TY - JOUR T1 - Spatial Predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) Prevalence in Kaberamaido and Dokolo, Two Newly Affected Districts of Uganda A1 - Batchelor, Nicola A. A1 - Atkinson, Peter M. A1 - Gething, Peter W. A1 - Picozzi, Kim A1 - Fèvre, Eric M. A1 - Kakembo, Abbas S. L. A1 - Welburn, Susan C. Y1 - 2009/12/15 N2 -
Human African Trypanosomiasis (HAT) or sleeping sickness is a parasitic disease of humans, transmitted by the tsetse fly. There are two different forms of HAT: Rhodesian (in eastern sub-Saharan Africa), which also affects wild and domestic animals, and Gambian (in western and central sub-Saharan Africa). Diagnosis and treatment of the two diseases differ, and disease characterisation is based on prior knowledge of known geographical disease distributions. Presently, the two forms of HAT do not overlap in any area: Uganda is the only country which sustains active transmission of both types.
In recent years, Rhodesian HAT has spread into areas of Uganda that had not previously been affected, thus narrowing the gap between areas of Rhodesian and Gambian HAT transmission. This spread has raised concerns of a potential overlap of the two types of the disease, which would severely complicate their diagnosis and treatment. Earlier work indicated that Rhodesian HAT was introduced to Soroti district due to the movement of untreated cattle from affected areas. Here we show that the continued spread of HAT in Uganda (to a further 2 districts) may also have occurred due to cattle movements, despite legal requirements to treat livestock from affected areas prior to sale at markets. These findings can assist in the targeting of HAT control efforts in Uganda and show that the stringent implementation of animal treatments at livestock markets should be a priority.JF - PLoS Negl Trop Dis JA - PLoS Negl Trop Dis VL - 3 IS - 12 UR - http://dx.doi.org/10.1371%2Fjournal.pntd.0000563 SP - e563 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pntd.0000563 ER -