Delineation of Diverse Macrophage Activation Programs in Response to Intracellular Parasites and Cytokines
Figure 5
Comparison of transcriptional responses to cytokines implicated in classical macrophage activation.
A. Unsupervised two-dimensional cluster analysis was performed on genes exhibiting statistically significant variability between stimulation with IFNG, IFNB, TNF, and IL-17, as determined by multiclass SAM (n = 773). B. The Venn diagram depicts the overlap of genes significantly upregulated, as determined by pairwise SAM analysis to unstimulated controls, by IFNG, IFNB, TNF, both IFNG and IFNB, both IFNG and TNF, both IFNB and TNF, and all three cytokines.