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Transcriptional Profiling of the Bladder in Urogenital Schistosomiasis Reveals Pathways of Inflammatory Fibrosis and Urothelial Compromise

Figure 1

Volcano plots of differentially transcribed genes in egg-injected bladders.

Separate plots are shown comparing microarray-derived gene transcription in egg-injected bladders relative to control vehicle-injected bladders (A, one week post-injection; B, three weeks post-injection; C, five weeks post-injection). Log fold changes are plotted on the x-axes and negative log10 p-values are plotted on the y-axes. Red and other non-dark gray, colored symbols denote statistically significant (p<0.05) changes in gene transcription. Gray symbols denote statistically insignificant (p>0.05) changes in change transcription. Legend for individual, selected genes of interest applies to all three panels. For clarity, each selected gene of interest with multiple microarray probes has been denoted using the probe featuring the greatest differential signal for that gene.

Figure 1