A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans
Total hamster immunoglobulin responses to immunogens were measured by ELISA. Geometric mean end-point titers and standard deviations (n = 4) are shown after the first (gray), second (blue), and third (black) immunizations. In all cases, pre-immune sera were negative. Recombinant LigA proteins are represented by their domain numbers. Asterisks indicate proteins that provided 100% protection against lethal challenge.