Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

Anton Simeonov; Ajit Jadhav; Ahmed A. Sayed; Yuhong Wang; Michael E. Nelson; Craig J. Thomas; James Inglese; David L. Williams; Christopher P. Austin

doi:10.1371/journal.pntd.0000127

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Open Access

Peer-reviewed

Research Article

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

Anton Simeonov,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ajit Jadhav,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ahmed A. Sayed,

Affiliation Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America
⨯
Yuhong Wang,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Michael E. Nelson,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Craig J. Thomas,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
James Inglese,

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
David L. Williams ,

* E-mail: dlwilli@ilstu.edu (DLW); austinc@mail.nih.gov (CPA)

Affiliation Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America
⨯
Christopher P. Austin

* E-mail: dlwilli@ilstu.edu (DLW); austinc@mail.nih.gov (CPA)

Affiliation NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

Anton Simeonov,
Ajit Jadhav,
Ahmed A. Sayed,
Yuhong Wang,
Michael E. Nelson,
Craig J. Thomas,
James Inglese,
David L. Williams,
Christopher P. Austin

Published: January 2, 2008
https://doi.org/10.1371/journal.pntd.0000127

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Posted by jopaki on 03 Jan 2008 at 22:15 GMT

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Schistosoma mansoni
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Oxidation-reduction reactions
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Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

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Posted by jopaki on 03 Jan 2008 at 22:15 GMT