About the Authors

Chiung-Kuang Chen

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

Siegfried S. F. Leung

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

Christophe Guilbert

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

Matthew P. Jacobson

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

James H. McKerrow

Affiliation Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America

Larissa M. Podust

larissa.podust@ucsf.edu

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

Competing Interests

Matthew P. Jacobson is a consultant to Schrodinger, LLC.

Author Contributions

Conceived and designed the experiments: MPJ LMP. Performed the experiments: CKC SSFL LMP. Analyzed the data: CKC SSFL CG LMP. Contributed reagents/materials/analysis tools: CG MPJ JHM LMP. Wrote the paper: JHM LMP.