2 diagnostics, WP6 virology, WP7 immunology, and WP8 human genetics), and test novel diagnostic and prognostic tools developed by WP2. Contributions from each WP will bring complementary help to the consortium to achieve the main aims. WP2 will develop new point-of-care diagnostic tools that can be used in the community to screen subclinical individuals in epidemic regions and to test for DENV in mosquito samples, thereby validating a new mosquito trap tool developed by WP5. WP3 and WP4, by using better surveillance data, will help determine the underlying factors, extent, and course of a DENV epidemic. Altogether, we will provide a new strategy for dengue surveillance for better control of DENV transmission.

Figure 3