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Analysis of Neglected Tropical Disease Drug and Vaccine Development Pipelines to Predict Issuance of FDA Priority Review Vouchers over the Next Decade

Figure 2

Number of PRV-eligible drugs and vaccines in the pipeline by phase of clinical development.

Drugs and vaccines from the pre-clinical phase of development, through phases I, II, and III were evaluated for PRV eligibility (Figure 1). A total of 17 drugs in clinical development could earn a PRV, if approved by the FDA; two more are already approved abroad and would be eligible to earn a voucher if submitted to the FDA (six in phase I; eight in phase II; three in phase III). Forty-five vaccines are currently undergoing clinical development (16 in phase I; 24 in phase II; five in phase III); three additional vaccines are already approved abroad and would be eligible to earn a PRV if submitted to the FDA. The analysis excluded programs that are “on hold”.

Figure 2

doi: https://doi.org/10.1371/journal.pntd.0001803.g002