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A Large Repertoire of Parasite Epitopes Matched by a Large Repertoire of Host Immune Receptors in an Invertebrate Host/Parasite Model

Figure 6

Deduced amino acid sequence of BgTEP.

The complete coding sequence of BgBRATEP was obtained (GenBank: HM003907) and the deduced precursor sequence shown here. The 1446 amino acids of the precursor share the domains and motifs of the other known invertebrates TEP. Peptides, identified by LC-MS/MS, are highlighted in grey. The putative signal peptide is underlined, the putative N-glycosylation sites are indicated in bold. The thioester site is double underlined. Proline residues important for the thioester stability are boxed. • indicate the position of the aspartate residue (D1054) of the catalytic core. Cysteins belonging to the conserved cystein array shared by other TEPs are indicated by stars. ▴ indicate residues which form the protective hydrophobic/aromatic pocket of the thioester. The putative processing site for the cleavage is underlined with broken line. The Complement Component Domain is underlined and the Receptor-Binding Domain is dotted underlined.

Figure 6

doi: https://doi.org/10.1371/journal.pntd.0000813.g006