About the Authors

Kenny K. H. Ang

Affiliation The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

Joseline Ratnam

Affiliation The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America

Jiri Gut

Affiliation Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

Jennifer Legac

Affiliation Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

Elizabeth Hansell

Affiliation The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

Zachary B. Mackey

Affiliation The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

Katarzyna M. Skrzypczynska

Affiliation The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

Anjan Debnath

Affiliation The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

Juan C. Engel

Affiliation The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America

Philip J. Rosenthal

Affiliation Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

James H. McKerrow

Affiliations The Sandler Center for Drug Discovery, University of California San Francisco, San Francisco, California, United States of America, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

Michelle R. Arkin

michelle.arkin@ucsf.edu (MRA); adam.renslo@ucsf.edu (ARR)

Affiliations The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Adam R. Renslo

michelle.arkin@ucsf.edu (MRA); adam.renslo@ucsf.edu (ARR)

Affiliations The Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KKHA JR JG JL EH ZBM KMS AD JCE. Performed the experiments: KKHA JR JG JL EH ZBM KMS AD JCE. Analyzed the data: KKHA JR JG JL EH ZBM KMS AD JCE PJR JHM MRA ARR. Contributed reagents/materials/analysis tools: JR JG JL EH ZBM KMS AD JCE. Wrote the paper: PJR JHM MRA ARR.