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A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans

Figure 1

Antibody response in hamsters immunized with recombinant LigA proteins or heat-killed leptospires (HKL).

Total hamster immunoglobulin responses to immunogens were measured by ELISA. Geometric mean end-point titers and standard deviations (n = 4) are shown after the first (gray), second (blue), and third (black) immunizations. In all cases, pre-immune sera were negative. Recombinant LigA proteins are represented by their domain numbers. Asterisks indicate proteins that provided 100% protection against lethal challenge.

Figure 1

doi: https://doi.org/10.1371/journal.pntd.0001422.g001