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Transcriptional Profiling of the Bladder in Urogenital Schistosomiasis Reveals Pathways of Inflammatory Fibrosis and Urothelial Compromise

Figure 2

Real-time PCR corroboration of gene transcription profiles obtained by microarray analysis.

Transcription of a subset of genes analyzed by real-time PCR is depicted in the scatter plots and is displayed as fold change relative to control-injected bladders at 1, 3 and 5 weeks post-injection. Colored bars correspond to microarray data, with decreased, increased, and unchanged transcription colored green, red, and black, respectively. Increasing intensity of green and red bars indicates more extreme changes in transcription (up to >20-fold). * = p<0.05, ** = p<0.01, ***p<0.001 in comparison to control vehicle-injected bladders (or across time points if annotated with brackets). UPK3A: uroplakin 3a, CLDN8: claudin-8, COL4A5: collagen type 4 alpha 5, COL17A1: collagen type 17 alpha 1, NOS2: inducible nitric oxide synthase, UPK3B: uroplakin 3b, UPK1B: uroplakin 1b, UPK1A: uroplakin 1a, UPK2: uroplakin 2, ARG1: arginase-1.

Figure 2

doi: https://doi.org/10.1371/journal.pntd.0001912.g002