Antibody Signature of Spontaneous Clearance of Chlamydia trachomatis Ocular Infection and Partial Resistance against Re-challenge in a Nonhuman Primate Trachoma Model

Laszlo Kari; Lauren E. Bakios; Morgan M. Goheen; Leah N. Bess; Heather S. Watkins; Timothy R. Southern; Lihua Song; William M. Whitmire; Norma Olivares-Zavaleta; Harlan D. Caldwell

doi:10.1371/journal.pntd.0002248

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Peer-reviewed

Research Article

Antibody Signature of Spontaneous Clearance of Chlamydia trachomatis Ocular Infection and Partial Resistance against Re-challenge in a Nonhuman Primate Trachoma Model

Laszlo Kari,

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Lauren E. Bakios ,

Contributed equally to this work with: Lauren E. Bakios, Morgan M. Goheen

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Morgan M. Goheen ,

Contributed equally to this work with: Lauren E. Bakios, Morgan M. Goheen

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Leah N. Bess,

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Heather S. Watkins,

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Timothy R. Southern,

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Lihua Song,

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
William M. Whitmire,

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Norma Olivares-Zavaleta,

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Harlan D. Caldwell

* E-mail: hcaldwell@niaid.nih.gov

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯

Antibody Signature of Spontaneous Clearance of Chlamydia trachomatis Ocular Infection and Partial Resistance against Re-challenge in a Nonhuman Primate Trachoma Model

Laszlo Kari,
Lauren E. Bakios,
Morgan M. Goheen,
Leah N. Bess,
Heather S. Watkins,
Timothy R. Southern,
Lihua Song,
William M. Whitmire,
Norma Olivares-Zavaleta,
Harlan D. Caldwell

Published: May 30, 2013
https://doi.org/10.1371/journal.pntd.0002248

About the Authors

Laszlo Kari

Affiliation Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

Lauren E. Bakios

Contributed equally to this work with: Lauren E. Bakios, Morgan M. Goheen

Morgan M. Goheen

Contributed equally to this work with: Lauren E. Bakios, Morgan M. Goheen

Leah N. Bess

Heather S. Watkins

Timothy R. Southern

Lihua Song

William M. Whitmire

Norma Olivares-Zavaleta

Harlan D. Caldwell

* E-mail: hcaldwell@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HDC LK. Performed the experiments: LEB MMG LK LNB HSW TRS LS WMW NOZ. Analyzed the data: HDC LK. Wrote the paper: HDC LK.

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Chlamydia infection
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Chlamydia trachomatis
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Antibodies
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Monkeys
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Trachoma
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Antigen processing and recognition
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Antigenic variation
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Immunoprecipitation
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