Enhanced Protective Efficacy of a Chimeric Form of the Schistosomiasis Vaccine Antigen Sm-TSP-2
Figure 6
Protection against parasite challenge is associated with increased IFN-γ production.
Graphs of ELISA data showing IL-4 (left axis), IL-10 (right axis) and IFN-γ (right axis) production by splenocytes taken from mice at necropsy and restimulated with either (A) schistosome soluble egg antigen (SEA) or (B) schistosome soluble adult worm antigen (SWAP). All significant differences are compared to the control MBP-vaccinated, infected group (MBP inf) by ANOVA (**P<0.01, ***P<0.001). Unless otherwise indicated, levels are not significantly different to controls.