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A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans

Figure 6

Renal histopathology showing tubulointerstitial changes.

Representative PAS-stained kidney sections obtained from hamsters 28 days after leptospiral challenge showing, A. Normal tubular epithelium (40x); B. Moderate tubular damage (40x); C. Severe tubular atrophy (40x); D. Interstitial inflammation (arrow, 40x); E. Tubular scarring with depressed renal capsule (arrow, 4x); and F. Tubular deposition of intensely PAS-positive material consistent with Tamm-Horsfall glycoprotein (arrowheads, 40x).

Figure 6